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Yunivita, Vycke
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Health Professions Medicine & Pharmacology Nursing Public Health

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POTENSI QUERCETIN-3-O-GLUCOSIDE (Q3G) DAN QUERCETIN-4-O-GLUCOSIDE (Q4G) DARI DAUN MIMBA (AZADIRACHTA INDICA A.JUSS) TERHADAP AMBILAN GLUKOSA Rohmawaty, Enny; Yunivita, Vycke
Majalah Kedokteran Bandung Vol 48, No 4 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.819 KB) | DOI: 10.15395/mkb.v48n4.913

Abstract

Daun mimba (Azadirachta indica A.Juss) yang berasal dari BPT Situbondo memiliki zat aktif quercetin-3-O-glucoside (Q3G) dan quercetin-4-O-glucoside (Q4G) yang diketahui mempunyai kemampuan menghambat ambilan glukosa melalui membran usus halus. Penelitian ini bertujuan mengetahui potensi isolat dan dosis optimal Q3G dan Q4G dari daun mimba terhadap ambilan glukosa melalui membran usus halus tikus putih (Rattus rattus novergicus). Zat aktif Q3G dan Q4G dari daun mimba diisolasi secara kualitatif dengan metode Kromatografi Lapis Tipis (KLT). Penelitian ini dilakukan di beberapa tempat, antara lain: Laboratorium Kimia Organik FMIPA Unpad, Laboratorium Biokimia FK Unpad, serta Laboratorium Farmakologi dan Terapi FK Unpad. Penelitian dilakukan pada bulan Juni?Desember 2011. Penelitian laboratorium eksperimental dengan rancangan acak lengkap dilakukan terhadap 30 ekor tikus putih yang dibagi dalam 5 kelompok. Kelompok kontrol diberi larutan glukosa 3,0 x 10-3M, dan 4 kelompok perlakuan diberi larutan glukosa berturut-turut Q3G 1 mg/kgBB, Q3G 2 mg/kgBB, Q4G 1 mg/kgBB, dan Q4G 2 mg/kgBB menggunakan alat perfusi in situ. Kadar ambilan glukosa diamati setiap 15 menit selama 1 jam. Data dianalisis menggunakan one-way ANOVA dan tes Duncan dengan taraf kepercayaan 95% (?=0,05). Hasil penelitian menunjukkan sebanyak 53,1 mg isolat Q3G dan 14,4 mg Q4G diperoleh dari daun mimba BPT Situbondo sebanyak 1 kg. Isolat Q3G 1 mg/kgBB, Q4G 1 mg/kgBB, dan Q4G 2 mg/kgBB berbeda secara bermakna dalam menghambat ambilan glukosa melalui membran usus halus tikus dibanding dengan kontrol pada menit ke-45 (p<0,05). Simpulan, isolat Q3G dan Q4G dari daun mimba dapat menghambat ambilan glukosa melalui membran usus halus tikus putih. [MKB. 2016;48(4):222?7]Kata kunci: Ambilan glukosa, daun mimba, Q3G, Q4GPotential Influence of Quercetin-3-O-Glucoside (Q3g) and Quercetin-4-O-Glucoside (Q4g) from Mimba Leaves (Azadirachta indica a.juss) on Glucose UptakeAbstractMimba leaves (Azadirachta indica A.Juss), which was obtained from Brigade Proteksi Tanaman (BPT) Situbundo in this study, contain active compounds of quercetin-3-O-glucoside (Q3G) and quercetin-4?-O-glucoside (Q4G). These compounds were isolated using the Thin Layer Chromatography (TLC). From previous studies, Q3G and Q4G are known to inhibit the glucose uptake from intestinal membrane. This study was conducted to understand the potential influence of Q3G and Q4G isolated from mimba leaves in inhibiting glucose uptake in rat?s intestinal membrane (Rattus rattus norvegicus). This experimental study employed 30 male rats that met the inclusion criteria that were divided into 5 groups (n=6). Group I was the control group and only received glucose solution 3,0 x 10-3 M. Group II, III, IV, and V received glucose solution with Q3G 1 mg/kgBW, Q3G 2 mg/kgBW, Q4G 1 mg/kgBW, and Q4G 1 2 mg/kgBW, respectively. The inhibitory potentials of Q3G and Q4G on glucose uptake was measured every 15 minutes for one hour using in situ perfusion equipment. Data were analyzed using One-way ANOVA and Duncan test with a significance level 95% (?=0.05). From 1 kg fresh mimba leaves, 60.1 mg Q3G and 14.4 mg Q4G were isolated. This study showed that Q3G 1 mg/kgBW, Q4G 1 mg/kgBW, and Q4G 2 mg/kgBW significantly inhibited glucose uptake from rat intestinal membrane compared to negative control at 45th minute (p<0.05). Therefore, Q3G and Q4G isolated from mimba leaves have significantly inhibit glucose uptake from rat?s intestinal membrane (Rattus rattus norvegicus). [MKB. 2016;48(4):222?7]Key words: Glucose uptake, mimba leaves, Q3G, Q4G
Tinjauan Literatur: PERAN HESPERIDIN DAN DIOSMIN PADA TERAPI COVID-19 BERDASARKAN STUDI IN SILICO Bukit, Raihan Shaquille; Ramadhanti, Julia; Yunivita, Vycke
Majalah Kesehatan Vol. 10 No. 3 (2023): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2023.010.03.7

Abstract

Corona Virus Disease-19 (COVID-19) yang disebabkan oleh Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) menyebar dengan cepat di seluruh dunia. Para peneliti berupaya untuk menemukan terapi untuk penyakit ini. Strategi penemuan terapi ini salah satunya dengan menggunakan obat di luar indikasi asalnya (drug repurposing) yang lebih cepat diperoleh dan terjangkau dibandingkan penemuan obat baru. Hasil skrining terhadap obat yang sudah tersedia dan senyawa alami, menunjukkan hesperidin dan diosmin memiliki potensi untuk menginhibisi siklus hidup SARS-CoV-2. Hesperidin dan Diosmin dalam bentuk Micronized Purified Flavonoid Fraction (MPFF), sebelumnya digunakan sebagai pengobatan insufisiensi vena kronik. Tujuan penulisan kajian ini yaitu untuk mengkaji potensi hesperidin dan diosmin dalam menginhibisi jalur infeksi COVID-19. Metode yang digunakan pada kajian pustaka ini yaitu metode tinjauan pustaka naratif dengan pencarian literatur melalui database Google Scholar, Pubmed, dan ScienceDirect. Hasil kajian yang dilakukan menunjukkan dari 2012 jurnal didapatkan 16 jurnal in silico yang menunjukkan target pengobatan pada infeksi COVID-19 pada hesperidin dan diosmin diantaranya dapat menghambat reseptor Angiotensin Converting Enzyme 2 (ACE2) yang menjadi tempat SARS-CoV-2 berikatan dengan sel inang, menghambat aktivitas Transmembrane Serine Protease 2 (TMPRSS2), menghambat proses proteolitik dengan menghambat enzim 3Clpro, menghambat aktivitas RNA dependent RNA polymerase (RdRp) yang menghambat pembentukan protein struktural SARS-CoV-2. Selain itu, hesperidin dapat menghambat aktivitas protein virus nucleocapsid dan menghambat sitokin pro-inflammatory. Sebagai kesimpulan, hesperidin dan diosmin dapat menjadi kandidat yang potensial dalam menginhibisi COVID-19.
Rationality of Empirical Antibiotic Usage among Digestive Surgery Inpatients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia: Gyssens Criteria Analysis Yunivita, Vycke; Assyifa, Nanda; Yarman, Indra Prasetya; Bashari, Muhammad Hasan; Satriasih, Tulus
Althea Medical Journal Vol 11, No 3 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n3.3299

Abstract

Background: Many empirical antibiotics are prescribed unnecessarily, contributing to the rise in the incidence of antibiotic resistance. Preventing infection of surgical sites is one of the most frequent purposes of empirical antibiotic usage. Therefore, this study aimed to analyze the rationality of empirical antibiotic usage among digestive surgery inpatients based on the Gyssens criteria and clinical features outcomes.Methods: A descriptive method was used with a cross-sectional design. Data was collected from medical records of patients underwent digestive surgery and had received empirical antibiotic therapy post-surgery from July to September 2021 at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Subsequently, the data was analyzed using the Gyssens method to qualitatively assess the rationality of antibiotic use based on specific criteria, classified from rational (category 0) to various levels of irrational use (categories I-VI). Clinical outcomes were evaluated by assessing leukocyte count, clinical symptoms of fever, and the appearance of surgical site infection before and after administration of empirical antibiotics.Results: In total, 70 empirical antibiotic prescriptions were obtained from 42 patients, with only 40% of patients using rational antibiotics, whereas 60% of antibiotics were used inappropriately (category I-VI). Clinical evaluation showed no fever, edema, or erythema and reduced leukocytosis and exudate/pus post-therapy.Conclusions: Inappropriate empirical antibiotic prescription for digestive surgery inpatients at Dr. Hasan Sadikin General Hospital based on the Gyssens criteria is high. Nonetheless, clinical outcomes showed improvements in infection-related parameters. These results emphasize the importance of stricter adherence to antibiotic stewardship and regular evaluation of empirical antibiotic practices to optimize usage and patient outcomes.
Antifungal Drug Resistance Profile in Candida sp. as a Cause of Oral Candidiasis: A Scoping Review Anastasia, Mutiara; Mauli Warma Dewi, Intan; Yunivita, Vycke
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.7

Abstract

Candida sp. is renowned for causing oral candidiasis. The prevalence of this disease is around 20-25% and the prevalence can increase in patients with systemic factors (40.2,%). Meanwhile, resistance to antifungal drugs can worsen the prognosis, especially in patients who have systemic risk factors. Therefore, this study aimed to analyze the resistance profile of Candida sp. as a cause of oral candidiasis. The scoping review method was used based on Preferred Reporting Items for Systematic Reviews and Meta-Analyse Extensions for Scoping Reviews. Data were collected through the Pubmed, Springer Open, and Google Scholar databases. Based on the inclusion and exclusion criteria, a total of 18 articles were analyzed. The results showed that antifungal drug resistance test profile depended on the species of Candida and the status of comorbid disease. Based on species, antifungal drug resistance was higher in non-Candida albicans than in Candida albicans. In the comorbid group, Candida sp. resistance to antifungal drugs was higher in the azole group. Meanwhile, in the group without comorbidities, antifungal drug resistance in groups with comorbidities is higher in flucytosine, econazole, and ketoconazole groups than in nystatin, caspofungin, and miconazole. This suggest that the use of nystatin is still effective for treating oral candidiasis. Healthcare provider may need consider prescribing nystatin, especially for patients with systemic risk factors.
Hubungan Tingkat Pengetahuan dan Sikap Civitas Akademika terhadap Penanganan Demam Wicaksono, Nauval Wahyu; Sumaedi, Tyarannisa Putri; Saiful Bahri, Nursyazana Najwa Binti; Ariz, Muhammad Hadyan; Hadisoewono, Amabel; Fauziah, Syifa; Dominic, Andreyan Symond; Jihan, Adila; Tanoto, Jeremy; Yunivita, Vycke
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 10 (2025): Volume 8 No 10 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i10.22453

Abstract

ABSTRAK Demam merupakan gejala awal penting dari infeksi tropis di Indonesia. Indonesia sebagai negara tropis memiliki beban penyakit infeksi yang tinggi, terutama yang ditularkan melalui vektor maupun droplet, seperti demam tifoid, demam berdarah dengue (DBD), malaria, dan common cold (nasofaringitis). Keempat penyakit ini sering kali memiliki gejala awal yang serupa, yaitu demam, namun pemahaman masyarakat mengenai penanganannya masih terbatas.Tujuan dari kegiatan ini adalah untuk melihat hubungan tingkat pengetahuan dengan sifat civitas akademika terhadap penanganan demam dan pemberian edukasi kepada civitas akademika. Intervensi edukatif yang tepat sasaran, terutama menyasar kelompok potensial seperti civitas akademika yang memiliki kapasitas sebagai agen perubahan. Penelitian ini menggunakan desain cross-sectional kuantitatif untuk menganalisis hubungan antara pengetahuan dengan sikap penanganan demam pada 101 civitas akademika salah satu perguruan tinggi di Jawa Barat. Data dikumpulkan melalui kuesioner dan dianalisis dengan uji Chi-Square Pearson. Hasil: Hasil menunjukkan 39,6% responden memiliki pengetahuan tinggi dan 63,4% menunjukkan sikap baik. Terdapat hubungan signifikan antara pengetahuan dan sikap (p = 0,002), di mana separuh responden berpengetahuan tinggi bersikap baik, sementara 48,6% dari kelompok berpengetahuan rendah menunjukkan sikap kurang baik. Responden dengan pengetahuan tinggi lebih sering mengukur suhu secara berkala (40,6%), sedangkan kelompok berpengetahuan rendah cenderung memberi antipiretik berdasarkan perasaan subjektif (34,5%). Parasetamol menjadi antipiretik utama yang digunakan oleh responden (45,5%). Temuan ini menegaskan pentingnya edukasi berbasis bukti untuk meningkatkan literasi kesehatan dan praktik penanganan demam, khususnya di kalangan akademisi sebagai agen perubahan komunitas. Kata Kunci: Demam, Pengetahuan, Sikap, Civitas akademika, Jawa Barat     ABSTRACT Fever is an important initial symptom of tropical infections in Indonesia. Indonesia as a tropical country has a high burden of infectious diseases, especially those transmitted through vectors and droplets, such as typhoid fever, dengue fever (DBD), malaria, and common cold (nasopharyngitis). These four diseases often have similar initial symptoms, namely fever, yet public understanding of its management remains limited.  The purpose of this activity is to examine the relationship between knowledge levels and academic characteristics regarding fever management and the provision of education to academics. Targeted educational interventions, particularly targeting potential groups such as academics who have the capacity to act as agents of change, are essential. This study employed a quantitative cross-sectional design to analyze the relationship between knowledge and fever management attitudes among 101 members of the academic community at a university in West Java. Data was collected via questionnaire and analyzed using Pearson's Chi-Square test. Results showed that 39.6% of respondents have high knowledge and 63.4% demonstrated good attitudes. A significant relationship was found between knowledge and attitude (p = 0.002), with half of the high-knowledge respondents exhibiting good attitudes, while 48.6% of the low-knowledge group showed less favorable attitudes. Respondents with high knowledge more frequently measured temperature periodically (40.6%), whereas the low-knowledge group tended to administer antipyretics based on subjective feelings (34.5%). Paracetamol was the primary antipyretic used (45.5%). These findings confirm the importance of evidence-based education to improve health literacy and fever management practices, particularly among academics as community change agents. Keywords: Fever, knowledge, Attitude, Academic community, West Java
Penyuluhan Skabies pada Mahasiswa Penghuni Asrama di Salah Satu Perguruan Tinggi Sumedang Yunivita, Vycke; Ranadhia, Simran; Zahrah, Najla Rafifah; Putri, Reida Salsabila; Adynda, Diandra Aulia; Yasjudan, Amalia Utami; Situmeang, Fania Wardah Rahaf; Yahya, Puti Cut Nurzahrina; Khansa, Alya Naura; Wibisono, Nauval Wahyu
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 7 (2025): Volume 8 No 7 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i7.20452

Abstract

ABSTRAK Skabies merupakan penyakit kulit menular yang disebabkan oleh infestasi tungau Sarcoptes scabiei, yang banyak ditemukan di lingkungan padat seperti asrama. Rendahnya pengetahuan terhadap gejala awal dan cara pencegahan penyakit ini berpotensi mempercepat penularan di komunitas. Program SAHARA (Scabies Away, Healthy Ramadan) dilaksanakan di Asrama 1, Sumedang, untuk mengetahui indikasi kasus skabies, pengetahuan penghuni asrama dan efektivitas penyuluhan sebagai metode untuk meningkatkan pengetahuan penghuni asrama. Sebanyak 34 responden ikut dalam pre-assessment, dan 30 responden mengikuti program SAHARA termasuk pre-test dan post-test. Metode penyuluhan mencakup presentasi materi, diskusi, dan permainan edukatif. Hasil skrining menunjukkan bahwa tidak ada responden yang terindikasi kasus skabies. Rata-rata nilai pre-test meningkat dari 58.67 menjadi 91.67 pada post-test, dengan nilai N-Gain sebesar 0.798 yang termasuk dalam kategori efektivitas tinggi. Dapat disimpulkan bahwa penyuluhan dalam Program SAHARA efektif dalam meningkatkan pengetahuan responden mengenai skabies di lingkungan asrama. Metode penyuluhan dapat diaplikasikan untuk kegiatan promotif dan preventif terkait penyakit kulit di lingkungan kampus. Kata Kunci: Skabies, Asrama Mahasiswa, Penyuluhan, N-Gain  ABSTRACT Scabies is a contagious skin disease caused by an infestation of the mite Sarcoptes scabiei, which is commonly found in densely populated environments such as dormitories. Low awareness of early symptoms and prevention methods can accelerate transmission within communities. The SAHARA Program (Scabies Away, Healthy Ramadan) was conducted at Dormitory 1 in Sumedang to identify potential scabies cases, assess residents’ knowledge, and evaluate the effectiveness of educational outreach in increasing awareness among dormitory residents. A total of 34 respondents participated in the pre-assessment, and 30 respondents took part in the full SAHARA Program, including both pre-test and post-test phases. The educational methods included material presentations, discussions, and interactive learning games. Screening results indicated that no respondents were identified with scabies. The average pre-test score increased from 58.67 to 91.67 in the post-test, with an N-Gain score of 0.798, which falls into the high-effectiveness category. It was concluded that the educational outreach within the SAHARA Program was effective in enhancing respondents’ knowledge about scabies in the dormitory environment. This outreach method could be applied to promotive and preventive health efforts related to skin diseases within campus settings. Keywords: Scabies, Student Dormitory, Outreach, N-Gain
Co-Authors Adynda, Diandra Aulia Anastasia, Mutiara Ariz, Muhammad Hadyan Assyifa, Nanda Bashari, Muhammad Hasan Bukit, Raihan Shaquille Dominic, Andreyan Symond Enny Rohmawaty Hadisoewono, Amabel Jihan, Adila Khansa, Alya Naura Mauli Warma Dewi, Intan Putri, Reida Salsabila Ramadhanti, Julia Ranadhia, Simran Saiful Bahri, Nursyazana Najwa Binti Satriasih, Tulus Situmeang, Fania Wardah Rahaf Sumaedi, Tyarannisa Putri Syifa Fauziah Tanoto, Jeremy Wibisono, Nauval Wahyu Wicaksono, Nauval Wahyu Yahya, Puti Cut Nurzahrina Yarman, Indra Prasetya Yasjudan, Amalia Utami Zahrah, Najla Rafifah