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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research PROFESSIONAL HEALTH JOURNAL Bioscientia Medicina : Journal of Biomedicine and Translational Research
Rizki, Fitri Amelia
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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Does Long-Term Oxygen Therapy Reduce Exacerbations in Chronic Obstructive Pulmonary Disease? A Meta-Analysis Rizki, Fitri Amelia; Yessy Susanty Sabri; Afriani, Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1150

Abstract

Background: Chronic obstructive pulmonary disease (COPD) exacerbations contribute significantly to morbidity, mortality, and healthcare costs. While long-term oxygen therapy (LTOT) is a standard treatment for severe resting hypoxemia in COPD, its impact on exacerbations remains unclear. This meta-analysis aimed to evaluate the effect of LTOT on the frequency and severity of COPD exacerbations. Methods: A systematic search of PubMed, Embase, and Cochrane Library was conducted (January 2018 to December 2023) for randomized controlled trials (RCTs) comparing LTOT to no LTOT in COPD patients. The primary outcome was the rate of moderate to severe COPD exacerbations. Secondary outcomes included hospitalization due to exacerbations and all-cause mortality. The risk of bias was assessed using the Cochrane Risk of Bias tool. A random-effects model was used to pool data, and heterogeneity was assessed using the I² statistic. Results: Nine RCTs with 2,949 participants were included. LTOT was associated with a statistically significant reduction in the rate of moderate to severe exacerbations (Rate Ratio [RR] 0.72; 95% Confidence Interval [CI] 0.67 to 0.78; p < 0.000001), representing an estimated 28% reduction. LTOT also significantly reduced hospitalization for exacerbations (RR 0.69; 95% CI 0.61 to 0.79; p < 0.000001) and all-cause mortality (RR 0.71; 95% CI 0.57 to 0.89; p = 0.003). Conclusion: LTOT significantly reduces the frequency of moderate to severe COPD exacerbations, related hospitalizations, and all-cause mortality. These findings support LTOT use in eligible COPD patients to improve clinical outcomes.
Diagnosis And Management Of Pulmonary Tuberculosis In Hiv With Severe Immunodeficiency Rizki, Fitri Amelia; Medison, Irvan; Anggrainy, Fenty
PROFESSIONAL HEALTH JOURNAL Vol. 7 No. 1 (2025): In Progress issue
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v7i1.1016

Abstract

The total number of TB cases in Indonesia is 969,000. This figure represents a 17% increase compared to 2020. SITB 2022 data shows there are 15,375 cases of co-infection of pulmonary TB with HIV. The treatment success rate for pulmonary TB co-infection with HIV in Indonesia in 2022 is 71%. This is still far from the national target of 90%.This case report discusses a 33-year-old man with pulmonary TB and TB lymphadenitis with HIV at clinical stage 4. The CD4 count was 10 cells/mm3. The degree of immunodeficiency suffered by this patient is severe immunodeficiency. The management was to administer OAT first, followed by ART within 2 weeks after OAT was administered and well tolerated. OAT was administered for 9 months due to the presence of TB lymphadenitis. Treatment evaluation showed clinical improvement and the patient did not develop IRIS. The incidence of IRIS in patients with TB is 8%-43%. Factors influencing the occurrence of IRIS include the CD4 count at the start of ART.
Diagnosis And Management Of Pulmonary Tuberculosis In Hiv With Severe Immunodeficiency Rizki, Fitri Amelia; Medison, Irvan; Anggrainy, Fenty
PROFESSIONAL HEALTH JOURNAL Vol. 7 No. 1 (2025): December
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v7i1.1016

Abstract

The total number of TB cases in Indonesia is 969,000. This figure represents a 17% increase compared to 2020. SITB 2022 data shows there are 15,375 cases of co-infection of pulmonary TB with HIV. The treatment success rate for pulmonary TB co-infection with HIV in Indonesia in 2022 is 71%. This is still far from the national target of 90%.This case report discusses a 33-year-old man with pulmonary TB and TB lymphadenitis with HIV at clinical stage 4. The CD4 count was 10 cells/mm3. The degree of immunodeficiency suffered by this patient is severe immunodeficiency. The management was to administer OAT first, followed by ART within 2 weeks after OAT was administered and well tolerated. OAT was administered for 9 months due to the presence of TB lymphadenitis. Treatment evaluation showed clinical improvement and the patient did not develop IRIS. The incidence of IRIS in patients with TB is 8%-43%. Factors influencing the occurrence of IRIS include the CD4 count at the start of ART.
Does Long-Term Oxygen Therapy Reduce Exacerbations in Chronic Obstructive Pulmonary Disease? A Meta-Analysis Rizki, Fitri Amelia; Yessy Susanty Sabri; Afriani, Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1150

Abstract

Background: Chronic obstructive pulmonary disease (COPD) exacerbations contribute significantly to morbidity, mortality, and healthcare costs. While long-term oxygen therapy (LTOT) is a standard treatment for severe resting hypoxemia in COPD, its impact on exacerbations remains unclear. This meta-analysis aimed to evaluate the effect of LTOT on the frequency and severity of COPD exacerbations. Methods: A systematic search of PubMed, Embase, and Cochrane Library was conducted (January 2018 to December 2023) for randomized controlled trials (RCTs) comparing LTOT to no LTOT in COPD patients. The primary outcome was the rate of moderate to severe COPD exacerbations. Secondary outcomes included hospitalization due to exacerbations and all-cause mortality. The risk of bias was assessed using the Cochrane Risk of Bias tool. A random-effects model was used to pool data, and heterogeneity was assessed using the I² statistic. Results: Nine RCTs with 2,949 participants were included. LTOT was associated with a statistically significant reduction in the rate of moderate to severe exacerbations (Rate Ratio [RR] 0.72; 95% Confidence Interval [CI] 0.67 to 0.78; p < 0.000001), representing an estimated 28% reduction. LTOT also significantly reduced hospitalization for exacerbations (RR 0.69; 95% CI 0.61 to 0.79; p < 0.000001) and all-cause mortality (RR 0.71; 95% CI 0.57 to 0.89; p = 0.003). Conclusion: LTOT significantly reduces the frequency of moderate to severe COPD exacerbations, related hospitalizations, and all-cause mortality. These findings support LTOT use in eligible COPD patients to improve clinical outcomes.
Co-Authors Afriani Afriani Anggrainy, Fenty Irvan Medison Yessy Susanty Sabri