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All Journal Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan
Kharisma Jayak P
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Humanities Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Veterinary Other

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Analisis Efektivitas Biaya Penggunaan Obat Antihipertensi pada Pasien Rawat Inap BPJS RSUD Prambanan Yogyakarta Tahun 2022 Nurul Istiqomah; Kusumaningtyas S.A; Kharisma Jayak P
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.430

Abstract

Hypertension is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg in two measurements with an interval of five minutes in a state of sufficient rest/calm. The aim of this study was to determine and compare the cost-effectiveness of antihypertensive drug combination therapy in BPJS inpatient hypertension patients at Prambanan Regional Hospital, Yogyakarta. This research was conducted non-experimentally using a descriptive research design of retrospective health phenomena based on a hospital perspective. The data used is secondary data (in the form of medical record data, financial data) and the research design used is cross-sectional. Inclusion criteria are hypertensive patients ≥18 years old with a primary diagnosis of stage II hypertension with or without comorbidities with BPJS payment. Cost effectiveness was carried out using the ACER and ICER methods. The results of the study showed that the most effective combination of antihypertensives was a combination of ACEI with diuretics. The direct medical costs for the combination of CCB and ACEI are IDR 1,229,906. The use of a combination of ACEI with diuretics is the most cost-effective with an ACER value of IDR. 14,313 and an ICER value of IDR. 10,070.
Hubungan Determinan dengan Kualitas Hidup dan Outcome Terapi pada Pasien Gagal Ginjal Kronis Dengan Hemodialisis di RS Pku Muhammadiyah Surakarta: Penelitian Pradina Arifah Nurcahyani; Kharisma Jayak P; Anna Fitriawati
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 3 No. 4 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 3 Nomor 4 (April 2025
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v3i4.876

Abstract

The purpose of this study was to determine the quality of life and outcome of therapy for Chronic Kidney Failure patients undergoing hemodialysis at PKU Muhammadiyah Surakarta Hospital, the frequency distribution of each factor, and to analyze the relationship between each factor and the patient's quality of life. This research method is a correlation with a cross-sectional approach involving 71 respondents of CKD patients undergoing hemodialysis. This study used primary data using the WHOQOL questionnaire and laboratory data. The results of the study were that most respondents had a good quality of life 52%, 70% of respondents were male, 59% were elderly, 51% had completed their last education at high school/vocational high school, and 63% were working. The results of the Spearman Rank test showed no significant relationship between the determinants, namely between age and gender factors with patient quality of life, and between therapy outcomes with patient quality of life, but there was a relationship between education and employment factors with the quality of life of Chronic Kidney Failure patients.
Uji Aktivitas Antidiabetes dari Ekstrak Daun Salam (Syzygium polyanthum) Menggunakan Metode Inhibisi Enzim α-Amilase Secara In Vitro Devi Nur Indah Sari; Kharisma Jayak P; Tatiana Siska Wardani
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i3.6852

Abstract

Diabetes Mellitus is a metabolic disorder caused by the pancreas failing to produce insulin hormone adequately. Based on the cause, diabetes mellitus is classified into three types, including type 1 DM, type 2 Diabetes Mellitus, and gestational diabetes mellitus. Hyperglycemia can also occur due to food consumed that is not balanced with physical activity carried out so that fat accumulates in the body and causes blood to be unable to enter the body's cells, ultimately increasing blood sugar levels. Signs and symptoms that often appear in Diabetes Mellitus patients are polydipsia (excessive thirst), polyuria (frequent urination due to excessive urine production), polyphagia (quickly feeling hungry even though you eat a lot and want to eat continuously) and weight loss without a clear cause. Symptoms of diabetes mellitus can be controlled by increasing physical activity, following a healthy diet, and getting enough rest. Several studies have proven that bay leaves have the potential as an antidiabetic. This study aims to determine the content of secondary metabolic compounds and the antidiabetic activity of bay leaf extract using α-amylase enzyme inhibition in vitro. This research method uses laboratory experiments. This study uses α-amylase enzyme inhibition to determine the antidiabetic activity contained in bay leaf extract. The method used is DNSA. The results of this study obtained a yield of bay leaf extract of 30%, water content of simplicia of 6.24%, drying loss of simplicia of 5.3%, ash content test of 5.6%, water content test of extract of 6.34%, drying loss test of extract of 7.03%. Bay leaf extract positively contains secondary metabolite compounds, namely saponins, tannins, flavonoids, and alkaloids. The results of IC50 in bay leaf extract of 66.705 ppm are classified as strong antidiabetic. The results of acarbose of 56.818 ppm are classified as strong antidiabetic.
Co-Authors Anna Fitriawati Devi Nur Indah Sari Kusumaningtyas S.A NURUL ISTIQOMAH Pradina Arifah Nurcahyani Wardani, Tatiana Siska