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All Journal The Indonesian Biomedical Journal Indonesian Journal of Global Health research Jurnal EduHealth Mandala of Health : A Scientific Journal Medical and Health Journal Journal of General Procedural Dermatology and Venereology Indonesia
Ismiralda Oke Putranti
Department Of Dermato-venereology, Faculty Of Medicine, Jendral Soedirman University
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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HLA-Cw6 Allele Expression is Associated with Good Narrowband Ultraviolet B Response in Javanese-Indonesian Psoriasis Subjects Thianti Sylviningrum; Ismiralda Oke Putranti; Octavia Permata Sari; Fitranto Arjadi; Triasari Oktavriana
The Indonesian Biomedical Journal Vol 13, No 3 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i3.1494

Abstract

BACKGROUND: Psoriasis is an autoimmune disease involving genetic-environmental factors. Human Leukocyte Antigen (HLA)-Cw6 allele is the main genetic risk factor of psoriasis, but its prevalence varies widely. HLA-Cw6 allele correlates with psoriasis clinical type and treatment responses. Narrowband ultraviolet B (NB-UVB) and methotrexate (MTX) are effective psoriasis treatments but their association with HLA-Cw6 allele has not been identified. The study aims to determine the association between HLA-Cw6 allele expression, NB-UVB, and MTX treatment responses in Javanese-Indonesian psoriasis subjects.METHODS: Ninety Javanese-Indonesian psoriasis subjects were recruited in this study, 45 subjects were treated using NB UVB, while the other 45 subjects were treated using MTX, respectively, for 12 weeks. The psoriasis diagnosis and treatment responses were evaluated by dermatologists using Psoriasis Area Severity Index (PASI) score. The HLA-Cw6 allele was examined using the single-specific-primer polymerase chain reaction method. Fisher's Exact and Chi-square tests were employed, where p-value<0.05 was considered of significant association.RESULTS: The HLA-Cw6 allele positivity was identified in 23 psoriasis subjects (25.56%), while the other 67 subjects expressed HLA-Cw6 allele negative (74.44%). Female with HLA-Cw6 allele positivity who did not have comorbid disease show good response to NB-UVB than MTX. Meanwhile, subjects who were treated with MTX showed no association between therapeutic response and HLA-Cw6. HLA-Cw6 status was not correlated with the onset of psoriasis, family history, and comorbid diseases in all subjects.CONCLUSION: HLA-Cw6 allele expression is more associated with good NB-UVB treatment response than with MTX treatment response in female Javanese-Indonesian psoriasis subjects without comorbid disease.KEYWORDS: HLA-Cw6, narrowband ultraviolet B, methotrexate, Javanese, psoriasis 
PERBEDAAN PREVALENSI PENYAKIT INFEKSI MENULAR SEKSUAL DI INSTALASI RAWAT JALAN RSUD Prof. dr. MARGONO SOEKARJO PERIODE 2010 – 2014 Ismiralda Oke Putranti; Citra Primanita; Lilik Karsono; Amelia B. Rahardjo
Mandala Of Health Vol 11 No 1 (2018): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (467.392 KB) | DOI: 10.20884/1.mandala.2018.11.1.541

Abstract

Infeksi menular seksual (IMS) saat ini menjadi masalah yang cukup besar selain karena jumlah kasus baru yang masih tinggi, juga karena IMS dapat menimbulkan gejala yang berat, infertilitas dan disabilitas baik pada laki-laki, perempuan maupun bayi. Penelitian ini bertujuan untuk mengetahui perbedaan prevalensi dan karakteristik IMS berdasarkan jenis kelamin di Instalasi Rawat Jalan (IRJ) RSUD Prof dr. Margono Soekarjo pada kurun waktu 2010 – 2014. Penelitian ini merupakan penelitian observasional analitik menggunakan data sekunder rekam medis elektronik. Hasil penelitian didapatkan jumlah kasus IMS di RSUD Prof dr. Margono Soekarjo cukup tinggi, yaitu sebanyak 511 kasus selama kurun waktu 5 tahun penelitian. Pada kasus laki-laki sebanyak 54,9% dan perempuan sebanyak 45,1% dengan puncak kejadian pada usia 20 – 30 tahun. Uretritis gonore merupakan penyakit IMS terbanyak pada laki-laki (76,8%), sedangkan kondiloma akuminata terbanyak pada perempuan (62,2%) dan tidak ada perbedaan yang signifikan diantara kedua kelompok jenis kelamin (p=0,64; p>0,05). Uretritis gonore dan kondiloma akuminata merupakan penyakit IMS terbanyak pada laki-laki dan perempuan pada penelitian ini, serta tidak adanya perbedaan yang bermakna prevalensi IMS di antara kedua kelompok sesuai dengan penelitian-penelitian sebelumnya yang menyatakan bahwa laki-laki dan perempuan memiliki kerentanan yang sama dalam terpapar IMS. Dari penelitian ini tidak ada perbedaan yang bermakna prevalensi IMS pada pasien laki-laki maupun perempuan di IRJ RSUD Prof dr. Margono Soekarjo.
PERBEDAAN TINGKAT KEPARAHAN PSORIASIS PADA PASIEN PSORIASIS DENGAN DAN TANPA FOKAL INFEKSI Caroline Astrid; Ismiralda Oke Putranti; Kurniasih Dwi Purwanti
Mandala Of Health Vol 11 No 2 (2018): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (367.958 KB) | DOI: 10.20884/1.mandala.2018.11.2.944

Abstract

Psoriasis adalah penyakit kulit yang sering dijumpai, kronik, tidak menular, terjadi akibat kelainan kompleks pada pertumbuhan dan diferensiasi epidermal serta abnormalitas multipel dari biokimia, imunologi, dan vaskular. Salah satu faktor risiko psoriasis adalah fokal infeksi. Penelitian ini bertujuan mengetahui perbedaan tingkat keparahan psoriasis pada pasien psoriasis dengan dan tanpa disertai fokal infeksi di RSUD Prof. Dr. Margono Soekarjo, Purwokerto. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross-sectional. Subjek penelitian adalah 40 pasien psoriasis yang berobat di Poli Kulit dan Kelamin RSUD Prof. Dr. Margono Soekarjo pada bulan November hingga Desember 2017 yang memenuhi kriteria inklusi dan eksklusi. Tingkat keparahan psoriasis diukur menggunakan Psoriasis Area Severity Index (PASI). Analisis data menggunakan independent t-test. Rata-rata tingkat keparahan psoriasis pada pasien dengan fokal infeksi 28,63 dan tanpa fokal infeksi 17,29, dengan jenis fokal infeksi didapatkan fokal infeksi intraoral (47,5%) dan genital (2,5%). Perbedaan tingkat keparahan psoriasis pada pasien dengan dan tanpa fokal infeksi didapatkan p = 0,000 (p < 0,05). Terdapat perbedaan signifikan tingkat keparahan psoriasis pada pasien dengan dan tanpa fokal infeksi. Psoriasis is a common, chronic, noncontagious skin disease, caused by complex abnormal epidermal growth with multiple abnormality of biochemistry, immunology, and vascular. One of psoriasis risk factors is focal infection. This study was an analytical study with cross-sectional approach, to establish the difference of Psoriasis Area Severity Index (PASI) in patients with and without focal infections in Prof. Dr. Margono Soekarjo Public Hospital, Purwokerto. Subjects of this study were psoriasis outpatients in Dermatology and Venereology Clinic in November until December 2017. Forty subjects who fulfilled the inclusion and exclusion criteria were measured using PASI. This study showed the average of the PASI on patients with focal infections was 28.63 and without focal infections was 17.29, with types of the focal infection were intraoral focal infections (47,5%) and genital focal infections (2,5%). The difference of PASI between patients with and without focal infections was significant with p = 0,000 (p < 0,05). There is a significant difference on degree of psoriasis between patients with and without focal infections.
TINJAUAN PUSTAKA: FOTOBIOLOGI ULTRAVIOLET PADA JARINGAN KULIT Ismiralda Oke Putranti; Yulia Sistina
Mandala Of Health Vol 16 No 1 (2023): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2023.16.1.8379

Abstract

Kulit merupakan organ terluas dari tubuh kita yang berfungsi terutama sebagai protector. Salah satu fungsi proteksi kulit adalah melindungi tubuh kita terhadap paparan sinar UV yang dari berbagai penelitian menyebabkan banyak kerusakan pada kulit, mukosa maupun memberikan dampak buruk bagi organ tubuh lainnya. Pemahaman mengenai dampak sinar UV pada kulit dijelaskan dalam fotobiologi yang terus berkembang hingga sekarang. Tinjauan pustaka ini membahas mengenai biologi kulit dan perubahannya pada paparan sinar UV.
PENGARUH EKSTRAK DAUN COCOR BEBEK (Bryophyllum pinnatum) TERHADAP PERTUMBUHAN Escherichia coli WILD-TYPE DAN ATCC 35218 Nia Krisniawati; Nurul Fadiah; Ismiralda Oke Putranti
Mandala Of Health Vol 16 No 1 (2023): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2023.16.1.8388

Abstract

Indonesia merupakan negara yang memiliki banyak keanekaragaman hayati dan hewani yang bermanfaat sebagai obat tradisonal yang dapat menjadi pengobatan alternatif. Salah satu tumbuhan yang dapat digunakan adalah bagian daun dari tumbuhan Cocor Bebek yang memiliki manfaat seperti antibakteri, anti diabetes, anti oksidan, dan sebagainya serta mengandung senyawa aktif seperti flavonoid, alkaloid, saponin dan steroid. Escherichia coli adalah flora normal yang bersifat patogen dalam tubuh. Pemberian ekstrak daun Cocor Bebek yang bersifat antibakteri diperkirakan memiliki efek yang dapat menghambat pertumbuhan bakteri Escherichia coli wild-type dan ATCC 35218. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak daun Cocor Bebek dalam menghambat pertumbuhan bakteri Escherichia coli wild-type dan ATCC 35218. Penelitian ini merupakan penelitian eksperimental nyata dengan rancangan Post-Test-Only Control Group Design. Daun Cocor Bebek diekstraksi dengan metanol menggunakan metode maserasi. Sampel penelitian terdiri dari biakan murni Escherichia coli wild-type dan ATCC 35218 dengan kepadatan 1,5 X 108 sel/ ml. Pengujian dengan metode Difusi Cakram Kirby Bauer dengan konsentrasi ekstrak 20%, 40%, 60%, 80%, aquades sebagai kontrol negatif dan amoxicillin-clavulanat sebagai kontrol positif. Hasil penelitian menunjukkan ekstrak daun Cocor Bebek tidak dapat menghambat pertumbuhan bakteri Escherichia coli ATCC 35218 dan Escherichia coli wild-type karena kemungkinan kedua bakteri termasuk dalam bakteri ESBL. Pada penelitian sebelumnya mengatakan bahwa 66,7% komunitas yang ada di Purwokerto merupakan carrier tanpa gejala. Kesimpulan penelitian ini, ekstrak daun Cocor Bebek tidak memiliki efek penghambatan dalam pertumbuhan bakteri Escherichia coli wild-type dan ATCC 35218.
LAPORAN KASUS: TRANSFORMASI ERITRODERMA PSORIATIKA MENJADI LIMFOMA SEL T-KUTAN Ismiralda Oke Putranti; Amelia B Rahardjo; Citra Primanita; Lilik Karsono; Arundito Widikusumo
Medical and Health Journal Vol 2 No 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (604.252 KB) | DOI: 10.20884/1.mhj.2023.2.2.8377

Abstract

Background: Erythrodermic psoriasis (EP) is a severe type of psoriasis, a chronic inflammatory disease characterized by general erythematous condition with thick scale all around the body. The treatment of EP consists systemic medications like cyclosporine or methotrexate and biologic agents, which lately suggested related to the development of cutaneous T-cell lymphoma (CTCL) in severe psoriasis patients. Case Report: A 45-year old, Javanese male was diagnosed previously with EP that transformed to CTCL. His previous history, he was histologically confirmed as psoriasis vulgaris since 2014 and was treated regularly with methotrexate. After 5 years, he gradually suffered several episodes of erythrodermic condition and was diagnosed with erythrodermic psoriasis with unusual pruritic hyperkeratotic plaques and ulcers on his trunks without any general lymph nodes enlargement. Peripheral blood smear showed Sezary cell and histopathology result confirmed CTCL. He was treated with combination of radiotherapy, phototherapy and topical regiments with a good result and acceptable. Discussion: Several studies suggested that severe psoriasis had increased the susceptibility of CTCL, especially with the use of cyclosporine, methotrexate or biologic agents as the treatment. In this case, methotrexate might play role in the development of CTCL or enhanced the transformation of EP to CTCL. Combination of localized radiation therapy, NBUVB and topical therapy gave a quiet good result for the skin condition and increased patient’s quality of life. Conclusion: Erythrodermic psoriasis might transform or develop to CTCL which in this case was probably related to the use of methotrexate.
Severe kerion celsi effectively treated with skin debridement and antifungals Putranti, Ismiralda Oke; Primanita, Citra
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 2, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Kerion celsi is a severe inflamed deep abscesses form of tinea capitis which mostly occurs in children population. Despite good regular treatment with antifungals, the prognosis of kerion celsi is poor with scarring alopecia. Case Illustration: A 5-year-old boy had history of an alopecia with locally large painful oedema on his scalp a month before treatment. From the physical examination, a painful large area with alopecia was found with abscess covered by thick crust. Pull test showed hair breakage and right retro-auricular lymphatic nodes enlargement was also found. Endo-ectothrix spores were positive in potassium-hydroxide examination and the culture showed colony of Trichophyton mentagrophytes. A surgical debridement was performed to remove the thick crust covering the abscess with alopecia and followed by application of normal saline gauze dressing and terbinafine cream on the top of the lesion for 6 weeks. Systemic micronized griseofulvin was also administered for 6 weeks. Combination treatment of debridement-topical and systemic antifungal gave a good result without scarring alopecia. Discussion: Kerion celsi was diagnosed based on clinical findings and mycological examination. From the laboratory examination, a dermatophyte fungal infection was found. Skin debridement was performed to create a good environment for topical antifungal application and wound healing, with 20mg/kg bodyweight of systemic griseofulvin administered as the first line therapy for tinea capitis. A good prognosis was achieved after those treatments combination. Conclusion: In this case, combination between skin debridement with topical and systemic antifungals gave a better result in treating kerion celsi.
HERPES ZOSTER DENGAN MANIFESTASI KLINIS MENYERUPAI ILEUS PARALITIK: LAPORAN KASUS Sylviningrum, Thianti; Putranti, Ismiralda Oke; Ardianto, Ferdi Wiweko
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.9424

Abstract

Latar Belakang: Herpes zoster (HZ) adalah penyakit erupsi vesikuler yang mengenai kulit dan saraf tepi akibat reaktivasi dari Varicella Zoster Virus (VZV). Reaktivasi VZV dapat menyebabkan neuropati dan lesi kulit vesikular yang terdistribusi sesuai dengan dermatom saraf. Neuropati pada sistem saraf enterik yang jarang dijumpai dapat berupa pseudo-obstruksi intestinal dengan gambaran klinis Ileus paralitik. Kami melaporkan kasus HZ dengan gambaran klinis menyerupai Ileus paralitik yang apabila terlambat ditangani akan meningkatkan morbiditas dan mortalitas penderitanya. Presentasi Kasus: Seorang laki-laki berusia 59 tahun datang ke Instalasi Gawat Darurat Rumah Sakit dengan keluhan perut teraba keras, dinding tegang, nyeri, tidak bisa kentut dan defekasi diikuti plenting isi air dari perut sampai punggung kanan. Hasil pemeriksaan fisik menunjukkan penurunan bising usus, dan erupsi lesi vesikuler dengan dasar kulit eritem terdistribusi dermatomal T8-10 dekstra. Pemeriksaan darah menunjukkan peningkatan monosit dan gula darah sewaktu, sedangkan hasil pemeriksaan radiologi abdomen tampak pelebaran usus besar dan distribusi udara normal di kolon. Hasil tes Tzanck dijumpai sel datia berinti banyak. Penderita didiagnosis HZ dan menunjukkan perbaikan setelah diberi asiklovir dan gabapentin. Simpulan: Neuropati pada sistem saraf enterik karena VZV perlu dipertimbangkan pada gambaran klinis Ileus paralitik disertai lesi kulit vesikuler yang patognomonik untuk HZ
Gender Differences in Scabies Risk Factors at Darul ‘Ulum Islamic Boarding School, Cilacap Aulia, Fadhila Shufi; Putranti, Ismiralda Oke; Susiawan, Lieza Dwianasari
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.14920

Abstract

Background: The global prevalence of scabies remains high, with approximately 300 million cases reported annually. Despite educational and behavioral interventions implemented in Islamic boarding schools, case reduction has been insignificant. Gender-related risk factors for scabies require further investigation. Objective: This study aimed to determine the differences in scabies risk factors between males and females at A.P.I Darul ‘Ulum Islamic Boarding School, Cilacap. Methods: An observational analytic study with a cross-sectional approach was conducted on 37 students selected through total sampling from February to March 2024. Data were collected using questionnaires and physical examinations and analyzed using Fisher's exact test. Results: Scabies was identified in 10.8% of the respondents (4 out of 37), all of whom were males. Most respondents exhibited poor personal hygiene (73.0%) and normal nutritional status (56.8%). Significant differences were found in scabies incidence based on gender (p=0.036), knowledge level (p<0.001), and nutritional status (p=0.003). However, personal hygiene did not show a significant correlation with scabies incidence (p=0.557). Male respondents with underweight nutritional status and low knowledge levels had a higher risk of scabies (40%). Conclusion: There were differences in scabies risk factors between males and females at A.P.I Darul ‘Ulum Islamic Boarding School, Cilacap.
The The Effect of Tobacco Cigarette and Electronic Cigarette Exposure on Body Microbiota: A Systematic Review in Animal Models Permatasari, Nopsa Azzahra Dwi; Putranti, Ismiralda Oke
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6404

Abstract

Exposure to tobacco and e-cigarette (vape) smoke is a significant factor affecting health, especially regarding the composition and balance of the body's microbiota. Objective to evaluate the impact of exposure to both types of cigarette smoke on body microbiota, particularly oral, gut and respiratory microbiota. A literature search was conducted following PRISMA guidelines through the Google Scholar, PubMed, and Research Gate databases for the period 2015-2025. A total of 4,257 articles were identified, and after screening, obtained 7 in vivo experimental studies using the PICO method, focusing on the effects of chronic cigarette smoke exposure on microbiota composition, inflammation, and dysbiosis were selected, all conducted on animal models. The analysis showed that exposure to tobacco and e-cigarette smoke caused microbiota dysbiosis, characterized by decreased diversity of commensal microbes and increased prevalence of pathogenic bacteria, such as Porphyromonas gingivalis in the oral microbiota, Proteobacteria in the gut microbiota, and Streptococcus, Fusobacterium, Prevotella, and Haemophilus in the respiratory tract microbiota. The main mechanisms of microbiota disruption involve oxidative stress and chronic inflammation induced by chemical components in cigarette smoke. Exposure to cigarette smoke, both tobacco and e-cigarette, has a significant impact on the body's microbiota, potentially increasing the risk of inflammatory diseases, metabolic disorders, and respiratory tract infections.
Co-Authors Amelia B Rahardjo Amelia B. Rahardjo Ardianto, Ferdi Wiweko Arundito Widikusumo Aulia, Fadhila Shufi Caroline Astrid Citra Primanita Citra Primanita Citra Primanita Fitranto Arjadi Kurniasih Dwi Purwanti Lilik Karsono Lilik Karsono Nia Krisniawati Nurul Fadiah Octavia Permata Sari Permatasari, Nopsa Azzahra Dwi Primanita, Citra Safitri, Lutfi Aulia Suryani, Luluk Kharisma Susiawan, Lieza Dwianasari Thianti Sylviningrum Triasari Oktavriana Yulia Sistina