Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

1.037

P-Index

This Author published in this journals

All Journal The Indonesian Biomedical Journal Molekul: Jurnal Ilmiah Kimia OISAA Journal of Indonesia Emas Medical and Health Journal

Thianti Sylviningrum

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Jenderal Soedirman, Jl. Dr. Gumbreg No.1, Purwokerto 53112

Author-ID : 3209120

Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

Published : 6 Documents Claim Missing Document

Claim Missing Document

Articles

PENGARUH PEMBERIAN EKSTRAK CIPLUKAN (Physalis angulata L.) TERHADAP JUMLAH FIBROBLAS PADA IMIQUIMOD-IN DUCED PSORIASIS MICE MODEL Irse Priyaganda Bani Musa; Thianti Sylviningrum; Dody Novrial; Muhamad Salman
Jurnal PPI Dunia Vol 5 No 1 (2022)
Publisher : OISAA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52162/jie.2022.005.01.7

Imiquimod menginduksi terjadinya aktivasi sel Th17 dan sel dendritik yang berperan dalam terjadinya psoriasis. Ekstrak ciplukan ( Physalis angulata L.) mengandung senyawa steroid, flavonoid, alkaloid, dan saponin seperti Physalin B, Physalin F, Physalin G yang memiliki aktivitas antiinflamasi dalam patofisiologi psoriasis. Penelitian ini merupakan penelitian eksperimental dengan post test only with control group design. Tiga puluh lima ekor mencit betina dibagi dalam 7 kelompok. Kelompok A: kontrol negatif, kelompok B: kontrol positif, kelompok C yang diinduksi imiquimod dan diberikan ekstrak ciplukan 400 mg/kgBB selama 7 hari, kelompok D yang diinduksi imiquimod dan diberikan ekstrak ciplukan 800 mg/kgBB selama 7 hari , kelompok E yang diinduksi imiquimod dan diberikan ekstrak ciplukan 1.200 mg/kgBB selama 7 hari, kelompok F yang diinduksi imiquimod dan diberikan methotreksat 1 mg/kgBB selama 7 hari, dan kelompok G yang diinduksi imiquimod dan diberikan kombinasi ekstrak ciplukan 1.200 mg/kgBB dan methotreksat 1mg/kgBB selama 7 hari. Jumlah sel fibroblas dihitung pada hari ke lima belas dengan mengambil sampel kulit mencit dan dilakukan pembuatan preparat histologi kemudian dihitung secara manual menggunakan mikroskop. Rerata jumlah sel fibroblas pada kelompok A,B,C,D,E,F,dan G masing- masing adalah 21,6±2,3; 39,2±5,5; 30,6±1,3; 24,0±2,8; 24,8± 2,9; 28,4±3,0;28,2±3,2. Hasil uji One Way ANOVA menunjukkan nilai p=0,000(p<0,05) sehzingga menunjukkan hasil signifikan.

HLA-Cw6 Allele Expression is Associated with Good Narrowband Ultraviolet B Response in Javanese-Indonesian Psoriasis Subjects Thianti Sylviningrum; Ismiralda Oke Putranti; Octavia Permata Sari; Fitranto Arjadi; Triasari Oktavriana
The Indonesian Biomedical Journal Vol 13, No 3 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i3.1494

BACKGROUND: Psoriasis is an autoimmune disease involving genetic-environmental factors. Human Leukocyte Antigen (HLA)-Cw6 allele is the main genetic risk factor of psoriasis, but its prevalence varies widely. HLA-Cw6 allele correlates with psoriasis clinical type and treatment responses. Narrowband ultraviolet B (NB-UVB) and methotrexate (MTX) are effective psoriasis treatments but their association with HLA-Cw6 allele has not been identified. The study aims to determine the association between HLA-Cw6 allele expression, NB-UVB, and MTX treatment responses in Javanese-Indonesian psoriasis subjects.METHODS: Ninety Javanese-Indonesian psoriasis subjects were recruited in this study, 45 subjects were treated using NB UVB, while the other 45 subjects were treated using MTX, respectively, for 12 weeks. The psoriasis diagnosis and treatment responses were evaluated by dermatologists using Psoriasis Area Severity Index (PASI) score. The HLA-Cw6 allele was examined using the single-specific-primer polymerase chain reaction method. Fisher's Exact and Chi-square tests were employed, where p-value<0.05 was considered of significant association.RESULTS: The HLA-Cw6 allele positivity was identified in 23 psoriasis subjects (25.56%), while the other 67 subjects expressed HLA-Cw6 allele negative (74.44%). Female with HLA-Cw6 allele positivity who did not have comorbid disease show good response to NB-UVB than MTX. Meanwhile, subjects who were treated with MTX showed no association between therapeutic response and HLA-Cw6. HLA-Cw6 status was not correlated with the onset of psoriasis, family history, and comorbid diseases in all subjects.CONCLUSION: HLA-Cw6 allele expression is more associated with good NB-UVB treatment response than with MTX treatment response in female Javanese-Indonesian psoriasis subjects without comorbid disease.KEYWORDS: HLA-Cw6, narrowband ultraviolet B, methotrexate, Javanese, psoriasis

Sub-chronic hepatotoxicity test of Plantago mayor L. extract Eman Sutrisna; Setia Wati; Farissa Utami; Rahayu Nurmalia Fauziah; Dara AisyahRahayu Abdurrachman; Ika Murti Harini; Thianti Silviningrum
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

The aim of this study was to examine hepatotoxicity of Plantago mayor L. extract on rat by using effective dosage. By experimental study and post test only with control group design. 15 rats (Rattus norvegicus) were divided in to 3 group. Group A as a natural control was given aquades. Group B and C were given extract of Plantago major L. 50mg, and 100mg/200g BW rat/day per oral. Liver function was determined with measurement of Aspartate aminotransferase (AST) level, Alanine aminotransferase (ALT), total bilirubin, and histopathological feature of liver. Blood sampling and Liver organ were taken after 28 days of intervention. The average of AST levels, ALT and total bilirubin among groups A, B and C were AST levels (145.40±52.92, 129.00±34.89, and 115.60±13.24 U/l), ALT (76.40±18.87, 83.20±18.71, and 61.00±8.45 U/l) and total bilirubin (0.56±0.03, 0.77±0.22, and 0.58±0.08 mg/dL). Statistical analysis showed that there were not significantly differences of AST levels (p=0,63; CI95%), ALT (p=0,47; CI95%) and total bilirubin (p=0,0,09; CI95%) between the groups. In histopathological features, the average Scheuer score between groups A, B and C is 1.79 ± 0.74, 3.30 ± 0.66 and 2.84 ± 0.77. There is a significant difference in Scheuer scores between the groups (p=0,005; CI95%) that show that there is a difference in the effect of giving extract of Plantago major L. to hepatocyte cells leading to a piecemeal necrosis. This study can be concluded that in effective dosage, Plantago major L. extract able to induce hepatocytes injury although it cannot cause liver disfunction yet.

THE EFFECT OF USING THE VISITING PATIENT APPLICATION ON THE STRESS LEVEL OF INPATIENTS AT MARGONO SOEKARJO HOSPITAL Hasnah Mutfii; Wahyudin Wahyudin; Lily Kusumawati Burkon; Yudhi Wibowo; Thianti Sylviningrum
Medical and Health Journal Vol 2 No 1 (2022): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Latar belakang: Stres adalah perasaan psikologis akibat adanya tekanan mental dan dapat memberi respon negatif terhadap kesehatan. Stres dapat berkurang dengan adanya penambahan pengetahuan melalui suatu informasi dan edukasi yang disampaikan dari media aplikasi. Aplikasi visiting patient adalah aplikasi berbasis android berisi tentang keutamaan orang yang sedang sakit. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan aplikasi visiting patient terhadap tingkat stres pasien rawat inap RS Margono Soekarjo. Metode: Penelitian ini menggunakan jenis kuantitatif quasi experimental dengan rancangan penelitian pre and post-test with control group design. Teknik pengambilan data secara non random sampling dengan pendekatan consecutive sampling. Jumlah responden 24 kontrol dan 24 intervensi. Pengukuran tingkat stres menggunakan kuesioner Depression and Anxiety Stress Scale (DASS) 21. Hasil: Rerata tingkat stres pre-test pada kelompok kontrol 9.67 dan pada kelompok intervensi 11.92, sedangkan rerata post-test pada kelompok kontrol 10.67 dan pada kelompok intervensi 10.25. Hasil uji Dependent T-Test kelompok intervensi didapatkan p=0.069 (p>0.05) yang berarti tidak ada perbedaan yang bermakna pada kelompok intervensi, sedangkan kelompok kontrol didapatkan p=0.037 (p<0.05) yang berarti ada perbedaan yang bermakna pada kelompok kontrol. Hasil uji Independent T-Test didapatkan p=0.796 (p>0.05) yang berarti tidak ada perbedaan yang bermakna pada kelompok intervensi dan kontrol. Kesimpulan: Penggunaan aplikasi visiting patient tidak mempengaruhi tingkat stres pasien rawat inap di RS Margono Soekarjo, tetapi hanya menambah pengetahuan pasien yang setidaknya mampu merubah sikap dan pola pikir.

HERPES ZOSTER DENGAN MANIFESTASI KLINIS MENYERUPAI ILEUS PARALITIK: LAPORAN KASUS Sylviningrum, Thianti; Putranti, Ismiralda Oke; Ardianto, Ferdi Wiweko
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.9424

Latar Belakang: Herpes zoster (HZ) adalah penyakit erupsi vesikuler yang mengenai kulit dan saraf tepi akibat reaktivasi dari Varicella Zoster Virus (VZV). Reaktivasi VZV dapat menyebabkan neuropati dan lesi kulit vesikular yang terdistribusi sesuai dengan dermatom saraf. Neuropati pada sistem saraf enterik yang jarang dijumpai dapat berupa pseudo-obstruksi intestinal dengan gambaran klinis Ileus paralitik. Kami melaporkan kasus HZ dengan gambaran klinis menyerupai Ileus paralitik yang apabila terlambat ditangani akan meningkatkan morbiditas dan mortalitas penderitanya. Presentasi Kasus: Seorang laki-laki berusia 59 tahun datang ke Instalasi Gawat Darurat Rumah Sakit dengan keluhan perut teraba keras, dinding tegang, nyeri, tidak bisa kentut dan defekasi diikuti plenting isi air dari perut sampai punggung kanan. Hasil pemeriksaan fisik menunjukkan penurunan bising usus, dan erupsi lesi vesikuler dengan dasar kulit eritem terdistribusi dermatomal T8-10 dekstra. Pemeriksaan darah menunjukkan peningkatan monosit dan gula darah sewaktu, sedangkan hasil pemeriksaan radiologi abdomen tampak pelebaran usus besar dan distribusi udara normal di kolon. Hasil tes Tzanck dijumpai sel datia berinti banyak. Penderita didiagnosis HZ dan menunjukkan perbaikan setelah diberi asiklovir dan gabapentin. Simpulan: Neuropati pada sistem saraf enterik karena VZV perlu dipertimbangkan pada gambaran klinis Ileus paralitik disertai lesi kulit vesikuler yang patognomonik untuk HZ

POTENSI PELARUT ETIL ASETAT PADA EKSTRAKSI FLAVANOID DARI TANAMAN CIPLUKAN (Physalis angulata L.) Sylviningrum, Thianti; Rianto, Bayu Dwi; Agamonanza, Freddy; Ardinas, Shinta Prima
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11407

The ciplukan plant (Physalis flavonoi L.) is widely used as a traditional medicine because it contains various bioactive compounds such as flavonoids and physalin. The purpose of this study was to identify and measure the total flavonoid content of ciplukan extracts in various solvents. Ciplukan was extracted by maceration using ethanol, n-hexane and ethyl acetate solvents. Flavonoids were identified by UV-Vis spectrophotometry at 510 nm wavelength. Total flavonoid content was measured based on the calibration curve of quercetin as the standard of comparison. The highest yield of ciplukan extract was obtained from ethanol solvent (18.5%), followed by n-hexane and ethyl acetate. The highest absorbance and total flavonoid content were found in the ethyl acetate extract, which were 0.1162 and 3,709.01 μg/g. Flavonoids from Ciplukan extract were identified most optimally in the semipolar solvent ethyl acetate compared to the polar solvent ethanol and nonpolar n-hexanes. The conclusion of this study is that ethyl acetate extract has the potential to be developed as an herbal medicinal material.

Co-Authors Agamonanza, Freddy Ardianto, Ferdi Wiweko Ardinas, Shinta Prima Dara AisyahRahayu Abdurrachman Dody Novrial, Dody Eman Sutrisna Farissa Utami Fitranto Arjadi Hasnah Mutfii Ika Murti Harini Irse Priyaganda Bani Musa Ismiralda Oke Putranti Lily Kusumawati Burkon Muhamad Salman Octavia Permata Sari Rahayu Nurmalia Fauziah Rianto, Bayu Dwi Setia Wati Triasari Oktavriana Wahyudin Wahyudin Yudhi Wibowo

Title

Found 6 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 6 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 6 Documents
Search