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All Journal The Indonesian Biomedical Journal Molekul: Jurnal Ilmiah Kimia INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY OISAA Journal of Indonesia Emas Mandala of Health : A Scientific Journal Medical and Health Journal Linggamas: Jurnal Pengabdian Masyarakat
Thianti Sylviningrum
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Jenderal Soedirman, Jl. Dr. Gumbreg No.1, Purwokerto 53112
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Engineering Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGARUH PEMBERIAN EKSTRAK CIPLUKAN (Physalis angulata L.) TERHADAP JUMLAH FIBROBLAS PADA IMIQUIMOD-IN DUCED PSORIASIS MICE MODEL Irse Priyaganda Bani Musa; Thianti Sylviningrum; Dody Novrial; Muhamad Salman
Jurnal PPI Dunia Vol 5 No 1 (2022)
Publisher : OISAA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52162/jie.2022.005.01.7

Abstract

Imiquimod menginduksi terjadinya aktivasi sel Th17 dan sel dendritik yang berperan dalam terjadinya psoriasis. Ekstrak ciplukan ( Physalis angulata L.) mengandung senyawa steroid, flavonoid, alkaloid, dan saponin seperti Physalin B, Physalin F, Physalin G yang memiliki aktivitas antiinflamasi dalam patofisiologi psoriasis. Penelitian ini merupakan penelitian eksperimental dengan post test only with control group design. Tiga puluh lima ekor mencit betina dibagi dalam 7 kelompok. Kelompok A: kontrol negatif, kelompok B: kontrol positif, kelompok C yang diinduksi imiquimod dan diberikan ekstrak ciplukan 400 mg/kgBB selama 7 hari, kelompok D yang diinduksi imiquimod dan diberikan ekstrak ciplukan 800 mg/kgBB selama 7 hari , kelompok E yang diinduksi imiquimod dan diberikan ekstrak ciplukan 1.200 mg/kgBB selama 7 hari, kelompok F yang diinduksi imiquimod dan diberikan methotreksat 1 mg/kgBB selama 7 hari, dan kelompok G yang diinduksi imiquimod dan diberikan kombinasi ekstrak ciplukan 1.200 mg/kgBB dan methotreksat 1mg/kgBB selama 7 hari. Jumlah sel fibroblas dihitung pada hari ke lima belas dengan mengambil sampel kulit mencit dan dilakukan pembuatan preparat histologi kemudian dihitung secara manual menggunakan mikroskop. Rerata jumlah sel fibroblas pada kelompok A,B,C,D,E,F,dan G masing- masing adalah 21,6±2,3; 39,2±5,5; 30,6±1,3; 24,0±2,8; 24,8± 2,9; 28,4±3,0;28,2±3,2. Hasil uji One Way ANOVA menunjukkan nilai p=0,000(p<0,05) sehzingga menunjukkan hasil signifikan.
HLA-Cw6 Allele Expression is Associated with Good Narrowband Ultraviolet B Response in Javanese-Indonesian Psoriasis Subjects Thianti Sylviningrum; Ismiralda Oke Putranti; Octavia Permata Sari; Fitranto Arjadi; Triasari Oktavriana
The Indonesian Biomedical Journal Vol 13, No 3 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i3.1494

Abstract

BACKGROUND: Psoriasis is an autoimmune disease involving genetic-environmental factors. Human Leukocyte Antigen (HLA)-Cw6 allele is the main genetic risk factor of psoriasis, but its prevalence varies widely. HLA-Cw6 allele correlates with psoriasis clinical type and treatment responses. Narrowband ultraviolet B (NB-UVB) and methotrexate (MTX) are effective psoriasis treatments but their association with HLA-Cw6 allele has not been identified. The study aims to determine the association between HLA-Cw6 allele expression, NB-UVB, and MTX treatment responses in Javanese-Indonesian psoriasis subjects.METHODS: Ninety Javanese-Indonesian psoriasis subjects were recruited in this study, 45 subjects were treated using NB UVB, while the other 45 subjects were treated using MTX, respectively, for 12 weeks. The psoriasis diagnosis and treatment responses were evaluated by dermatologists using Psoriasis Area Severity Index (PASI) score. The HLA-Cw6 allele was examined using the single-specific-primer polymerase chain reaction method. Fisher's Exact and Chi-square tests were employed, where p-value<0.05 was considered of significant association.RESULTS: The HLA-Cw6 allele positivity was identified in 23 psoriasis subjects (25.56%), while the other 67 subjects expressed HLA-Cw6 allele negative (74.44%). Female with HLA-Cw6 allele positivity who did not have comorbid disease show good response to NB-UVB than MTX. Meanwhile, subjects who were treated with MTX showed no association between therapeutic response and HLA-Cw6. HLA-Cw6 status was not correlated with the onset of psoriasis, family history, and comorbid diseases in all subjects.CONCLUSION: HLA-Cw6 allele expression is more associated with good NB-UVB treatment response than with MTX treatment response in female Javanese-Indonesian psoriasis subjects without comorbid disease.KEYWORDS: HLA-Cw6, narrowband ultraviolet B, methotrexate, Javanese, psoriasis 
Sub-chronic hepatotoxicity test of Plantago mayor L. extract Eman Sutrisna; Setia Wati; Farissa Utami; Rahayu Nurmalia Fauziah; Dara AisyahRahayu Abdurrachman; Ika Murti Harini; Thianti Silviningrum
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (349.476 KB) | DOI: 10.20884/1.jm.2019.14.1.528

Abstract

The aim of this study was to examine hepatotoxicity of Plantago mayor L. extract on rat by using effective dosage. By experimental study and post test only with control group design. 15 rats (Rattus norvegicus) were divided in to 3 group. Group A as a natural control was given aquades. Group B and C were given extract of Plantago major L. 50mg, and 100mg/200g BW rat/day per oral. Liver function was determined with measurement of Aspartate aminotransferase (AST) level, Alanine aminotransferase (ALT), total bilirubin, and histopathological feature of liver. Blood sampling and Liver organ were taken after 28 days of intervention. The average of AST levels, ALT and total bilirubin among groups A, B and C were AST levels (145.40±52.92, 129.00±34.89, and 115.60±13.24 U/l), ALT (76.40±18.87, 83.20±18.71, and 61.00±8.45 U/l) and total bilirubin (0.56±0.03, 0.77±0.22, and 0.58±0.08 mg/dL). Statistical analysis showed that there were not significantly differences of AST levels (p=0,63; CI95%), ALT (p=0,47; CI95%) and total bilirubin (p=0,0,09; CI95%) between the groups. In histopathological features, the average Scheuer score between groups A, B and C is 1.79 ± 0.74, 3.30 ± 0.66 and 2.84 ± 0.77. There is a significant difference in Scheuer scores between the groups (p=0,005; CI95%) that show that there is a difference in the effect of giving extract of Plantago major L. to hepatocyte cells leading to a piecemeal necrosis. This study can be concluded that in effective dosage, Plantago major L. extract able to induce hepatocytes injury although it cannot cause liver disfunction yet. 
THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) TO THE NUMBER OF FIBROBLASTS IN IMIQUIMOD INDUCES PSORIASIS MICE MODEL Irse Priyaganda Bani Musa; Thianti Sylviningrum; Dody Novrial; Muhamad Salman Fareza
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (441.126 KB) | DOI: 10.20884/1.mandala.2021.14.1.4763

Abstract

Imiquimod induces activation of Th17 cells and dendritic cells that play a role in psoriasis. Ciplukan extract ( Physalis angulata L.) contains steroid compounds, flavonoids, alkaloids, and saponins such as Physalin B, Physalin F, Physalin G which have anti-inflammatory activity in psoriasis pathophysiology. This research is an experimental research with post test only with control group design. Thirty five female mice were divided into 7 groups. Group A: negative control, group B: positive control, group C induced by imiquimod and given with ciplukan extract 400 mg/kg BW for 7 days, group D induced by imiquimod and given with ciplukan extract 800 mg/kg BW for 7 days, group E induced imiquimod and given with ciplukan extract 1,200 mg/kg BW for 7 days, group F induced by imiquimod and given with methotrexate 1 mg/kg BW for 7 days, and group G induced by imiquimod and given with a combination of ciplukan extract 1,200 mg/kgBW and methotrexate 1mg/kgBW for 7 days. 7 days. The number of fibroblast cells was counted on the fifteenth day by taken a sample of mouse skin and made histological preparations and then counted manually used a microscope. The mean number of fibroblast cells in groups A, B, C, D, E, F, and G were 21.6±2.3, respectively; 39.2±5.5; 30.6±1.3; 24.0±2.8; 24.8±2.9; 28,4±3,0;28,2±3,2 . The results of the test One Way ANOVA showed a value of p = 0.000 (p < 0.05), so that the results are significant. Keywords: ciplukan extract, fibroblast, methotrexate , Physalis angulata
THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) AS ANTIPSORIATIC AND TO LYMPHOCYTES COUNT OF SKIN TISSUE IN PSORIASIS MICE MODEL Putri Nur'afni Sa'adah; Thianti Sylviningrum; Dody Novrial; Fajar Wahyu Pribadi; Wahyu Dwi Kusdaryanto; Muhamad Salman Fareza
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (538.872 KB) | DOI: 10.20884/1.mandala.2021.14.1.4958

Abstract

ABSTRACT Psoriasis is a chronic skin disease in form of papule-shaped lesion and erythematous plaques with thick white scales. The pathogenesis of psoriasis involves IL-23/Th-17 cytokine pathway that contributes the activation of T-lymphocytes and proinflammatory cytokines. Treatment of psoriasis using methotrexate has inhibitory effect of the synthesis of nucleic acid towards T-lymphocytes and keratinocytes. Ciplukan (Physalis angulata L.) has anti-inflammatory potential effect which contains steroid, flavonoid, alkaloid, and physalin that may inhibit lymphocyte activation and proinflammatory cytokine production. The study is used the method of experimental study with post test only with control group design. Thirty five female mices were divided into 7 groups. The parameters of this study is anti-psoriatic (PASI and Baker’s score) and lymphocytes count in psoriasis mice model. The results of Kruskal-Wallis, PASI and Baker’s score showed that p=0,001 (p<0,05) and the result of lymphocytes count using One Way ANOVA showed that p=0,001 (p<0,05). The 800 mg/kgBW dose of ciplukan extract showed the largest decrease on PASI score and lymphocytes count, and the 1200 mg/kgBW dose one showed the largest decrease on the Baker’s score. The present of the 800 mg/kgBW dose of ciplukan extract gives the most optimal effect in reducing PASI score and skin tissue lymphocytes count in psoriasis mice model that were not significantly different with the treatment control group, while 1200 mg/kgBW dose one gives the most optimal effect in reducing Baker’s score that were significantly different with the treatment control group. Keywords: Ciplukan extract, lymphocytes, methotrexate, Physalis angulata L
THE EFFECT OF USING THE VISITING PATIENT APPLICATION ON THE STRESS LEVEL OF INPATIENTS AT MARGONO SOEKARJO HOSPITAL Hasnah Mutfii; Wahyudin Wahyudin; Lily Kusumawati Burkon; Yudhi Wibowo; Thianti Sylviningrum
Medical and Health Journal Vol 2 No 1 (2022): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (415.181 KB) | DOI: 10.20884/1.mhj.2022.2.1.8020

Abstract

Latar belakang: Stres adalah perasaan psikologis akibat adanya tekanan mental dan dapat memberi respon negatif terhadap kesehatan. Stres dapat berkurang dengan adanya penambahan pengetahuan melalui suatu informasi dan edukasi yang disampaikan dari media aplikasi. Aplikasi visiting patient adalah aplikasi berbasis android berisi tentang keutamaan orang yang sedang sakit. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan aplikasi visiting patient terhadap tingkat stres pasien rawat inap RS Margono Soekarjo. Metode: Penelitian ini menggunakan jenis kuantitatif quasi experimental dengan rancangan penelitian pre and post-test with control group design. Teknik pengambilan data secara non random sampling dengan pendekatan consecutive sampling. Jumlah responden 24 kontrol dan 24 intervensi. Pengukuran tingkat stres menggunakan kuesioner Depression and Anxiety Stress Scale (DASS) 21. Hasil: Rerata tingkat stres pre-test pada kelompok kontrol 9.67 dan pada kelompok intervensi 11.92, sedangkan rerata post-test pada kelompok kontrol 10.67 dan pada kelompok intervensi 10.25. Hasil uji Dependent T-Test kelompok intervensi didapatkan p=0.069 (p>0.05) yang berarti tidak ada perbedaan yang bermakna pada kelompok intervensi, sedangkan kelompok kontrol didapatkan p=0.037 (p<0.05) yang berarti ada perbedaan yang bermakna pada kelompok kontrol. Hasil uji Independent T-Test didapatkan p=0.796 (p>0.05) yang berarti tidak ada perbedaan yang bermakna pada kelompok intervensi dan kontrol. Kesimpulan: Penggunaan aplikasi visiting patient tidak mempengaruhi tingkat stres pasien rawat inap di RS Margono Soekarjo, tetapi hanya menambah pengetahuan pasien yang setidaknya mampu merubah sikap dan pola pikir.
HERPES ZOSTER DENGAN MANIFESTASI KLINIS MENYERUPAI ILEUS PARALITIK: LAPORAN KASUS Sylviningrum, Thianti; Putranti, Ismiralda Oke; Ardianto, Ferdi Wiweko
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.9424

Abstract

Latar Belakang: Herpes zoster (HZ) adalah penyakit erupsi vesikuler yang mengenai kulit dan saraf tepi akibat reaktivasi dari Varicella Zoster Virus (VZV). Reaktivasi VZV dapat menyebabkan neuropati dan lesi kulit vesikular yang terdistribusi sesuai dengan dermatom saraf. Neuropati pada sistem saraf enterik yang jarang dijumpai dapat berupa pseudo-obstruksi intestinal dengan gambaran klinis Ileus paralitik. Kami melaporkan kasus HZ dengan gambaran klinis menyerupai Ileus paralitik yang apabila terlambat ditangani akan meningkatkan morbiditas dan mortalitas penderitanya. Presentasi Kasus: Seorang laki-laki berusia 59 tahun datang ke Instalasi Gawat Darurat Rumah Sakit dengan keluhan perut teraba keras, dinding tegang, nyeri, tidak bisa kentut dan defekasi diikuti plenting isi air dari perut sampai punggung kanan. Hasil pemeriksaan fisik menunjukkan penurunan bising usus, dan erupsi lesi vesikuler dengan dasar kulit eritem terdistribusi dermatomal T8-10 dekstra. Pemeriksaan darah menunjukkan peningkatan monosit dan gula darah sewaktu, sedangkan hasil pemeriksaan radiologi abdomen tampak pelebaran usus besar dan distribusi udara normal di kolon. Hasil tes Tzanck dijumpai sel datia berinti banyak. Penderita didiagnosis HZ dan menunjukkan perbaikan setelah diberi asiklovir dan gabapentin. Simpulan: Neuropati pada sistem saraf enterik karena VZV perlu dipertimbangkan pada gambaran klinis Ileus paralitik disertai lesi kulit vesikuler yang patognomonik untuk HZ
POTENSI PELARUT ETIL ASETAT PADA EKSTRAKSI FLAVANOID DARI TANAMAN CIPLUKAN (Physalis angulata L.) Sylviningrum, Thianti; Rianto, Bayu Dwi; Agamonanza, Freddy; Ardinas, Shinta Prima
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11407

Abstract

The ciplukan plant (Physalis flavonoi L.) is widely used as a traditional medicine because it contains various bioactive compounds such as flavonoids and physalin. The purpose of this study was to identify and measure the total flavonoid content of ciplukan extracts in various solvents. Ciplukan was extracted by maceration using ethanol, n-hexane and ethyl acetate solvents. Flavonoids were identified by UV-Vis spectrophotometry at 510 nm wavelength. Total flavonoid content was measured based on the calibration curve of quercetin as the standard of comparison. The highest yield of ciplukan extract was obtained from ethanol solvent (18.5%), followed by n-hexane and ethyl acetate. The highest absorbance and total flavonoid content were found in the ethyl acetate extract, which were 0.1162 and 3,709.01 μg/g. Flavonoids from Ciplukan extract were identified most optimally in the semipolar solvent ethyl acetate compared to the polar solvent ethanol and nonpolar n-hexanes. The conclusion of this study is that ethyl acetate extract has the potential to be developed as an herbal medicinal material.
Optimalisasi Peran Kader Posyandu Lansia Dalam Deteksi Dini Hiperkolesterolemia Untuk Mencegah Penyakit Jantung Di Wilayah Kerja Puskesmas Sumbang II Setiawati, Setiawati; Candrawati, Susiana; Sylviningrum, Thianti; Ati, Viva Ratih Bening; Wulandari, Leni; Ardinas, Shinta Prima; Bestari, Gita
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 2 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.2.2.13305

Abstract

Hiperkolesterolemia merupakan faktor risiko utama penyakit jantung pada lansia. Deteksi dini melalui skrining rutin sangat penting, namun seringkali terkendala oleh keterbatasan sumber daya. Pengabdian masyarakat ini bertujuan untuk mengoptimalkan peran kader posyandu lansia dalam deteksi dini hiperkolesterolemia di wilayah kerja Puskesmas Sumbang II. Kegiatan meliputi pelatihan penggunaan alat pengukur kolesterol digital dan edukasi tentang hiperkolesterolemia kepada 40 kader posyandu dari 8 desa. Hasil menunjukkan peningkatan pengetahuan kader sebesar 16,25% dan 95% peserta mampu melakukan pemeriksaan kolesterol secara mandiri. Skrining awal menemukan 52,6% peserta memiliki kadar kolesterol >200 mg/dl. Program ini berhasil meningkatkan kapasitas kader dalam melakukan deteksi dini hiperkolesterolemia, yang diharapkan dapat berkontribusi pada pencegahan penyakit jantung pada lansia di wilayah kerja Puskesmas Sumbang II, Banyumas Kata kunci: Hiperkolesterolemia, Kader Posyandu, Lansia, Deteksi Dini, Penyakit Jantung
Pemberdayaan Ekonomi Penyandang Thalasemia di Banyumas Raya Melalui Kegiatan Pelatihan Usaha Kain Ecoprint dan Shibotik Lestari, Diyah Woro Dwi; Rujito, Lantip; Sulistyo, Hidayat; Faiza, Dinar; Sylviningrum, Thianti
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 2 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.2.2.13478

Abstract

Penyandang thalassemia menghadapi tantangan yang signifikan terutama tantangan fisik, psikologis dan ekonomi. Keterbatasan fisik dan kewajiban melakukan transfusi darah secara rutin membatasi para penyandang dalam kegiatan ekonomi. Keterbatasan partisipasi ini dimungkinkan berpengaruh pada kondisi perekonomian mereka. Tim pengabdian masyarakat dari Fakultas Kedokteran Universitas Jenderal Soedirman berinisiatif untuk menginisiasi kegiatan yang sekiranya dapat menjawab tantangan ini. Kegiatan yang dimaksudkan ialah pelatihan keterampilan pembuatan kain shibori dan ecoprint bagi anggota perkumpulan penyandang thalasemia di Banyumas Raya. Tujuan dilakukan kegiatan ini selain untuk meningkatkan kemampuan dan keterampilan usaha kain shibori dan ecoprint, juga untuk mengakrabkan sesama anggota perkumpulan dan memperluas jejaring. Tim Pengabdi berkerja sama dengan Perkumpulan Penyandang Talasemia Indonesia (PPTI) cabang Banyumas. Metode yang dilakukan meliputi pemberian materi di kelas, praktek bersama ahli dan diskusi mengenai potensi pengembangan usaha. Peserta pelatihan mengapresiasi upaya tim pengabdi dan memberikan evaluasi secara kualitatif.
Co-Authors Agamonanza, Freddy Ardianto, Ferdi Wiweko Ardinas, Shinta Prima Bestari, Gita Dara AisyahRahayu Abdurrachman Dody Novrial Dody Novrial, Dody Dwi Utami Anjarwati Eman Sutrisna Faiza, Dinar Fajar Wahyu Pribadi Fareza, Muhamad Salman Farissa Utami Fitranto Arjadi Fitranto Arjadi Hasnah Mutfii Hatmoko, Sito Hidayat Sulistyo Ika Murti Harini Irse Priyaganda Bani Musa Irse Priyaganda Bani Musa Ismiralda Oke Putranti Lantip Rujito Lestari, Diyah Woro Dwi Lily Kusumawati Burkon Miko Ferine Muhamad Salman Nor Sri Inayati, Nor Sri Octavia Permata Sari Putri Nur'afni Sa'adah Rahayu Nurmalia Fauziah Rianto, Bayu Dwi Setia Wati Setiawati Setiawati Suprihatin Suprihatin Susiana Candrawati Triasari Oktavriana Viva Ratih Bening Ati Wahyu Dwi Kusdaryanto Wahyu Siswandari Wahyudin Wahyudin Wahyudin Wahyudin Wulandari, Leni Yudhi Wibowo