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All Journal Pharmaciana: Jurnal Kefarmasian Farmasains : Jurnal Ilmiah Ilmu Kefarmasian
Lestari, Pramulani Mulya
fakultas farmasi dan Sains UHAMKA
Medicine & Pharmacology

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Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability Lestari, Pramulani Mulya; Yati, Kori; Savira, Nanda
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.003 KB) | DOI: 10.12928/pharmaciana.v8i1.9138

Abstract

As a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is added with a thickening agent to create transdermal dosage form. This study aimed to compare the physical stabilities of ketoconazole microemulsions formed with different thickeners, namely Carbopol 934 and Carbopol 941. The formula used varying concentrations of Carbopol 934 and Carbopol 941, i.e., 0.15% and 0.25%. The stability was observed during eight-week storage in which the conditions were controlled by different degrees of temperature, i.e., 40C, 25-300C (room temperature), and 400C. The stability tests included organoleptic observation, pH, surface tension, viscosity, particle size, and zeta potential. Based on the Kruskal-Wallis test results, ketoconazole microemulsion with Carbopol 941 that had been stored in different temperature showed a significant difference in particle size (significance value< 0.05), but it did not apply to Carbopol 934. The evaluation revealed that compared to 0.25% of Carbopol 934, microemulsion with 0.15% of Carbopol 934 had a smaller difference between the time intervals. This research concluded that the use of 0.15% of Carbopol 934 as a thickener in ketoconazole microemulsion had better physical stability compared to Carbopol 941 due to the influence of temperature and length of storage.
VARIASI KONSENTRASI ASAM SITRAT SEBAGAI SUMBER ASAM TERHADAP SIFAT FISIK TABLET EFFERVESCENT EKSTRAK KERING KULIT BUAH MANGGIS (Garcinia mangostana L) gusmayadi, inding; lestari, pramulani mulya; trisnande, erike
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 2 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.004 KB) | DOI: 10.22236/farmasains.v3i2.3321

Abstract

Asam sitrat digunakan sebagai sumber asam karena mudah bereaksi sehingga meningkatkan waktu melarut dalam sediaan tablet effervescent. Pada penelitian ini ekstrak dibuat menjadi sediaan tablet effervescent yang bertujuan untuk mengetahui apakah peningkatan konsentrasi asam sitrat sebagai sumber asam dapat memperbaiki sifat fisik tablet effervescent. Ekstrak kering kulit buah manggis yang diperoleh dimaserasi dengan air kemudian dibuat serbuk dengan spray drying. Ekstrak kering yang diperoleh dibuat menjadi 5 formula tablet effervescent dengan konsentrasi asam sitrat yang berbeda yaitu, 15%, 20%, 25%, 30% dan 35%. Tablet yang sudah jadi kemudian dievaluasi sifat fisiknya, meliputi uji organoleptik, keseragaman bobot, keseragaman ukuran, kekerasan, kerapuhan dan waktu melarut. Hasil evaluasi uji waktu melarut yang diperoleh dari formula 1 hingga formula 5 yaitu 10,50±0,57 menit, 4,52±1,04 menit, 3,32±0,13 menit, 3,13±0,14 menit dan 3,42±0,14 menit. Dari data analisa statistik waktu melarut ANAVA satu arah dengan taraf kepercayaan 95% menunjukkan bahwa adanya perbedaan dari kelima formula. Dapat disimpulkan bahwa peningkatan konsentrasi asam sitrat sebagai sumber asam dapat meningkatkan sifat fisik tablet yaitu meningkatkan waktu melarut, sedangkan asam sitrat dengan konsentrasi 35% dapat menurunkan waktu melarut tablet effervescent ekstrak kering kulit buah manggis (Garcinia mangostana L.).
Co-Authors Inding Gusmayadi Kori Yati Savira, Nanda trisnande, erike