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Correlation of diuretic therapy toward clinicaloutcomeof patients suffering from chronic kidney disease hospitalized in RSUP DR. M. Djamil Padang Sani K., Fathnur; Nazar, Armenia; Haque, Aina Fatkhil
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRACTKidney is one of the most important organs of the human body. The goal of diuretic therapy is to reduce edema in patients with impaired renal function. The therapy of diuretic is very important, because the therapy is effective to control of the volume of extracellular fluid, reduce protein exretion in urine and reduce on effects of hyperceluler complications. The purpose of this research is to provide information on the effect of giving diuretics with clinical outcome of patient with cronic kidney disease. The research was conducted by using longitudinal observational study design. Longitudinal observation is a method that perform data retrieval by a prospective census method with daily follow up until patient returns. The result of research showed that the most widely used diuretic was furosemide. Then the results also showed improvement of blood pressure, pulse, respiration rate, creatinine and urea although the results were not statistically significally (p>0.05). Mortality rate of the subjects in RSUP DR. M.Djamil Padang Hospital was very small. Patient with diuretic and without diuretic have equal mortality rate (p>0.05).Keyword: Kidney, CKD, Outcome, Diuretic

Hubungan Pengobatan Stroke dengan Jenis Stroke dan Jumlah Jenis Obat Reslina, Isra; Almasdy, Dedy; ,, Armenia
Jurnal Ipteks Terapan Vol 9, No 1 (2015): JIT
Publisher : LLDIKTI Wilayah X

Tujuan penelitian ini adalah untuk melihat hubungan efektifitas pengobatan stroke dengan jenis stroke dan jumlah jenis obat pada pasien rawat inap di bangsal syaraf RSUP Dr. M. Djamil Padang.Â Penelitian bersifat observatinal descriptif analitic melibatkan 47 orang pasien stroke rawat inap di bangsal syaraf RSUP Dr. M. Djamil Padang selama tahun 2011 (data retrospektif) dan periode Mei-Juli 2012 (data prospektif). Analisa data menggunakan uji Chi Square untuk melihat hubungan antara jenis stroke dan jumlah jenis obat dengan lama hari rawat, outcome tekanan darah dan outcome motorik. Hasil penelitian menunjukkan bahwaÂ pasien stroke hemoragik memerlukan lama hari rawat yang lebih panjang dibandingkan stroke iskemik (p<0,05), namun tidak terdapat perbedaan bermakna antara tekanan darah dan aktivitas motorik pasien antara ke dua jenis stroke ini (p>0,1). Pasien yang menggunakan obat dalam jumlah yang banyak, memilki lama hari rawat yang lebih panjang dibandingkan dengan pasien yang menggunakan jumlah obat yang sedikit (p<0,05). Namun tidak terdapat perbedaan bermakna antara jumlah jenis obat dengan tekanan darah dan aktivitas motorik pasien (p>0,1).Kata Kunci : aktivitas motoriknya; lama hari rawat; tekanan darah; terapy strokeThe purpose of this research is to see the relation of the effectiveness of the treatment of a stroke with a kind of a stroke and those kinds of drugs on inpatients in ward nerve RSUP Dr .M .DjamilÂ West Sumatera.Research is observatinal descriptif analitic involving 47 patients a stroke to be hospitalised in nerve UnitÂ RSUP Dr .M .DjamilÂ the last year 2011 and the period of ( data retrospective ) May - July ( data prospective ) Data analysis using the chi square to see the relationship between kind of stroke and the number of the type of medicines with long day for inpatient , blood pressure and motor outcome. The result showed that hemorrhagic stroke patient need for inpatient long day more long in proportion to a stroke ischemic ( p < 0.05 ) , but there is no meaningful difference between blood pressure and motor activity patients into two types of stroke between ( p > 0.1 ) .Patients with medicine in the amount that many, have long day for longer compared with patients with the quantity of medicine a slight ( p < 0.05 ) .But there is no meaningful difference between the total number of drugs with blood pressure and motor activity patients ( p > 0.1 ).Keywords : blood pressure;Â long day care;Â motor activity; therapy stroke

The Sub Acute Toxicity Study of Purified Gambir (Uncaria gambir Roxb.) to Liver Histology and its Reversibility on Rats Dita Permatasari; Indri Oktavia; Armenia Nazar; Almahdy Ahmadin
Bioscience Vol 5, No 1 (2021): Biology
Publisher : UNIVERSITAS NEGERI PADANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/0202151111642-0-00

Purified gambir proved to have many pharmacological activities and has the potential to be developed into standardized herbal medicines. This study was conducted to determine the safety of purified gambir to the liver histology. A total of 30 female white rats were used which divided into 4 groups: one control group and 3 test groups treated with purified gambir at doses of 5, 10 and 20 mg/kgbw orally for 14 days respectively. On the scheduled days, three animals from each group were killed for liver histological examination. The degree of liver damage and liver organ ratio in this study where were measured. The reversibility of liver damage was observed from the change in the value of the damage degree and liver organ ratio after the administration of gambir was stopped. Data were analyzed using two-way ANOVA followed by Duncan (significance were taken at p<0.05). The administration of purified gambir in rats for 14 days at tested groups caused significant damage to liver tissue (p<0.05). In this situation, the degree of tissue damage increased and the liver organ ratio decreased in all tested groups. After the administration was stopped, the degree of liver damage is decreased insignificantly, meanwhile the liver organ ratio is significantly increased.

Optimalisasi Performa Produksi Broiler yang Dipelihara dalam Kondisi Heat Stress Menggunakan Antioksidan Alami ‘Kalincuang’ Akhis Soleh Ismail; Yose Rizal; Armenia Armenia; Anwar Kasim
Jurnal Peternakan Vol 19, No 1 (2022): Februari 2022
Publisher : State Islamic University of Sultan Syarif Kasim Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24014/jupet.v19i1.15051

ABSTRAK. ‘Kalincuang’ adalah limbah cair yang dihasilkan dari proses pembuatan gambir (Uncaria gambir). Penelitian ini bertujuan untuk melihat peran ‘kalincuang’ sebagai antioksidan alami untuk mengoptimalkan performa produksi broiler yang dipelihara dalam kondisi heat stress. Rancangan yang digunakan adalah rancangan acak lengkap (RAL) dengan 6 perlakuan dan 4 ulangan. Perlakuan yang digunakan terdiri dari P1: 0 ppm ‘kalincuang’ (kontrol negatif), P2: 250 ppm vitamin C (kontrol positif), P3, P4, P5, dan P6 adalah pemberian ‘kalincuang’ dengan kadar 125, 250, 500, dan 1000 ppm. Ayam yang digunakan adalah broiler pejantan CP 707 berumur 21 hari. Ayam dipelihara dalam kandang baterai yang terbuat dari besi dan seng. Untuk membuat kondisi heat stress digunakan suhu kandang 36oC selama 8 jam/hari. Pakan dan air minum diberikan secara adlibitum dan pemberian ‘kalincuang’ maupun vitamin C dilakukan melalui air minum. Ayam dipelihara selama 2 minggu (21-35 hari). Mingu pertama adalah masa adaptasi dan minggu kedua adalah masa koleksi. Parameter yang diamati terdiri atas konsumsi pakan, konsumsi air minum, pertambahan berat badan (PBB), FCR (Feed convertion ratio), berat hidup, dan mortalitas. Rataan berat badan umur 35 hari tertinggi pada P5 sebesar 1602,5 g, PBB tertinggi pada P5 sebesar 375 g, total konsumsi pakan tertinggi pada P3 sebesar 863 g, konsumsi air minum terendah pada P6 sebesar 241 mL, FCR terendah pada P6 sebesar 1,95 dan mortalitas terendah terdapat pada P2, P5 dan P6 dengan mortalitas sebesar 0%. Dari hasil ini dapat disimpulkan bahwa ‘kalincuang’ dapat digunakan untuk mengoptimalkan performa produksi broiler yang dipelihara dalam kondisi heat stress dengan kadar pemberian 500 ppm.Kata kunci: Antioksidan, broiler, gambir, heat stress, ‘kalincuang’, performaOptimization of Broiler Production Performance Reared Under Heat Stress Conditions Using Natural Antioxidants 'Kalincuang' ABSTRACT. 'Kalincuang' is a liquid by-product from the process of making gambier (Uncaria gambir). This study aims to look at the role of 'kalincuang' as a natural antioxidant to optimize the production performance of broilers maintained in heat stress conditions. The design used is a completely randomized design (CRD) with 6 treatments and 4 repeats. The treatment used consisting of P1: 0 ppm 'kalincuang' (negative control), P2: 250 ppm vitamin C (positive control), P3, P4, P5, and P6 is the administration of 'kalincuang' with levels of 125, 250, 500, and 1000 ppm. The chicken used is a 21-day-old CP 707 male broiler. Broilers are kept in battery cages made of iron and zinc. To make heat stress conditions used cage temperature 36oC for 8 hours/day. Feed and drinking water are given ad-libitum and the administration of 'kalincuang' and vitamin C is done through drinking water. Broilers are kept for 2 weeks (21-35 days). The first week is the adaptation period and the second week is the collection time. The observed parameters consisted of feed consumption, drinking water consumption, weight gain, Feed conversion ratio (FCR), life weight, and mortality. The highest average body weight at 35 days of age was at P5 at 1602.5 g, the highest PBB was at P5 at 375 g, the highest total feed intake was at P3 at 863 g, the lowest water intake at P6 was 241 mL, the lowest FCR at P6 was 1, 95 and the lowest mortality was in P2, P5 and P6 with a mortality of 0%. These results it can be concluded that 'kalincuang' can be used to optimize the production performance of broilers maintained in heat stress conditions with a given level of 1000 ppm.

Correlation of diuretic therapy toward clinicaloutcomeof patients suffering from chronic kidney disease hospitalized in RSUP DR. M. Djamil Padang Fathnur Sani K.; Armenia Nazar; Aina Fatkhil Haque
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRACTKidney is one of the most important organs of the human body. The goal of diuretic therapy is to reduce edema in patients with impaired renal function. The therapy of diuretic is very important, because the therapy is effective to control of the volume of extracellular fluid, reduce protein exretion in urine and reduce on effects of hyperceluler complications. The purpose of this research is to provide information on the effect of giving diuretics with clinical outcome of patient with cronic kidney disease. The research was conducted by using longitudinal observational study design. Longitudinal observation is a method that perform data retrieval by a prospective census method with daily follow up until patient returns. The result of research showed that the most widely used diuretic was furosemide. Then the results also showed improvement of blood pressure, pulse, respiration rate, creatinine and urea although the results were not statistically significally (p>0.05). Mortality rate of the subjects in RSUP DR. M.Djamil Padang Hospital was very small. Patient with diuretic and without diuretic have equal mortality rate (p>0.05).Keyword: Kidney, CKD, Outcome, Diuretic

Hubungan Pengobatan Stroke dengan Jenis Stroke dan Jumlah Jenis Obat Isra Reslina; Dedy Almasdy; Armenia ,
Jurnal Ipteks Terapan Vol 9, No 1 (2015): JIT
Publisher : LLDIKTI Wilayah X

Tujuan penelitian ini adalah untuk melihat hubungan efektifitas pengobatan stroke dengan jenis stroke dan jumlah jenis obat pada pasien rawat inap di bangsal syaraf RSUP Dr. M. Djamil Padang. Penelitian bersifat observatinal descriptif analitic melibatkan 47 orang pasien stroke rawat inap di bangsal syaraf RSUP Dr. M. Djamil Padang selama tahun 2011 (data retrospektif) dan periode Mei-Juli 2012 (data prospektif). Analisa data menggunakan uji Chi Square untuk melihat hubungan antara jenis stroke dan jumlah jenis obat dengan lama hari rawat, outcome tekanan darah dan outcome motorik. Hasil penelitian menunjukkan bahwa pasien stroke hemoragik memerlukan lama hari rawat yang lebih panjang dibandingkan stroke iskemik (p<0,05), namun tidak terdapat perbedaan bermakna antara tekanan darah dan aktivitas motorik pasien antara ke dua jenis stroke ini (p>0,1). Pasien yang menggunakan obat dalam jumlah yang banyak, memilki lama hari rawat yang lebih panjang dibandingkan dengan pasien yang menggunakan jumlah obat yang sedikit (p<0,05). Namun tidak terdapat perbedaan bermakna antara jumlah jenis obat dengan tekanan darah dan aktivitas motorik pasien (p>0,1).Kata Kunci : aktivitas motoriknya; lama hari rawat; tekanan darah; terapy strokeThe purpose of this research is to see the relation of the effectiveness of the treatment of a stroke with a kind of a stroke and those kinds of drugs on inpatients in ward nerve RSUP Dr .M .Djamil West Sumatera.Research is observatinal descriptif analitic involving 47 patients a stroke to be hospitalised in nerve Unit RSUP Dr .M .Djamil the last year 2011 and the period of ( data retrospective ) May - July ( data prospective ) Data analysis using the chi square to see the relationship between kind of stroke and the number of the type of medicines with long day for inpatient , blood pressure and motor outcome. The result showed that hemorrhagic stroke patient need for inpatient long day more long in proportion to a stroke ischemic ( p < 0.05 ) , but there is no meaningful difference between blood pressure and motor activity patients into two types of stroke between ( p > 0.1 ) .Patients with medicine in the amount that many, have long day for longer compared with patients with the quantity of medicine a slight ( p < 0.05 ) .But there is no meaningful difference between the total number of drugs with blood pressure and motor activity patients ( p > 0.1 ).Keywords : blood pressure; long day care; motor activity; therapy stroke

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