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All Journal Jurnal Ilmiah Kesehatan Masyarakat JURNAL BIOSAINSTEK
Monika Putri Solikah
Universitas ‘Aisyiyah Yogyakarta
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Analysis of the Effectiveness of Garlic (Allium sativum) and Turmeric (Curcuma longa) Extracts as Antifungal Agents Against Candida albicans: Constraints and Inhibiting Factors Maria Indriani Bupu; Sri Martuti; Monika Putri Solikah
BIOSAINSTEK Vol 7 No 2 (2025): Jurnal BIOSAINSTEK
Publisher : UNIVERSITAS MUHAMMADIYAH MALUKU UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52046/biosainstek.v7i2.2524

Abstract

Candidiasis is an infection caused by the fungus Candida albicans and can attack various parts of the body such as skin, hair, nails, mucous membranes, and internal organs. The use of synthetic antifungal drugs is common in treating this infection, but causes unwanted side effects, therefore alternative treatments based on natural ingredients are needed that are safer and more effective. Garlic (Allium sativum) and turmeric (Curcuma longa) contain bioactive compounds such as allicin and curcumin which have the potential as antifungal agents. The purpose of this study was to determine the effectiveness of garlic (Allium sativum) and turmeric (Curcuma longa) extracts in inhibiting Candida albicans fungus. This study used 3 treatment groups, namely the control group, the garlic (Allium sativum) and turmeric (Curcuma longa) groups with each extract concentration of 20%, 40%, 60% and 80% with six repetitions. Extraction using maceration method with 96% ethanol solvent, while antifungal activity test was conducted using disc diffusion method on Sabouraud Dextrose Agar (SDA) media. Inhibition zone was observed after incubation for 24 hours in an incubator with a temperature of 37 °C. The results showed that garlic and turmeric extracts did not produce inhibition zone against Candida albicans growth. This ineffectiveness was caused by several factors, including the processing of materials, the use of high concentration ethanol solvent, testing method, and the absence of quantitative analysis of active compound content. These factors affect the decrease in the effectiveness of active compounds in the extract, so that it is unable to inhibit the growth of Candida albicans.
Analisis Hasil Uji Sensitivitas Bakteri pada Ulkus Penderita Diabetes Melitus Tipe 2 di Salah Satu Rumah Sakit Yogyakarta Fadhilah Zalfa Cahyaningrum; Dhiah Novalina; Monika Putri Solikah
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 4 No. 3 (2025): Juli 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v4i3.6153

Abstract

Diabetic ulcers are a condition that occurs in individuals suffering from diabetes mellitus due to damage to the nerves and peripheral arteries, leading to wound infections and damage to the skin tissue. The focus of this research is to determine the prevalence by gender, the types of bacteria that infect diabetic ulcers, and the patterns of antibiotic sensitivity at a hospital in Yogyakarta in 2024. This research employs a descriptive analytic design using a cross-sectional approach. The sampling technique uses total sampling, selecting all members of the population who meet inclusion and exclusion criteria. The data for this study were obtained from medical records during the period from January 1st to December 31st, 2024, with a total sample size of 86 diabetic ulcer patients. Of these patients, 53 are male and 33 are female who suffer from Type 2 Diabetes Mellitus with complications of diabetic ulcers. In addition, this research found 26 types of bacteria, where gram-negative bacteria are more dominant with 51 samples, while gram-positive bacteria amount to 35 samples. The most dominant type of gram-negative bacteria detected is Escherichia coli, while the most commonly identified gram-positive bacteria is Staphylococcus aureus. The antibiotics that are sensitive to gram-negative bacteria are meropenem, cefepime, and chloramphenicol. Meanwhile, the effective antibiotics against gram-positive bacteria are linezolid, gentamicin, and ciprofloxacin.
Co-Authors Dhiah Novalina Fadhilah Zalfa Cahyaningrum Maria Indriani Bupu Sri Martuti