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All Journal Hydrogen: Jurnal Kependidikan Kimia Jurnal Sains dan Kesehatan
Lestari, Wahyu Yunita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology Medicine & Pharmacology

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Sintesis, Molecular Docking dan Aktivitas Sitotoksik Senyawa Analog Kalkon Berbasis Alfa Tetralone terhadap Sel Kanker Payudara MCF-7: Synthesis, Molecular Docking, and Cytotoxic Activity of Alpha Tetralone Based Chalcone Analogue Compounds against MCF-7 Breast Cancer Cells Rahmadani, Agung; Tasya, Indriana; Lestari, Wahyu Yunita; Kadir, Nurdianah Abdul; Saputri, Mitha; Erika, Farah; Usman, Usman; Sukemi, Sukemi; Arifian, Hanggara; Salam, Supriatno; Herman, Herman; Rijai, Laode
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2092

Abstract

The chalcone compound is a precursor of flavonoid and pyrazoline compounds. Chalcone has two aromatic rings (A and B) and one ?,?-unsaturated carbon atom. Chalcone compounds can be synthesized via the Claisen Schmidt condensation reaction. Chalcone synthesis uses the basic ingredients of alpha tetralone and benzaldehyde analogues. In this research, chalcone synthesis took place for 48 hours at room temperature. Synthetic materials using ethanol solvent and sodium hydroxide catalyst, as well as basic ingredients alpha tetralone, 3,4-dimethoxybenzaldehyde and 4-methoxybenzaldehyde. Characterization of synthesized compounds using spectroscopic methods, including 1H-NMR, 13C-NMR, Fourier Transform Infrared (FTIR) and mass spectroscopy. Characterization results using spectroscopic methods showed that the two chalcone analogue compounds were successfully synthesized with yields above 70%. Both chalcone compounds showed low activity against MCF-7 cancer cells. Molecular docking simulations showed that both chalcone analogues produced energy levels and intramolecular interactions that were no better than 4-hydroxytamoxifen. Keywords:          chalcone analogues, alpha tetralone, cytotoxic   Abstrak Senyawa kalkon merupakan salah satu prekursor dari senyawa flavonoid dan pirazolina. Kalkon mengandung dua cincin aromatis (A dan B) dan satu atom karbon ?,?-tak jenuh. Senyawa kalkon dapat disintesis melalui reaksi kondensasi Claisen Schmidt. Kalkon disintesis menggunakan bahan dasar alfa tetralone dan analog benzaldehida. Dalam penelitian ini senyawa kalkon disintesis selama 48 jam pada suhu ruang menggunakan pelarut etanol dan katalis natrium hidroksida serta bahan dasar alfa tetralone, 3,4-dimetoksibenzaldehida dan 4-metoksibenzaldehida.  Senyawa hasil sintesis dikarakterisasi menggunakan metode spektroskopi meliputi 1H-NMR, 13C-NMR, Fourier Transform Infrared (FTIR) dan spektroskopi massa. Karakterisasi menggunakan metode spektroskopi menunjukkan kedua senyawa analog kalkon berhasil disintesis dengan rendemen diatas 70%. Hasil pengujian sitotoksik menunjukkan bahwa kedua senyawa analog kalkon tidak aktif terhadap sel kanker payudara MCF-7. Simulasi penambatan molekuler menunjukkan bahwa kedua analog kalkon menghasilkan tingkat energi dan interaksi intramolekuler yang tidak lebih baik dibandingkan dengan 4-hidroksitamoksifen. Kata Kunci:         analog kalkon, alfa tetralone, sitotoksik
The Effect of Collaborative Problem Solving Learning Model on Students' Collaboration Skills in Chemistry Learning Lestari, Wahyu Yunita; Erika, Farah; Rahmadani, Agung
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 3 (2025): June 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i3.15784

Abstract

The low collaboration skills of students are due to the less-than-optimal role of the teacher in fostering interpersonal skills and cooperation in the classroom. Selecting an appropriate learning model is key to effectively enhancing students' collaboration skills. Therefore, the Collaborative Problem Solving (CPS) learning model optimizes students' collaboration skills. This study aims to determine the effect of the Collaborative Problem Solving (CPS) model on students' collaboration skills in elements, compounds, and mixtures. The approach employed is a quasi-experimental design utilizing a non-equivalent control group format. All 8th-grade junior high school students in Samarinda for the 2023/2024 academic year served as the population in this study. Class VIII A was assigned as the experimental group, whereas Class VIII B was the control group. The sample was selected using purposive sampling based on the subject teacher’s considerations, including classroom participation, group collaboration, and peer interaction. The instrument used was a collaboration skills questionnaire consisting of 25 statement items, utilizing a 5-point Likert scale. Data collection was also carried out using an observation sheet developed based on the indicators of collaboration skills. The data were analyzed descriptively after being collected through observations and collaboration skill questionnaires. The findings indicated that the experimental group achieved a higher average score than the control group, indicating that the CPS model syntax positively improved students' collaboration skills.
Co-Authors Arifian, Hanggara Farah Erika Herman Kadir, Nurdianah Abdul Laode Rijai Rahmadani, Agung Salam, Supriatno Saputri, Mitha Sukemi Sukemi Tasya, Indriana Usman Usman