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All Journal PROSIDING SEMINAR KIMIA Jurnal Sains dan Kesehatan
Kadir, Nurdianah Abdul
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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LITERATURE REVIEW: DEVELOPMENT OF GAMIFICATION LEARNING MEDIA IN CHEMISTRY Yulian, Satifa Ananda; Rengganis, Ajeng Ayu; Hazlina, Nur; Siburian, Putri Dela; Kadir, Nurdianah Abdul; Rahmadani, Agung
PROSIDING SEMINAR KIMIA Vol 2 No 1 (2023): Prosiding SNK 2023
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Science and technology evolved with the times and has very important influence in various aspects of life, one of them is the aspect in education. Utilization of science and technology in education can be applied through innovation in developing learning media. Gamification-based learning media is a game designed as a learning instrument. Gamification is one of the learning media innovations that can be utilized in chemistry learning for increase motivation and student learning outcomes. The writing of this literature review purposed for examining the development of gamification learning media in chemistry learning. The method used in this literature review is narrative literature review by collecting data of article related to gamification learning media that published within a period 2014-2023. Data analysis is carried using an simplified approach. The articles used in this literature review were 51 articles from accredited national and international journals obtained from Google Scholar. Based on the result of the literature review, it was found that gamification learning media can increase student motivation in chemistry learning. Gamification can also motivate teacher to innovate in creating learning media that can interest student. Therefore, gamification can be a new trend in chemistry learning. Keywords: gamification; chemistry learning media; education game
Sintesis, Molecular Docking dan Aktivitas Sitotoksik Senyawa Analog Kalkon Berbasis Alfa Tetralone terhadap Sel Kanker Payudara MCF-7: Synthesis, Molecular Docking, and Cytotoxic Activity of Alpha Tetralone Based Chalcone Analogue Compounds against MCF-7 Breast Cancer Cells Rahmadani, Agung; Tasya, Indriana; Lestari, Wahyu Yunita; Kadir, Nurdianah Abdul; Saputri, Mitha; Erika, Farah; Usman, Usman; Sukemi, Sukemi; Arifian, Hanggara; Salam, Supriatno; Herman, Herman; Rijai, Laode
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2092

Abstract

The chalcone compound is a precursor of flavonoid and pyrazoline compounds. Chalcone has two aromatic rings (A and B) and one ?,?-unsaturated carbon atom. Chalcone compounds can be synthesized via the Claisen Schmidt condensation reaction. Chalcone synthesis uses the basic ingredients of alpha tetralone and benzaldehyde analogues. In this research, chalcone synthesis took place for 48 hours at room temperature. Synthetic materials using ethanol solvent and sodium hydroxide catalyst, as well as basic ingredients alpha tetralone, 3,4-dimethoxybenzaldehyde and 4-methoxybenzaldehyde. Characterization of synthesized compounds using spectroscopic methods, including 1H-NMR, 13C-NMR, Fourier Transform Infrared (FTIR) and mass spectroscopy. Characterization results using spectroscopic methods showed that the two chalcone analogue compounds were successfully synthesized with yields above 70%. Both chalcone compounds showed low activity against MCF-7 cancer cells. Molecular docking simulations showed that both chalcone analogues produced energy levels and intramolecular interactions that were no better than 4-hydroxytamoxifen. Keywords:          chalcone analogues, alpha tetralone, cytotoxic   Abstrak Senyawa kalkon merupakan salah satu prekursor dari senyawa flavonoid dan pirazolina. Kalkon mengandung dua cincin aromatis (A dan B) dan satu atom karbon ?,?-tak jenuh. Senyawa kalkon dapat disintesis melalui reaksi kondensasi Claisen Schmidt. Kalkon disintesis menggunakan bahan dasar alfa tetralone dan analog benzaldehida. Dalam penelitian ini senyawa kalkon disintesis selama 48 jam pada suhu ruang menggunakan pelarut etanol dan katalis natrium hidroksida serta bahan dasar alfa tetralone, 3,4-dimetoksibenzaldehida dan 4-metoksibenzaldehida.  Senyawa hasil sintesis dikarakterisasi menggunakan metode spektroskopi meliputi 1H-NMR, 13C-NMR, Fourier Transform Infrared (FTIR) dan spektroskopi massa. Karakterisasi menggunakan metode spektroskopi menunjukkan kedua senyawa analog kalkon berhasil disintesis dengan rendemen diatas 70%. Hasil pengujian sitotoksik menunjukkan bahwa kedua senyawa analog kalkon tidak aktif terhadap sel kanker payudara MCF-7. Simulasi penambatan molekuler menunjukkan bahwa kedua analog kalkon menghasilkan tingkat energi dan interaksi intramolekuler yang tidak lebih baik dibandingkan dengan 4-hidroksitamoksifen. Kata Kunci:         analog kalkon, alfa tetralone, sitotoksik
Co-Authors Arifian, Hanggara Farah Erika Hazlina, Nur Herman Laode Rijai Lestari, Wahyu Yunita Rahmadani, Agung Rengganis, Ajeng Ayu Salam, Supriatno Saputri, Mitha Siburian, Putri Dela Sukemi Sukemi Tasya, Indriana Usman Usman Yulian, Satifa Ananda