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All Journal Jurnal Ilmiah Fillia Cendekia Pharmaceutical Sciences and Research (PSR)
Lestari, Indah Dewi
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Immunology & microbiology Veterinary Other

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Beyond Use Date (BUD) Determination of Ambroxol Hydrochloride Syrup by High-Performance Liquid Chromatography – UV/VIS Detector Jatmika, Catur; Iswandana, Raditya; Lestari, Indah Dewi
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Ambroxol HCl is a mucolytic agent often used to treat respiratory disorders associated with excess mucus secretion. This study aims to determine the beyond-use date (BUD) of ambroxol HCl syrup on the market based on analysis of the decrease in drug content using High-Performance Liquid Chromatography (HPLC) – UV/Vis detector. The HPLC conditions were reversed-phase with a C18 column, mobile phase containing acetonitrile - phosphate buffer 0.05 M pH 4.5 (60:40) at a flow rate of 1.0 ml/min using UV detection at 248 nm. To determine BUD, five syrup preparations (brands) obtained from the Jakarta area were analyzed in triplicate. The retention time for ambroxol HCl was 4.62 minutes. In the validation, ambroxol HCl showed good linearity with r = 0.99985 in the 6 to 36 µg/ml. LOD and LOQ for ambroxol HCl were 0.74 µg/ml and 2.25 µg/ml, respectively. It is also fulfilled the accuracy and precision parameters with a % recovery from 99.04% to 100.94% and CV<2%. This method meets the requirements according to the ICH Q2(R1) guidelines and can be used for the assay of ambroxol HCl syrup. The ambroxol HCl level on all samples was still higher than 90% (until the 36th day). Normality test data result indicated that data must be divided into two groups that are sample A and B, and sample C, D, and E. In conclusion, the extrapolation result showed that the BUD ambroxol HCl syrup was 83 days for sample A and B, and 49 days for sample C, D, and E.
Substitusi Tepung Terigu Dengan Tepung Millet Kuning (Panicum milliaceim L. ) Terhadap Kualitas Fisik Nugget Ayam Lestari, Indah Dewi; Lestariningsih, lestariningsih; Putra, Fatra Nonggala
Jurnal Ilmiah Fillia Cendekia Vol 10 No 1 (2025): Jurnal Ilmiah Fillia Cendekia
Publisher : Universitas Islam Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32503/fillia.v10i1.5492

Abstract

Penelitian subsitusi tepung terigu dengan tepung millet kuning (Panicum milliaceim L.) terhadap kualitas fisik nugget ayam ini bertujuan untuk mengetahui pengaruh dari tepung millet kuning sebagai subtitusi tepung terigu terhadap kualitas fisik nugget ayam. Rancangan percobaaan yang dilakukan dalam penelitian ini yakni Rancangan Acak Lengkap (RAL) dengan 5 perlakuan 4 kali ulangan yang terdiri dari P0: 100% tepung terigu tanpa pemberian tepung millet kuning, P1: 25% tepung millet kuning 75% tepung terigu, P2: 50% tepung millet kuning 50% tepung terigu, P3: 75% tepung millet kuning 25%tepung terigu, dan terakhir P4: 100% tepung millet kuning tanpa pemberian tepung terigu. Subsitusi yang diberikan tidak memberikan berpengaruh pada semua pengujian (P>0,05). Rasa nugget ayam yang paling disukai adalah pemberian 25% tepung millet kuning 75% tepung terigu. Aroma yang paling disukai adalah pemberian tepung 25% tepung millet kuning 75% tepung terigu. Sedangkan Tekstur dan warna yang paling disukai pemberian 100% tepung terigu tanpa pemberian tepung millet kuning. Semakin tinggi konsentrasi subsitusi tepung millet kuning maka berpengaruh pada penurunan skor kesukaan secara keseluruhan pengujian nugget
Co-Authors Catur Jatmika, Catur FATRA NONGGALA PUTRA Lestariningsih Lestariningsih Raditya Iswandana