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Putu Wika Pramesti Iswari
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Mechanical Engineering Public Health

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Heart-type Fatty Acid-binding Protein (H-FABP) sebagai Diagnostik Awal dan Prognostik Infark Miokard Akut Ni Made Utami Wulandari; Putu Wika Pramesti Iswari; Yusra Pintaningrum
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2622

Abstract

Acute myocardial infarction (AMI) remains one of the leading causes of mortality and morbidity worldwide. Early diagnosis and accurate prognosis are vital to improve patient outcomes. Heart-type Fatty Acid-binding Protein (H-FABP) has emerged as a potential biomarker for AMI. H-FABP is a cytoplasmic protein encoded by the FABP3 gene, situated on chromosome 1 in the human genome. It plays a crucial role in active fatty acid metabolism and is implicated in the absorption, cellular metabolism, and/or transport of polyunsaturated fatty acids (PUFAs). During the pathogenesis of acute coronary syndrome (ACS), H-FABP is rapidly released into the circulation when myocardial ischemic injury occurs. Its early detection, around 1-2 hours after AMI, with a peak at 5-10 hours, and normalization within 24-36 hours, makes H-FABP an ideal candidate for early diagnostic and prognostic evaluation in AMI patients. Despite its excellent prognostic value, H-FABP's diagnostic sensitivity outweighs its specificity for AMI. This review discusses the potential of H-FABP as an early diagnostic and prognostic marker for AMI and emphasizes further studies and research are needed regarding the use of H-FABP as a diagnostic and/or prognostic marker for AMI.
Diabetes Melitus Tipe 2 dengan Hipertiroid dan Hipertensi: Case Report Akelba, Shalsa Damai; Putu Wika Pramesti Iswari; Adam Trojan Alisyahbana; Aulia Dwi Hendriani; Baiq Ramdhani Amelia Negara; Grandis Cristagalli1, Izza Mufida; M. Andre Darmawan; Nadia Safira; Ni Putu Visty Wedhiani; Rike Delya Rizqina; Tri Sastra Pradhini; Indah Sapta Wardani
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2782

Abstract

Diabetes mellitus (DM) is high levels of glucose in the blood (hyperglycemia) accompanied by disturbances in carbohydrate, lipid, protein metabolism as a result of insufficiency of insulin function which can be caused by impaired or deficient insulin production by beta cells in the pancreas or can also be caused by a lack of responsiveness of insulin cells. The prevalence of diabetes mellitus is 9.3% or around 463 million people suffer from diabetes in 2019. One of the risk factors for diabetes mellitus is hyperthyroidism and hypertension. The right treatment for patients suffering from type 2 diabetes mellitus with hyperthyroidism and hypertension is to reduce glucose levels, blood pressure, and reduce the production of the thyroid gland
Co-Authors Adam Trojan Alisyahbana Akelba, Shalsa Damai Aulia Dwi Hendriani Baiq Ramdhani Amelia Negara Grandis Cristagalli1, Izza Mufida Indah Sapta Wardani M. Andre Darmawan Nadia Safira Ni Made Utami Wulandari Ni Putu Visty Wedhiani Rike Delya Rizqina Tri Sastra Pradhini Yusra Pintaningrum