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All Journal Global Medical and Health Communication Padjadjaran Journal of Dentistry
Djohan, Frita Ferlita Shafri
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Antibacterial and antibiofilm activity of mint leaves (Mentha piperita L) extracts against Streptococcus mutans UA159: a laboratory experiment Muhtar, Azmi Nur Azizah; Atthoriq, Adriansyah Altaf; Jeffrey, Jeffrey; Djohan, Frita Ferlita Shafri; Soerachman, Badi
Padjadjaran Journal of Dentistry Vol 36, No 1 (2024): March 2024
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol36no1.52744

Abstract

Introduction: Oral health is a major concern in healthcare worldwide, with dental caries being a prevalent issue among children and adults. Streptococcus mutans is a primary bacterium implicated in the development of dental caries due to its acidogenic nature. Mint leaf (Mentha piperita L.) is a unique herbal plant that has antibacterial and antibiofilm properties against S. mutans and minimal side effects. The purpose of this study was to analyze the antibacterial effectiveness of mint leaf against the growth of S. mutans UA159 and its antibiofilm effects. Methods: This study was conducted experimentally with the posttest-only control group design, using the broth microdilution method in 6 test groups, namely mint leaf extract with a concentration of 3.125, 6.25, 12.5, 25, 50, and 100% and also two control groups, namely the negative control using aquadest and the positive control using 0.2% chlorhexidine. Biofilm growth is determined by comparing Optical Density (OD) values and then calculating the percentage of eradication of S. mutans biofilm formation. Results: The results indicated that the mint leaf extract exhibited antibacterial effects against S. mutans, with the largest inhibition zone diameter observed at a 100% concentration. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC)90 values using the broth microdilution method in this study were 12.5% and 100% concentrations, respectively. Mint leaf extract has been shown to significantly inhibit the growth of S. mutans (p<0.05). The results of the inhibition test on biofilm formation at a concentration of 100% averaged 87.39%. Conclusion: Mint leaf extract has an antibacterial and antibiofilm effect on the growth of S. mutans. The level of inhibition of mint leaf extract on the growth of S. mutans is proportional to its concentration; the higher the concentration of the extract, the stronger the inhibitory ability.KeywordAnti-Bacterial agents, biofilms, Mentha piperita, oral health, Streptococcus mutans.
Effectiveness of Sage Leaf Gel on Neutrophil Count in Wound Healing Meliawaty, Florence; Djohan, Frita Ferlita Shafri; Ramdhani, Muhamad Syahrul
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14302

Abstract

A wound involves damage to the epithelial layer of the skin, extending to the subcutis and surrounding tissues. The body initiates a healing process starting with inflammation. Neutrophils play a crucial role in this phase; excessive neutrophils can cause tissue necrosis, while insufficient neutrophils may lead to infection. Neutrophils are essential for bacterial eradication during inflammation. Sage leaf extract, known for its anti-inflammatory, antioxidant, and antibacterial properties, may aid in wound healing. This study evaluates the effectiveness of 5% sage leaf extract gel on neutrophil count during the wound healing process in Wistar rats. This study was conducted in several Universitas Jenderal Achmad Yani Cimahi laboratories from 29 May 2023 to 23 February 2024. A post-test-only control group design was used with 25 samples divided into five groups: (K-1) no treatment, tissue sampled at 13 minutes; (K-2) no treatment, tissue sampled at 103 minutes; (KN) healthy/normal control; (KP1) 5% sage leaf extract gel, tissue sampled at 13 minutes; (KP2) 5% sage leaf extract gel, tissue sampled at 103 minutes. Data analysis was performed using the Kruskal-Wallis test followed by the Mann-Whitney post hoc test (p≤0.05), indicating a statistically significant difference. The highest mean neutrophil count was observed in the KP2 group, which received 5% sage leaf extract gel and had tissue sampled at 103 minutes. The study concludes that a 5% sage leaf extract gel is effective in increasing neutrophil counts during the healing of punch wounds in Wistar rats, which contributes to accelerated wound healing.
Effectiveness of Sage Leaf Gel on Neutrophil Count in Wound Healing Meliawaty, Florence; Djohan, Frita Ferlita Shafri; Ramdhani, Muhamad Syahrul
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14139

Abstract

A wound involves damage to the epithelial layer of the skin, extending to the subcutis and surrounding tissues. The body initiates a healing process starting with inflammation. Neutrophils play a crucial role in this phase; excessive neutrophils can cause tissue necrosis, while insufficient neutrophils may lead to infection. Neutrophils are essential for bacterial eradication during inflammation. Sage leaf extract, known for its anti-inflammatory, antioxidant, and antibacterial properties, may aid in wound healing. This study evaluates the effectiveness of 5% sage leaf extract gel on neutrophil count during the wound healing process in Wistar rats. This study was conducted in several Universitas Jenderal Achmad Yani Cimahi laboratories from 29 May 2023 to 23 February 2024. A post-test-only control group design was used with 25 samples divided into five groups: (K-1) no treatment, tissue sampled at 13 minutes; (K-2) no treatment, tissue sampled at 103 minutes; (KN) healthy/normal control; (KP1) 5% sage leaf extract gel, tissue sampled at 13 minutes; (KP2) 5% sage leaf extract gel, tissue sampled at 103 minutes. Data analysis was performed using the Kruskal-Wallis test followed by the Mann-Whitney post hoc test (p≤0.05), indicating a statistically significant difference. The highest mean neutrophil count was observed in the KP2 group, which received 5% sage leaf extract gel and had tissue sampled at 103 minutes. The study concludes that a 5% sage leaf extract gel is effective in increasing neutrophil counts during the healing of punch wounds in Wistar rats, which contributes to accelerated wound healing.
Co-Authors Atthoriq, Adriansyah Altaf Badi Soerachman, Badi Florence Meliawaty Jeffrey ., Jeffrey Muhtar, Azmi Nur Azizah Ramdhani, Muhamad Syahrul