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Fernandes, Ângela
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Genotoxic and Cytotoxic Potential of Smoke Crack Cocaine on the Epithelium of the Human Oral Mucosa de Lima, Raphaela Cássia; Ferraz, Priscila; Chaiben, Cassiano Lima; Fernandes, Ângela; Grégio, Ana Maria Trindade; Machado, Maria Ângela Naval; Azevedo-Alanis, Luciana Reis; de Lima, Antonio Adilson Soares
Journal of Dentistry Indonesia Vol. 23, No. 2
Publisher : UI Scholars Hub

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Crack cocaine is an illicit drug derived from cocaine. It can produce some damages to the lungs and oral cavity. Objective: The aim of this study was to analyze the frequency of micronuclei and some nuclear alterations in epithelial cells of crack cocaine users. Methods: Oral smears were collected from clinically normal-appearing buccal mucosa exfoliative cytology of 30 individuals (15 crack cocaine users and 15 controls). Results: Crack cocaine users consumed about 3.8 grams per day and the time consumption of the drug was of 6.4 (+3.3) years. The prevalence of micronuclei, binucleated cells, broken egg cells, budding cells, picnosis, karyolysis, and karyorrhexis was determined. The frequencies of micronuclei for case and control groups were, respectively, 2.87 + 3.46 and 0.57 + 1.6 (p=0.018). No statistical difference was observed for binucleated cells, broken egg cells, budding cells, picnosis, and karyolysis. The frequency of karyorrhexis was significantly increased on crack cocaine users than controls (54.07 + 38.58 and 24.87 + 23.97, p=0.001). Conclusion: Smoke crack might have a cytotoxic and genotoxic effects to the oral mucosa due to increased frequency of micronuclei and karyorrhexis. Thus, individuals who used crack cocaine in the long term need to be frequently examined in order to prevent neoplastic transformation.
Structures Suggestive of Carotid Artery Calcifications and Their Prevalence on Digital Panoramic Radiographs Adad, Luana P.V.; Oliveira, Lucas B.; Orestes, Sther G.; Vetter, Flávia; Franco, Ademir; Makeeva, Irina; Fernandes, Ângela
Journal of Dentistry Indonesia Vol. 26, No. 1
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Objectives: To investigate prevalence of carotid artery calcifications via digital panoramic radiographs of patientswho underwent dental treatment. Methods: Panoramic radiographs of 12.687 patients who underwent dentaltreatment at a federal university, were collected (male, n = 5.169, 40.7%; female, n = 7.518, 59.3%). Patients wereaged 2–87 years (mean age, 34 years). Radiographs were obtained using a digital device. Two trained examinersanalyzed the images with an imaging software package. Radiopaque images in the C3 and C4 cervical vertebraeregion were searched for. Statistical outcomes were analyzed based on their association with sex and age. Results: The prevalence rate of carotid artery calcifications was 1.8% (n = 227). We identified unilateral (n = 140, 61.67%)and bilateral (n = 87, 38.33%) calcifications. Prevalence and sex (130 females, 97 males) were not statisticallysignificant (p > 0.05). We observed calcifications predominantly in patients aged 50–60 years (p < 0.05). Conclusion: Awareness by physicians and dentists of the possible presence of carotid artery calcifications on digital panoramicradiographs is necessary. To optimize the risk management of vascular diseases, asymptomatic patients in theirfifties or sixties must receive additional attention because panoramic radiographs may lead to diagnosis.
Assessing the Radiographic Position of the Mental Forament in a Brazillian Population Pasquali, Jordan Gasparetto; Narazaki, Nathan Dyoji; Franco, Ademir; Vieira, Iran; Fernandes, Ângela; de Lima, Antonio Adilson Soares
Journal of Dentistry Indonesia Vol. 24, No. 1
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The mental foramen is a clinically important landmark for several clinical dental procedures. The aim of this study is to assess the anatomic position of the mental foramen (MF) in panoramic radiographs of a Brazilian population. The sample consisted of 2,100 panoramic radiographs, obtained from 8,600 clinical files from the School of Dentistry at the Universidade Federal do Paraná. Two calibrated examiners investigated the MF according to the classification of Tebo and Telford, which locates the right and left MF into 6 different positions in relation to the apex of the adjacent teeth. Results: The MFs were similarly distributed between the apices of the mandibular premolars (class III) and below the apex of the mandibular second premolar (class IV). More specifically, on the right side 41.8% (n = 878) of the MFs were classified as class III, while 47.52% (n = 998) were classified as class IV. On the left side 42.47% (n = 892) were classified as class III, while 47.38% (n = 995) were classified as class IV. The results indicate that MFs are often located adjacent to the apex of the mandibular second premolar. However, slight variations may occur in the positioning of the MF to the mesial direction. Clinicians and surgeons must be aware of the position of the MF and its potential variations prior to anaesthetics and surgical procedures in the mandible.
Co-Authors Adad, Luana P.V. Azevedo-Alanis, Luciana Reis Chaiben, Cassiano Lima de Lima, Antonio Adilson Soares de Lima, Raphaela Cássia Ferraz, Priscila Franco, Ademir Grégio, Ana Maria Trindade Machado, Maria Angela Naval Makeeva, Irina Narazaki, Nathan Dyoji Oliveira, Lucas B. Orestes, Sther G. Pasquali, Jordan Gasparetto Vetter, Flávia Vieira, Iran