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All Journal Biogenesis: Jurnal Ilmiah Biologi BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal MedScientiae
Sabini, Jasmine Harumi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Caenorhabditis elegans sebagai Model Hewan Penelitian Biologi dan Biomedis Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3467

Abstract

Caenorhabditis elegans is a microscopic nematode, with a transparent body, short life span, self-fertilization ability. C. elegans is easy to be cultured and has been used as an animal model for molecular research, medicine, pharmacology, and toxicology. In addition, C. elegans was the first animal to have its genome completely sequenced and has played a major role in understanding apoptosis and RNA interference. The use of C. elegans as a biological model in environmental toxicology assessments has allowed for the determination of several endpoints. Some of these utilize effects on the biological functions of the nematode and others use molecular markers. Furthermore, C. elegans has enabled the assessment of neurotoxic effects for pesticides and heavy metals, since this nematode has a very well-defined nervous system. Overall, almost every known toxin has been tested in this animal model. In the near future, the knowledge available about the life cycle of C. elegans will allow for more studies on reproduction, transgenerational toxicity for newly developed chemicals and materials, and detailing the signaling pathways involved in the mechanisms of toxicity. C. elegans is an important animal model for research into the identification and understanding of the machinery of nuclear transport. This has helped elucidate biochemical pathways involved in diseases such as obesity, diabetes, and Alzheimer's disease. C. elegans is an excellent animal model for studying aging because of its short lifespan, susceptibility to oxidative stress, and similarity to the human aging process.
The Role of Flavonoids as Immunomodulatory Agents: Therapeutic Potential and Mechanisms of Action Sabini, Jasmine Harumi; Susilowati, Rina Priastini; Sari, Monica Puspa
Jurnal MedScientiae Vol. 4 No. 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3710

Abstract

Flavonoids are a group of polyphenolic compounds widely found in plants and have long been recognized for their biological activities, including antioxidant and anti-inflammatory effects. In recent years, increasing attention has been given to the potential of flavonoids as immunomodulatory agents. This review article aims to summarize and evaluate scientific evidence regarding the role of flavonoids in modulating both innate and adaptive immune responses. Several flavonoids, such as apigenin, genistein, quercetin, and naringenin, have been shown to suppress the production of proinflammatory cytokines, inhibit macrophage activation, and influence the differentiation of T cell subpopulations such as Th1, Th2, Th17, and Treg. In addition, some flavonoids have been found to inhibit inflammasome activation and may promote macrophage polarization toward either the M1 or M2 phenotype depending on the pathological context. Although preclinical data demonstrate promising results, challenges such as low bioavailability remain a major barrier to therapeutic application. Therefore, further research is needed to optimize the clinical potential of flavonoids as effective and safe immunomodulatory agents.
Protective effect of juwet fruit extract (Syzygium cumini L.) on duodenum histomorphometry and histopathology of male mice exposed to pyrantel pamoate Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
Biogenesis: Jurnal Ilmiah Biologi Vol 12 No 2 (2024)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v12i2.56552

Abstract

Pyrantel pamoate, known as an anthelmintic under the brand name Combantrin®, is effectively used to kill worms in the intestines. However, long-term use of it has been associated with side effects and risk of drug resistance. Syzygium cumini L.is known for its antioxidant and anti-inflammatory which may support antiparasitic effects and tissue healing. This study aims to examine the effect of juwet (S. cumini L.) fruit water extract (JFWE) on the duodenum structure of mice suspected to be infected with worm, through histomorphometric analysis and histopathological examination. The pyrantel pamoate was only administered once after the acclimatization period, while the JFWE was administered for 3 weeks. A total of 30 male mice were divided into six groups: negative control (aquadest), positive control (pyrantel pamoate, Combantrin® 20 mg/mL), and JFWE at doses of 5 mg/mL, 10 mg/mL, 20 mg/mL, and 40 mg/mL, administered for 3 weeks. Histomorphometric and histopathological evaluations were conducted by microscopically observing the duodenum structures, including intestinal villi, and the thickness of the mucosa, submucosa, and muscularis layers. The results showed a significant difference for the decrease in intestinal villi height and thickness of the mucosa, submucosa, and muscularis layers in JWFE doses of 5 mg/mL and 10 mg/mL administration group, compared to the negative control group (aquadest), the treatment groups of pyrantel pamoate, and JFWE doses of 20 mg/mL and 40 mg/mL (p<0.05). The conclusion is that the administration of juwet fruit water extract doses of 20 mg/mL and 40 mg/mL can improve the histomorphometry structure and also the histopathology of the duodenum of male mice.
EFFECT OF SYZYGIUM CUMINI AQUEOUS EXTRACT ON CARBON TETRACHLORIDE-INDUCED TESTICULAR DAMAGE IN MICE: A HISTOMORPHOMETRY Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 12 No. 1 (2025): Biolink August
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v12i1.14506

Abstract

The juwet fruit (Syzygium cumini) is a type of fruit commonly found in Indonesia and is known to contain high levels of antioxidant compounds, potential for protecting reproductive organs from oxidative damage. This study aims to investigate the effects of juwet fruit in protecting the testes from damage caused by CCl4 toxicity in mice. A total of 30 mice were used and divided into six groups: distilled water, 12.5 mg/mL CCl₄, and S. cumini extract at doses of 5, 10, 20, and 40 mg/mL for three weeks.  Parameters assessed included body weight, serum testosterone levels, sperm count, and histomorphometry (seminiferous tubule diameter, germinal epithelium height, and spermatogenic cell counts). The results showed that CCl₄ significantly reduced body weight, the number of spermatogenic cells in the seminiferous tubules, seminiferous tubule diameter, germ cell height, and serum testosterone levels in the mice. The treatment groups receiving extract of juwet fruit at doses of 20 mg/mL and 40 mg/mL showed improvements in testicular function that were not significantly different from the distilled water group. In conclusion, reproductive toxicity induced by CCl₄ in male mice can be ameliorated by administering aqueous extract of juwet fruit at doses of 20 mg/mL and 40 mg/mL.
Co-Authors Monica Puspa Sari Santoso, Adit Widodo Susilowati, Rina Priastini