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Review Article: URIC ACID HOMEOSTASIS AND DISTURBANCES Ferry Fredy Karwur; Dwi Rahayu Pujiastuti
Folia Medica Indonesiana Vol. 53 No. 4 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Airlangga

This review examined the homeostasis of uric acid in human body and analyzed recent studies of the affecting major variables. Normal uric acid concentration in male is 3.5-7.2 mg/dL and in female is 2.6-6 mg/dL. Daily turnover of normal uric acid ranges from 498-1392 mg/day, miscible pool is 767-1650 mg, reabsorption is 8064 mg/day, renal excretion is 262-620 mg/day and intestine 186-313 mg/day. The dynamics of uric acid is influenced by factors of food, drink, age, history of disease, and genetic. High purine dietary consumption increases blood uric acid by 1-2 mg/dL, 213-290 g/day fructose drinks increases 0.52-1.7 mg/dL, 1.5 g/kgBW sucrose increases 0.61 mg/dL, and 10-20 ml/kgBW beer increases 0.50-0.92 mg/dL. The ABCG2 gene plays a role in bringing uric acid out of the body by 114.31-162.73 mg/dL, SLC2A9 of 5.43-20.17 mg/dL, and SLC22A12 of 5.77-6.71 mg/dL. The data described the homeostasis of uric acid and the magnitude of the impact of environmental (consumption of food, beverages, and lifestyle) and genetic factors. Understanding uric acid homeostasis and its disturbances is important in managing diseases as a consequence of hyperuricemia and hypouryscemia

Review Article: URIC ACID HOMEOSTASIS AND DISTURBANCES Ferry Fredy Karwur; Dwi Rahayu Pujiastuti
Folia Medica Indonesiana Vol. 53 No. 4 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Airlangga

This review examined the homeostasis of uric acid in human body and analyzed recent studies of the affecting major variables. Normal uric acid concentration in male is 3.5-7.2 mg/dL and in female is 2.6-6 mg/dL. Daily turnover of normal uric acid ranges from 498-1392 mg/day, miscible pool is 767-1650 mg, reabsorption is 8064 mg/day, renal excretion is 262-620 mg/day and intestine 186-313 mg/day. The dynamics of uric acid is influenced by factors of food, drink, age, history of disease, and genetic. High purine dietary consumption increases blood uric acid by 1-2 mg/dL, 213-290 g/day fructose drinks increases 0.52-1.7 mg/dL, 1.5 g/kgBW sucrose increases 0.61 mg/dL, and 10-20 ml/kgBW beer increases 0.50-0.92 mg/dL. The ABCG2 gene plays a role in bringing uric acid out of the body by 114.31-162.73 mg/dL, SLC2A9 of 5.43-20.17 mg/dL, and SLC22A12 of 5.77-6.71 mg/dL. The data described the homeostasis of uric acid and the magnitude of the impact of environmental (consumption of food, beverages, and lifestyle) and genetic factors. Understanding uric acid homeostasis and its disturbances is important in managing diseases as a consequence of hyperuricemia and hypouryscemia

Hubungan antara Hiperusemia dengan Hiperglikemia pada Laki-Laki Suku Jawa Dwi Rahayu Pujiastuti; Ferry Fredy Karwur
Jurnal Ilmu Kesehatan Masyarakat Vol. 8 No. 3 (2017): Jurnal Ilmu Kesehatan Masyarakat
Publisher : Association of Public Health Scholars based in Faculty of Public Health, Sriwijaya University

Latar Belakang: Prevalensi penyakit degeneratif terutama penyakit metabolik di Indonesia dalam 10 tahun terakhir semakin meningkat. Studi keterkaitan antara hiperurisemia dan hiperglikemia telah dilaporkan dalam konteks klinis dan sangat terbatas dalam konteks populatif. Penelitian ini bertujuan menganalisis prevalensi hiperurisemia, menganalisis hubungan antara asam urat, gula darah puasa serta faktor antropometrik lain yang memengaruhi pada laki-laki usia lanjut-manula Suku Jawa di Jawa Tengah, Indonesia.Metode: Penelitian dilakukan secara studi potong lintang (cross-sectional) terhadap laki-laki dari populasi umum di Desa Ngebung (Sragen, Jawa Tengah) berumur ≥ 50. Jumlah sampel sebesar 108 orang berasal dari total populasi laki-laki umur ≥ 50 sebesar 359 orang (30%) di desa tersebut (Jumlah total penduduk laki-laki di desa tersebut sebesar 1133). Pengukuran meliputi kadar asam urat darah, glukosa darah puasa, antropometri (tinggi badan, berat badan, lingkar pinggang, dan pinggul). Data dianalisis menggunakan statistik Kruskal Wallis, Spearman, dan Binary Logistic Regression.Hasil Penelitian: Hasil analisis menunjukkan prevalensi hipourisemia mencapai 2.8%, normal 46.3%, dan hiperurisemia 50.9%. Adapun prevalensi penderita hipoglikemia sebesar 3.7%, normoglikemia 49.1%, dan hiperglikemia 47.2%. Konsentrasi asam urat berhubungan positif dengan IMT (r=0.204, p < 0.05), GDP (r=0.184, p ≥ 0.05), dan RLPP (r=0.107, p > 0.05), tetapi variabel umur memiliki hubungan negatif (r=- 0.016, p > 0.05). Odds ratio menunjukkan penderita hiperurisemia berpeluang mengalami hiperglikemia 0.29 kali (confidence interval [CI] 95%, 0.12–0.69, p < 0.05) setelah dilakukan penyesuaian dengan faktor umur, RLPP, dan IMT.Kesimpulan: Pada laki-laki usia lanjut-manula di Desa Ngebung memiliki rata-rata konsentrasi asam urat yang tinggi (50.9% responden ≥ 7 mg/dL) dan hiperurisemia berhubungan positif dengan hiperglikemia.Kata kunci: Hubungan, hiperurisemia, hiperglikemia, suku jawa.

Pelatihan Ekonomi Kreatif Pembuatan Wine Salak Nanas dan Rempah-Rempah Sebagai Peluang Usaha Mario Nikolaus Dalengkade; Bayu Achil Sadjab; Dwi Rahayu Pujiastuti; Kurnia Kurnia; Nining Purwaningsih
Parta: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2023)
Publisher : Universitas Pendidikan Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38043/parta.v4i1.4231

The new economic era demands creativity that exceeds common expectations. Creative economy training such as processing pineapple, snake fruit and spices agricultural produce into wine is a breakthrough solution in increasing the economic value of a product. This insight is needed by generation Z who are leaning towards the creative economy era. The community service method covers two parts. The first is wine making training and the second is organoleptic testing of wine products. During the training process the participants were very enthusiastic in learning how to make snake fruit wine, pineapple and spices with being active in practicing and following each stage. The average results of the organoleptic test based on the level of preference for taste, aroma and color, the panelists liked the spiced wine the most by 4.73, 4.57 and 4.20 respectively. This activity was able to grow, motivate and add insight to participants in processing pineapples, snake fruit and spices into wine products as a business opportunity in the creative economy sector.

APPLICATION OF DETERMINISTIC MODEL FOR HYPERTENSION CASES Dalengkade, Mario Nikolaus; Hayati, Martina; Pujiastuti, Dwi Rahayu
BAREKENG: Jurnal Ilmu Matematika dan Terapan Vol 19 No 1 (2025): BAREKENG: Journal of Mathematics and Its Application
Publisher : PATTIMURA UNIVERSITY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/barekengvol19iss1pp345-352

World Health Organization (WHO) latest reports about hypertension as a global health problem, due to a spike in cases. One of the roles of mathematics in health is to provide information about the increase in hypertension sufferers. Using a deterministic model is supposed to provide information that can explain how the cases increase. The deterministic model used is divided into two equations. The first equation uses k as a constant. Second, is p for p < 1 and p > 1. The results from both equations are in the form of a logistic curve and show simulation results are similar to condition data for hypertension sufferers. In addition, the extended deterministic model with p <1 indicates that hypertension sufferers increase exponentially, thus an intervention step is needed.

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