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All Journal Jurnal Kesehatan Tambusai Jurnal Sains dan Teknologi Laboratorium Medik
Nashirah, Najwa
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Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Perbedaan Sampel Hemolisis dan Non Hemolisis terhadap Nilai Prothombin Time (PT) pada Mahasiswa Poltekkes Kaltim Nashirah, Najwa
Jurnal Sains dan Teknologi Laboratorium Medik Vol 10 No 2 (2024): November 2024
Publisher : Akademi Kesehatan John Paul II Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52071/jstlm.v10i2.167

Abstract

Haemolysis is the rupture of erythrocyte cells which results in the erythrocytes releasing haemoglobin into the serum or plasma. Haemolysed samples will affect pre-analytical errors in many laboratories. According to the Clinical Laboratory and Standards Institute (CLSI), in the Prothombin Time (PT) and Activated Partial Thromboplastin Time (APTT) testing guidelines, haemolysed samples should not be used for examination due to the potential activation of clotting factors and interference at the end of the measurement point. The purpose of this study was to determine the difference in the results of Prothombin Time (PT) examination in haemolysis samples with non-hemolysis. This type of research is a quasi-experimental design. The research design used is Nonequivalent Control Group Design, which is a design that takes measurements in treated and untreated groups. The samples used in this study were blood sodium citrate haemolysis and non-hemolysis as many as 39 specimens. Data normality analysis using Shapiro Wilk. Paired T-Test test to determine the difference between haemolysis and non-haemolysis samples. The results of this study showed that the average Prothombin Time value of non-hemolysis samples was 15 seconds, mild hemolysis samples were 9 seconds and moderate hemolysis was 8 seconds. In the univariate test results, the results were shortened in mild haemolysis and moderate haemolysis samples. In the bivariate test results obtained normal distributed results and obtained there is a difference in Prothombin Time values in hemolysis and non-hemolysis samples. The conclusion of this study is that there is a significant difference in hemolysis and non-hemolysis samples on the value of Prothombin Time with p value <0.05. Keywords: Haemolysis, Photo Optic, Prothombin Time
PERBEDAAN NILAI PEMERIKSAAN ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) DENGAN MENGGUNAKAN SAMPEL DARAH NON HEMOLISIS HEMOLISIS DAN HEMOLISIS Prihandono, Dwi Setiyo; Ameliawati, Afika; Nashirah, Najwa
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.47884

Abstract

Sampel yang hemolisis akan berpengaruh terhadap kesalahan pra-analitik di banyak laboratorium. Menurut Clinical Laboratory and Standards Institute (CLSI),pedoman pengujian untuk Activated Partial Thromboplastin Time (APTT) sampel hemolisis tidak boleh digunakan untuk dilakukan pemeriksaan karena adanya potensi aktivasi faktor pembekuan dan gangguan pada akhir titik pengukuran. Tujuan penelitian ini untuk mengetahui perbedaan nilai pemeriksaan Activated Partial Thromboplastin Time (APTT) dengan menggunakan sampel darah non hemolisis dan hemolisis. Jenis penelitian yang digunakan dalam penelitian ini bersifat Eksperimen Semu (Quasi Eksperimental Design). Desain penelitian yang digunakan adalah Nonequivalent Control Group Desaign yaitu desain yang melakukan pengukuran pada kelompok yang diberi perlakuan dan tidak diberi perlakuan. Sampel yang digunakan dalam penelitian ini adalah 13 sampel darah dengan antikoagulan natrium sitrat yang diberi perlakuan non hemolisis, hemolisis rigan dan dan hemolisis sedang sebanyak total 39 perlakuan. Analisis normalitas data menggunakan Shapiro wilk. Uji T test berpasangan digunakan untuk mengetahui perbedaan sampel non hemolisis dan hemolisis. Hasil penelitian ini didapatkan rata-rata nilai Activated Partial Thromboplastin Time (APTT) sampel Non Hemolisis dengan nilai 30 detik, sampel hemolisis ringan 20,7 detik, dan sampel hemolisis sedang 20,5 detik. Pada hasil uji univariat didapatkan hasil memendek pada sampel hemolisis ringan dan hemolisis sedang. Pada hasil uji bivariat didapatkan hasil terdistribusi normal dan pada uji T test berpasangan didapatkan adanya perbedaan nilai Activated Partial Thromboplastin Time (APTT) pada sampel hemolisis dan non hemolisis dengan p value < 0,05. Kesimpulan penelitian ini adalah ada perbedaan yang signifikan pada sampel non hemolisis dan hemolisis terhadap hasil nilai Activated Partial Thromboplastin Time (APTT).
Co-Authors Ameliawati, Afika Prihandono, Dwi Setiyo