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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran
Syarifah Nurul Yanti Rizki Syahab Assegaf
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Uji Aktivitas Antibakteri Air Perasan Jeruk Siam Sambas terhadap Escherichia coli Bimo Hendrayana; Mistika Zakiah; Syarifah Nurul Yanti Rizki Syahab Assegaf; Delima Fajar Liana; Mahyarudin Mahyarudin
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 2 No. 1 (2025): Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v2i1.1021

Abstract

Escherichia coli is a bacterium that typically resides as a normal flora in the gastrointestinal tract of humans and animals. However, certain strains of E. coli can cause infections in humans. Therefore, antibiotics are needed to inhibit the growth of these infection-causing bacteria. The increasing cases of antibiotic resistance in E. coli necessitate alternative therapies, including the use of natural substances. In West Kalimantan, one potential source is the Pontianak Orange (Citrus nobilis var. microcarpa). This plant contains secondary metabolites that can be used for medicinal purposes, such as the juice extract. The compounds within these secondary metabolites possess antimicrobial properties that could be used as antibacterials. To determine the antibacterial potential of Pontianak Orange juice (Citrus nobilis var. microcarpa) against Escherichia coli. This study utilized an experimental design featuring a post-test only group design. Phytochemical analysis indicated that Pontianak Orange juice (Citrus nobilis var. microcarpa) contains phenolics (+), alkaloids (+), and terpenoids (++). Antibacterial activity testing at all concentrations (25%, 50%, 75%, and 100%) showed no inhibition zones. The juice of Pontianak Orange (Citrus nobilis var. microcarpa) did not show antibacterial effects against the growth of Escherichia coli bacteria.
EFFECTIVENESS OF ETHANOL EXTRACT OF PURPLE EGGPLANT SKIN AS AN ANTIMALARIAL ON LIVER SIZE IN MICE INDUCED WITH Plasmodium berghei Taniyo, Nurul Fadhilah; Muhammad In'am Ilmiawan; Muhammad Ibnu Kahtan; Sari Rahmayanti; Syarifah Nurul Yanti Rizki Syahab Assegaf
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.454

Abstract

Malaria is caused by the protozoa Plasmodium through the bite of the Anopheles mosquito, with one of the symptoms being an enlarged liver. This study aims to test the effectiveness of ethanol extract of purple eggplant (Solanum melongena L.) skin on the liver size of mice (Mus musculus) induced by Plasmodium berghei. Extraction was carried out by maceration using 70% ethanol. Mice were divided into treatment groups (extract doses of 0.075 mg/20 gBW, 0.15 mg/20 gBW, and 0.3 mg/20 gBW), positive control (DHP 3.744 mg/20 gBW), negative control (aquades), and normal control. Observations included parasitemia levels as well as liver weight, volume, and index. The results showed that the extract dose affected the liver size of mice. There was no significant correlation between parasitemia and liver weight (p=0.073) and volume (p=0.133), but there was a significant correlation with liver index (p=0.002). This study recommends further studies on the potential of active compounds in purple eggplant as hepatoprotective and antimalarial agents.
Co-Authors Bimo Hendrayana Delima Fajar Liana Mahyarudin, Mahyarudin Mistika Zakiah Muhammad Ibnu Kahtan Muhammad In'am Ilmiawan Sari Rahmayanti Taniyo, Nurul Fadhilah