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All Journal JOURNAL OF HEALTH SCIENCE (JURNAL ILMU KESEHATAN) Respiratory Science
Bies, Asri Liqditta
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Health Professions Medicine & Pharmacology Nursing

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The Nucleic Acid Amplification Test in Pulmonary Diseases Nurwidya, Fariz; Bies, Asri Liqditta; Winardi, Wira; Harinda, Fadlika
Journal Of Health Science (Jurnal Ilmu Kesehatan) Vol 9 No 2 (2024): JOURNAL OF HEALTH SCIENCE (JURNAL ILMU KESEHATAN)
Publisher : Fakultas Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24929/jik.v9i2.3606

Abstract

Nuclei as a cell nucleus have been found since the 18th century. This discovery was then developed for the need for methods for diagnosing pathogenic organisms of an infectious disease at that time. The aim of this study is to review the principle of nucleic acid amplification test and describe the existing evidence regarding the role of the test in respiratory diseases. The study use the keywords, such as nucleic acid, diagonsis and nucleic acid amplification test, to invesitage relevant studies in PubMed and Google Scholar database. We found that nucleic acid-based testing techniques have evolved to adapt to the need for early and rapid detection and rely on a high level of accuracy. This continuously developed technology can replace conventional test methods. Conventional examination is known to take longer time so the definitive therapeutic might be delayed. However, there is still an obstacle, namely the cost of tests quite expensive because of the standard procedure that must be strictly followed, otherwise result might not be valid. The technique from the beginning needs to be carried out following the procedure, starting with the preparation of tools, how to take samples, how to deliver the samples to the laboratory, and how to process and analyze data. This procedure is necessary to minimize false positive or negative results. As a conclusion, nucleic acid assays is beneficial in pulmonary infectious diseases diagnosis, however it is high-cost and not recommended for treatment evaluation in pulmonary infection.
The Evolution of Transbronchial Lung Biopsy Guidance Alatas, Mohammad Fahmi; Bies, Asri Liqditta; Prasenohadi, Prasenohadi; Soehardiman, Dicky; Aniwdyaningsih, Wahju; Elhidsi, Mia; Desianti, Ginanjar Arum; Reisa, Tina; Rasmin, Menaldi
Respiratory Science Vol. 5 No. 2 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i2.170

Abstract

Histological confirmation of lung lesions is necessary prior to determining further management. Imaging preparation is needed to find the biopsy site such as a computed tomography scan. Imaging helps to trace the position of lung lesions that are peripheral and not visualized by bronchoscope. However, along with the discovery of small lesions and peripheral location, two-dimensional imaging alone remains suboptimal. Therefore, to reach lung lesions peripherally would need to a guide through the bronchial. Subsequently, the method of guiding transbronchial biopsy evolved. Namely, real-time fluoroscopy, radial-probe endobronchial ultrasound, virtual bronchoscopy navigation and electromagnetic bronchoscopy navigation are guiding modalities with each of their advantages and disadvantages. Several biopsy modalities are used in combination to increase the accuracy of diagnosis. Careful analysis in planning and an understanding of the limitations and advantages of diagnostic modalities must be considered in deciding which method to choose.
Co-Authors Alatas, Mohammad Fahmi Aniwdyaningsih, Wahju Desianti, Ginanjar Arum Elhidsi, Mia Fariz, Nurwidya Harinda, Fadlika Menaldi Rasmin Prasenohadi, Prasenohadi Reisa, Tina Soehardiman, Dicky Wira Winardi, Wira