Article Per Year (5 Year)
p-Index From 2020 - 2025
1.642
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Brawijaya Medical Journal of Indonesia Majalah Kesehatan FKUB Journal of Islamic Medicine CRJIM (Clinical and Research Journal in Internal Medicine) Jurnal Penyakit Dalam Indonesia
Sasiarini, Laksmi
Fakultas Kedokteran Universitas Brawijaya
Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 13 Documents
Search

 1   2 
The Effect of Green Tea Extract Supplementation on PlasmaMalondialdehyde (MDA) in Human with Sub-Maximal PhysicalActivity, Double-Blind and Placebo-Controlled Trials Arsana, Putu Moda; Sasiarini, Laksmi; Nugraha, Bayu Eka
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Green Tea extract has been proven in vitro to have the ability as an antioxidant. Submaximal physical activity causes an increase in free radicals. The increase of MDA can detect the increase of free radicals. This study aimed to determine the effects of green tea extract supplementation against free radicals in submaximal physical activity by measuring plasma MDA. Methods. This double-blind controlled trial study was performed in 20 students of faculty of sports science with submaximal physical activity in the form of 1,500 meters running in 12 minutes using a treadmill. Subjects were divided into two groups: green tea extract group (250 mg) and the control group (placebo). Supplement/placebo was given as one caps a day for fourteen days before submaximal physical activity. The plasma MDA was taken before, 2 hours after, and 48 hours after the submaximal physical activity. Analysis of the results used ANOVA and post hoc Tukey. The study has been assessed by 24 | Jurnal Penyakit Dalam Indonesia | Vol. 6, No. 1 | Maret 2019 Putu Moda Arsana, Laksmi Sasiarini, Bayu Eka Nugraha Medical Research Ethical Committee at Medical Faculty of Universitas Brawijaya. Results. In the control group, the mean value of plasma MDA levels in basal conditions, 2 hours and 48 hours after submaximal physical activity were 52.43 nmol/ml (standard deviation [SD] 12.52 nmol/ml), 55.57 nmol/ml (SD 13.84 nmol/ml), and 63.86 nmol/ml (SD 12.17 nmol/ml), respectively. However, this result was not statistically significant (p = 0.158). In the treatment group, the mean value of plasma MDA level at 48 hours after submaximal physical activity was significantly decreased compared to basal condition with mean value in basal and 48 hours after submaximal physical activity were 36.14 nmol/ ml (SD 5.88 nmol/ml) and 19.86 nmol/ml (SD 8.92 nmol/ml), respectively (p <0.001). Further analysis showed a significant difference in plasma MDA levels between the two groups at basal, 2 hours, and 48 hours after submaximal physical activity (p values were 0.012; <0.001, and <0.001 respectively). Conclusion. Green tea extract can decrease the plasma level of MDA at basal, 2 hours, and 48 hours after submaximal physical activity.
Hiperglikemia pada Pasien Diabetes Melitus Tipe 1 dan 2 yang Menjalani Puasa Ramadan : Laporan Kasus Ahdi, Iwal Reza; Sasiarini, Laksmi
Journal of Islamic Medicine Vol 6, No 1 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i1.13741

Abstract

Background: Ramadan fasting is an obligation for every Muslim, including Muslim patients who suffer from diabetes mellitus. The most common complication in diabetic patients when fasting is hypoglycemia, but in special conditions, hyperglycemia can also occur, and even emergency occurs in both type 1 and type 2 diabetes patients. Purpose: To know the hyperglycemia complications in type 1 and 2 diabetes mellitus in Ramadhan fasting Methods: Reported a case of inpatient diabetes mellitus 1 and 2 who underwent fasting during Ramadan and complications of hyperglycemia occurred in dr. Saiful Anwar Hospital (RSSA) Malang during the month of Ramadan Results: Both patients experienced hyperglycemia which was a response to an increase in response to hypoinsulinemia in type 1 diabetes and an increase in glycogenolysis in DM type 2. Conclusion: Hyperglycemia can occur in patients with type 1 and 2 DM who fast during the month of Ramadan
Effect of a high-calorie diet on pro- to anti-inflammatory macrophage ratio through fat accumulation in rat lung tissue Lestari, Indah Puji; Chozin, Iin Noor; Sartono, Teguh Rahayu; Sasiarini, Laksmi; Yudhanto, Hendy Setyo
Medical Journal of Indonesia Vol. 32 No. 4 (2023): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.236991

Abstract

BACKGROUND A high-calorie diet increases the risk of obesity. Accumulation of fat causes inflammation, as seen by the increased ratio of pro- to anti-inflammatory macrophages in a high-calorie diet. The pro-inflammatory shift in macrophage polarization may result in hypoxia, fibrosis, emphysema, and asthma. This study aimed to determine the effect of a high-calorie diet on pro- to anti-inflammatory macrophage ratio through fat accumulation. METHODS This experimental study used in vivo test in 16 male Sprague-Dawley rats aged 10–12 weeks. The rats were divided into high-calorie and normal diet groups for 16 weeks. Obesity in rats was defined as having a body mass index (BMI) of >0.68 g/cm2. Examination of lung fat accumulation was done through oil red O staining, while pro- to anti-inflammatory macrophage ratio was tested through CD11c and CD206 expressions by immunohistochemical method. RESULTS The high-calorie diet group had higher BMI (0.72 [0.02] versus 0.62 [0.03]; p<0.001), lung fat accumulation (32.73 [10.55] versus 0.37 [0.38]; p<0.001), and pro- to anti-inflammatory macrophage ratio (0.83 [0.02] versus 0.24 [0.006]; p<0.001). The higher the fat accumulation, the higher the pro- to anti-inflammatory macrophage ratio (r = 0.933; p<0.001). CONCLUSIONS The ratio of pro- to anti-inflammatory was higher in the high-calorie diet group, indicating polarization of macrophages toward pro-inflammatory macrophages.
Co-Authors Achmad Rudijanto Ahdi, Iwal Reza Arsana, Putu Moda Bayu Eka Nugraha Brahmantyo, Herwindo Pudjo Bramantya, Rinadhi Reza Budianto, Rahmad Cholid Tjahjono Chozin, Iin Noor Djoko Wahono Soeatmadji Indah Puji Lestari Iwal Reza Ahdi Novita Lavi Nugraha, Bayu Eka Nurshanty, Ade Puspitasari, Ika A Putu Moda Arsana Putu Moda Arsana Rahmad Budianto Ricky C. Tarigan Rinadhi Reza Bramantya Rulli Rosandi Santoso, Aktaruddin Arief Sartono, Teguh Rahayu Sasongko, Ardi Simatupang, Charisma Dian Sri Andarini Sri Sunarti Tarigan, Ricky C. Yudhanto, Hendy Setyo