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All Journal PREPOTIF : Jurnal Kesehatan Masyarakat Journal of Pharmaceutical and Sciences.
Hilmi , Indah Laily
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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PREFERENSI KLINIS PEMILIHAN CETIRIZINE ATAU HLORPHENIRAMINE MALEAT DALAM PENGOBATAN ALERGI Shadrina, Jahra Almas; Hilmi , Indah Laily; Sudarjat, Hadi; Affandhy, Adhwa’a Kaylla; Dzannuba, Fadya Laila
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.37749

Abstract

Alergi adalah gangguan inflamasi kronis dengan reaksi kekebalan yang menyimpang terhadap bahan kimia lingkungan tertentu, yang disebut alergen. Antihistamin  seperti cetirizine dan chlorpheniramine maleat sering diresepkan untuk menangani alergi. Meskipun sama-sama merupakan antihistamin , keduanya memiliki perbedaan penting dalam hal efektivitas, profil efek samping, dan keamanan. Artikel review ini bertujuan untuk mengetahui frekuensi penggunaan cetirizine dan chlorpheniramine maleat di fasilitas kesehatan serta mengidentifikasi alasan di balik pemilihan masing-masing obat dalam pengobatan alergi. Metode yang digunakan adalah narrative review, dengan populasi pasien yang mengalami alergi dan memerlukan pengobatan dengan antihistamin  di suatu fasilitas pelayanan kesehatan dengan intervensi penggunaan cetirizine sebagai pilihan antihistamin  untuk mengatasi alergi dengan perbandingan penggunaan chlorpheniramine maleat sehingga diperoleh pemahaman mengenai preferensi klinis dalam memilih cetirizine atau chlorpheniramine maleat. Literatur diperoleh dari Google Scholar dan Publish or Perish, diikuti analisis bibliometrik menggunakan perangkat lunak VOSviewer. Hasil dari 13 jurnal yang diperoleh menunjukkan bahwa cetirizine lebih sering digunakan dibandingkan chlorpheniramine maleat. Efek sedasi yang rendah dan durasi kerja yang lebih lama (hingga 24 jam), menjadikan cetirizine pilihan lini pertama. Chlorpheniramine maleat, meskipun memiliki efek sedasi yang tinggi dan durasi kerja yang lebih singkat (4-6 jam), tetap digunakan dalam situasi tertentu karena harganya lebih terjangkau dan lebih mudah didapat.
Review Artikel: Perbandingan Efektivitas dan Efek Samping Pembrolizumab Kombinasi Kemoterapi Dengan Kemoterapi Tunggal Dalam Pengobatan Non-Small Cell Lung Cancer (NSCLC) Dzannuba, Fadya Laila; Hilmi , Indah Laily; Sudarjat , Hadi; Shadrina , Jahra Almas; Affandhy , Adhwa’a Kaylla
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.684

Abstract

This review article aims to compare the effectiveness and side effects of pembrolizumab combined with chemotherapy versus chemotherapy alone in the treatment of advanced Non-Small Cell Lung Cancer (NSCLC). A systematic review was conducted using literature published between 2015 and 2024. Relevant studies were identified through databases such as Google Scholar, using keywords like "Pembrolizumab," "Side Effects," "Effectiveness," "Overall Survival (OS)," and "Progression-Free Survival (PFS)." The results showed that pembrolizumab combined with chemotherapy significantly improved Overall Survival (OS) and Progression-Free Survival (PFS) compared to chemotherapy alone. However, this combination therapy was associated with a higher frequency of side effects, such as pneumonitis and hypothyroidism. In conclusion, pembrolizumab combined with chemotherapy offers superior efficacy in prolonging survival and controlling disease progression in advanced NSCLC. However, its use requires careful patient selection and close monitoring of toxicity. These findings support pembrolizumab as a promising first-line therapy for advanced NSCLC.
Interaksi Obat-Herbal dengan Agen Hormon dalam Terapi Kanker: Tinjauan Mekanisme dan Implikasi Klinis Zulqifli, Iqbal; Hikmah, Nurul; Shella, Tasya Permata; Azizah, Nabilla Faoziyyah; Apriani, Risa Dwi; Putri, Mukarromah Dita; Hilmi , Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1073

Abstract

Hormone therapy is the cornerstone of treatment for hormone-dependent cancers, such as breast and prostate cancer. On the other hand, the high rate of herbal medicine use as complementary treatment in cancer patients has the potential to cause herbal drug interactions (HDIs), which can affect the efficacy and safety of the primary therapy. This study aims to identify and categorize drug-herbal interactions (DHIs) in cancer hormone therapy based on pharmacokinetic mechanisms (including CYP450 enzyme and drug transporter modulation) and pharmacodynamic mechanisms (including hormone receptor and signaling pathway modulation), as well as to conclude their clinical implications. A systematic review was conducted following the PRISMA-ScR guidelines. A literature search was performed in the PubMed, Scopus, ScienceDirect, Frontiers, and Google Scholar databases for relevant in silico, in vitro, and in vivo studies published between 2015 and 2025. Analysis showed that HDI can be categorized into two main groups. First, pharmacokinetic interactions that occur through the modulation of cytochrome P450 (CYP) enzymes and drug transporters, such as the reduction in the bioavailability of tamoxifen by Hedyotis diffusa. Second, pharmacodynamic interactions at hormone receptors, such as the synergistic effect between Boswellia serrata and enzalutamide. The nature of interactions varies greatly, from antagonistic to synergistic, depending on the specific herbal-drug pair. These findings emphasize the importance of clinical vigilance, such as open communication with patients, dose adjustments, therapeutic monitoring, and interprofessional collaboration. These measures are necessary to reduce the risk of HDI and improve the efficacy of cancer therapy.
Literature review: faktor-faktor yang berhubungan dengan health-seeking behavior dan quality of life pada pasien penderita asma Sulistiawati, Sulistiawati; Hilmi , Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.368

Abstract

Background: Asthma affects approximately 335 million people worldwide and is the 14th most common disease globally in terms of disability, burden, and negative impact on individuals, society, and the economy. Asthma patients often experience a decline in condition due to sudden onset symptoms. Comorbid conditions such as depression and anxiety, changes in nighttime and early morning activities, and environmental factors such as cold air can affect the quality of life of asthma patients and influence their health-seeking behavior. Methods: This study used an observational design with a literature study approach. The databases used to obtain this article are PubMed and Scopus. Results: From the literature study results, 7 articles were analyzed that met the eligibility criteria according to the inclusion and exclusion criteria. The resulting factors are associated with health-seeking behavior and quality of life in asthma patients. Conclusion: This study states that factors associated with health-seeking behavior and quality of life in asthma patients include education, distance to health facilities, socio-economic factors, age, employment status, gender, obesity, and anxiety/depression.
Co-Authors Affandhy , Adhwa’a Kaylla Affandhy, Adhwa’a Kaylla Apriani, Risa Dwi Azizah, Nabilla Faoziyyah Dzannuba, Fadya Laila Nurul Hikmah Putri, Mukarromah Dita Shadrina , Jahra Almas Shadrina, Jahra Almas Shella, Tasya Permata Sudarjat , Hadi Sudarjat, Hadi Sulistiawati Sulistiawati Zulqifli, Iqbal