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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Fentri, Ela
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Health Professions Medicine & Pharmacology

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The Effect Honey Has on SOD and Caspase9 Levels with Exposure to Cigarette Smoke in Wistar Rats Fentri, Ela; Isradji, Israhnanto; Trisnadi, Setyo
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 2 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i2.9102

Abstract

Cigarettes are a source of exogenous free radicals which disrupt the balance between free radicals and antioxidants in the body, causing oxidative stress. The aim of this study was to determine the effect of giving honey (Mel depuratum) on SOD and caspase-9 levels in Wistar rats exposed to cigarette smoke. This research used a laboratory experimental approach with a post-test only control group design. 24 Wistar rats were divided randomly into 4 groups then analysis tests were carried out using the One-Way ANOVA test and followed by the Post-Hoc LSD test. The results showed that the mean SOD levels in groups K1, K2, K3, K4 were 73.51 ± 1.68, 21.72 ± 2.23, 52.08 ± 2.03, and 73.51 ± 1.68. The results of the One Way Anova test showed a significant difference in SOD levels with a value of p = 0.000. The results of the LSD Post-Hoc Test showed that SOD levels between groups had significant differences in all groups (p=0.000). The IHK staining results showed that samples K1 and K4 were negative, while K2 showed strong positive and K3 was moderately positive.
Co-Authors Israhnanto Isradji Setyo Trisnadi