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Millisani, Hayla Iqda
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Health Professions Immunology & microbiology Medicine & Pharmacology

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Correlation between HbA1c levels and intrastent restenosis incidence in patients with diabetes mellitus after percutaneous coronary intervention at Dr. Saiful Anwar General Hospital Millisani, Hayla Iqda; Prasetya, Indra; Rohman, Mohammad Saifur
Heart Science Journal Vol. 5 No. 4 (2024): The Current Perspective About Cardiometabolic Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2024.005.04.10

Abstract

Background: Patients with chronic uncontrolled diabetes mellitus as indicated by HbA1c levels ≥ 6.5%, increase the risk of atherosclerosis, thereby increasing in-stent restenosis incidence during and after percutenous coronary intervention. Regular monitoring of HbA1c is crucial to reduce the incidence of in-stent restenosis.Objective: This study aims to ascertain the correlation between HbA1c levels and in-stent restenosis incidence in diabetes mellitus patients after percutenous coronary intervention at Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia.Methods/Design: Analytical observational study with a retrospective cohort study approach to determine the correlation between HbA1c levels and the incidence of in-stent restenosis in patients with diabetes mellitus after percutenous coronary intervention. The research sample was carried out by consecutive sampling in January 2021-December 2023.Results: This study has recruited 555 patients with coronary artery disease and diabetes mellitus. The average age of coronary heart disease patients with diabetes mellitus was 59 years. Patients with HbA1c levels ≥6.5 were more prone to experience in-stent restenosis 54 patients, while those with HbA1c levels <6.5 were more prone not to experience in-stent restenosis 388 patients, indicating a significant correlation between HbA1c and in-stent restenosis p=0.024. in-stent restenosis was most frequently observed in the LAD 44 patients, RCA 13 patients, LCx 10 patients, and LM 0 patient. The highest percentage of in-stent restenosis cases was over 70%, with 3VD lesions being the most common 55 patients. OAD therapy is most often given to coronary heart disease patients with diabetes mellitusConclusion: There is a correlation between HbA1c levels and the incidence of in-stent restenosis in diabetes mellitus patients after percutaneous coronary intervention, underscoring the necessity for routine blood glucose monitoring to prevent in-stent restenosis.
Increase Cardiovascular Event in Patient with Diabetes Mellitus Undergoing Percutaneous Coronary Intervention Millisani, Hayla Iqda; Prasetya, Indra; Rohman, Mohammad Saifur; Satrijo, Budi
Heart Science Journal Vol. 5 No. 3 (2024): The Science and Art of Revascularization in Acute Coronary Syndrome
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.03.5

Abstract

Diabetes mellitus (DM) associated with increase major risk factors of cardiovascular disease, such as peripheral arteriopathy, ischemic heart disease, or cerebrovascular accident. The Framingham study showed that patient with DM considerably increase coronary artery disease (CAD), particularly in old patient and women. Prevalence of DM is rising and cardiovascular mortality associated with DM is the main problem in the world. Additionally, there is a higher death rate among DM patients following a myocardial infarction with complications, such as stent thrombosis, instent restenosis, and no reflow phenomenon can worse overall long term prognosis with CAD. This review c onsiders the mechanism for diabetes mellitus in CAD patient, expecially patient with DM can increase risk of major complication in patient CAD undergoing percutaneous coronary intervention (PCI).
A 56 Year Old Male with Acute Stent Thrombosis During Percutaneous Coronary Intervention, How to Resolve This Problem? Millisani, Hayla Iqda; Rohman, Mohammad Saifur; Prasetya, Indra; Widito, Sasmojo
Heart Science Journal Vol. 4 No. 3 (2023): The Essensial Role of the Metabolic Syndrome in the Development of Cardiovascul
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2023.004.03.8

Abstract

Background: Acute stent thrombosis is the complete occlusion of a coronary artery of the previously implanted stent. This unusual complication occurs in percutaneous coronary intervention (PCI), development of myocardial ischemia, and poor prognosis for the patient. After PCI, acute stent thrombosiscan occur within 0-24 hours and cause the symptoms like acute coronary syndrome. Incidents of stent thrombosis are about 0.6% to 3.4% for Drug Eluting Stent (DES) implantation, depending on the lesion and patient factors. The etiology of acute stent thrombosis is multifactorial, and early detectioncan reduce the mortality rate.Case Illustration: A 56 yo male visited Rumah Sakit Saiful Anwar Malang with stable angina pectoris (Class III symptoms with medical therapy) planned for elective cardiac catheterization with routine medical treatment. During PCI, he complained the chest pain, and from cine angiography evaluation showed no flow at the diagonal branch because of the acute thrombosis. Then got thrombosuction and got a white thrombus. After the PCI procedure, he got fibrinolytic with streptokinase 1.5 million units for 60 minutes. He was transferred to CVCU for observation and discharged after five days.Conclusion: Acute stent thrombosis is a severe complication during and after PCI because it is related to high mortality. The mechanisms by which ST arises are complex and multifactorial and must be early detection.
Diagnosis and differentiation of pathological concentric left ventricular hypertrophy Millisani, Hayla Iqda; Karolina, Wella
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.6

Abstract

Identifying the diagnosis and differentiation of concentric left ventricular hypertrophy (LVH) can be crucial, as the various etiology ofter similar characteristics and morphology. Concentric left ventricular hypertrophy (LVH) is the term used to describe the enlargement of the left ventricle (LV), the increase in the mass and thickness of the LV wall which can occur in response to pressure overload. The most common etiology of concentric hypertrophy include the systemic hypertension, aortic stenosis and hypertrophic cardiomyopathy (associated with sarcomere mutations, infiltrative cardiac diseases, and storage disorders). Cardiac imaging is the predominant modality for visualizing and quantifying LVH in clinical practice and often collaborates with an established diagnosis. Echocardiography, the primary imaging modality, enables a thorough evaluation of left ventricular systolic and diastolic function. Cardiovascular magnetic resonance offers further benefits by correctly measuring left ventricular and right ventricular sizes and mass, as well as characterizing myocardial tissue properties. These measurements can provide valuable insights for making a final diagnosis.
A 56 Year Old Male with Acute Stent Thrombosis During Percutaneous Coronary Intervention, How to Resolve This Problem? Millisani, Hayla Iqda; Rohman, Mohammad Saifur; Prasetya, Indra; Widito, Sasmojo
Heart Science Journal Vol. 4 No. 3 (2023): The Essensial Role of the Metabolic Syndrome in the Development of Cardiovascul
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2023.004.03.8

Abstract

Background: Acute stent thrombosis is the complete occlusion of a coronary artery of the previously implanted stent. This unusual complication occurs in percutaneous coronary intervention (PCI), development of myocardial ischemia, and poor prognosis for the patient. After PCI, acute stent thrombosiscan occur within 0-24 hours and cause the symptoms like acute coronary syndrome. Incidents of stent thrombosis are about 0.6% to 3.4% for Drug Eluting Stent (DES) implantation, depending on the lesion and patient factors. The etiology of acute stent thrombosis is multifactorial, and early detectioncan reduce the mortality rate.Case Illustration: A 56 yo male visited Rumah Sakit Saiful Anwar Malang with stable angina pectoris (Class III symptoms with medical therapy) planned for elective cardiac catheterization with routine medical treatment. During PCI, he complained the chest pain, and from cine angiography evaluation showed no flow at the diagonal branch because of the acute thrombosis. Then got thrombosuction and got a white thrombus. After the PCI procedure, he got fibrinolytic with streptokinase 1.5 million units for 60 minutes. He was transferred to CVCU for observation and discharged after five days.Conclusion: Acute stent thrombosis is a severe complication during and after PCI because it is related to high mortality. The mechanisms by which ST arises are complex and multifactorial and must be early detection.
Successful Pregnancy in Uncorrected Tetralogy of Fallot with Right Aortic Arch: An Interdisciplinary Team Approach Millisani, Hayla Iqda; Putri, Valerinna Yogibuana Swastika
Heart Science Journal Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.01.8

Abstract

Background: Tetralogy of Fallot (ToF) is the most common cyanotic disorder, with a global prevalence of congenital heart disease nearly reaching 10%. The anomalies observed in individuals with ToF result from the anterior and cephalad displacement of the infundibular (outflow tract) component of the interventricular septum. ToF continues to be a significant contributor to maternal morbidity, mortality, and adverse outcomes in newborns with the condition.Case presentation: An 18-year-old woman in her 28th week of pregnancy was referred to our tertiary referral center, Saiful Anwar Hospital, diagnosed with uncorrected Tetralogy of Fallot (TOF), which had been noticed since she was 2 years old. At that time, her parents refused treatment. She became pregnant unexpectedly and was then directed to RSSA for further management.Conclusion: We present a successful case of pregnancy in a woman who has not undergone surgical repair for ToF. An interdisciplinary pregnancy heart team, including a cardiologist, obstetrician, anesthesiologist, midwives, and neonatologists at our tertiary hospital, developed a care plan based on an individualized assessment of the patient's comorbidities and ToF. The life expectancy of this pregnant woman and her baby is higher with a team approach. The choice of contraception and family planning should be part of the discussion and follow-up from the teenage years, allowing patients with ToF to control their fertility and make informed decisions about having children.
Co-Authors Indra Prasetya Karolina, Wella Mohammad Saifur Rohman Putri, Valerinna Yogibuana Swastika Satrijo, Budi Widito, Sasmojo