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All Journal Heart Science Journal
Bahar, Mokhamad Aswin
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Health Professions Immunology & microbiology Medicine & Pharmacology

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Inflammatory cascade unveiled: Exploring complications and therapeutic strategies for post-myocardial infarction inflammation (A literature review) Bahar, Mokhamad Aswin; Prasetya, Indra
Heart Science Journal Vol. 5 No. 3 (2024): The Science and Art of Revascularization in Acute Coronary Syndrome
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.03.4

Abstract

This comprehensive literature review delves into the inflammatory ramifications of myocardial infarction (MI), a global health concern with reported prevalences of 3.8% and 9.5% among those under and over 60 years, respectively. While the inflammatory cascade plays a crucial role in MI healing, its dysregulation can lead to complications. Recent advancements have unveiled intricate cellular and molecular pathways. The common post-MI complication of pericarditis poses diagnostic challenges due to symptom similarities with MI, requiring careful management, particularly in cases of Dressler’s syndrome. Promising therapeutic strategies, including anti-inflammatory approaches and ongoing drug development, are under exploration. Future research directions involve delving into unknown factors, identifying novel therapeutic targets, and validating emerging treatments in larger trials, emphasizing the imperative need for continued investigation into the inflammatory consequences of MI.
The role of GALNT and EGFR in vascular calcification: Study on pathophysiology and its implications in vascular therapy Bahar, Mokhamad Aswin; Rohman, Mohammad Saifur
Heart Science Journal Vol. 6 No. 2 (2025): The Complexity in the Management of Heart Rhythm Disorder
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.02.4

Abstract

Vascular calcification is a complex biomineralization process that occurs in arteries, primarily driven by the activity of vascular smooth muscle cells (VSMCs). This process involves the deposition of hydroxyapatite minerals in the arterial walls, particularly within the intima and media layers. Vascular calcification significantly increases the risk of cardiovascular diseases, including myocardial infarction, stroke, and heart failure. Understanding the role of GalNAc-transferase (GALNT) and the epidermal growth factor receptor (EGFR) in vascular calcification has advanced significantly. GALNT is involved in the regulation of glycosylation and affects various biochemical pathways, including insulin signaling and lipid metabolism. Variations in GALNT expression can influence the risk of vascular calcification, highlighting the crucial role of glycosylation in the pathogenesis of vascular calcification. On the other hand, EGFR contributes to vascular calcification by modulating the activity of tissue-nonspecific alkaline phosphatase (TNAP) and the formation of calcifying extracellular vesicles, as well as through the proliferation and migration of VSMCs. A deeper understanding of the roles of GALNT and EGFR provides new insights into the pathophysiological mechanisms of vascular calcification and opens up opportunities for the development of more effective therapies. This review aims to enhance scientific knowledge and provide a foundation for further research and the development of more targeted and personalized therapies in the prevention and treatment of vascular calcification.
Co-Authors Indra Prasetya Mohammad Saifur Rohman