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All Journal Majalah Patologi Indonesia ABSYARA: Jurnal Pengabdian Pada Masyarakat
Alamanda, Intan Nefia
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Agriculture, Biological Sciences & Forestry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Library & Information Science Mathematics Public Health Other

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Immunohistochemistry Expression Gata3 Based on Subtypes of Ovarian Carcinoma at Haji Adam Malik General Hospital Medan 2019-2021 Alamanda, Intan Nefia; Betty, Betty; Delyuzar, Delyuzar; Laksmi, Lidya Imelda; Chrestela, Jessy; Soekimin, Soekimin
Majalah Patologi Indonesia Vol. 33 No. 3, September 2024
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.604

Abstract

Background Ovarian carcinoma is a cancer with high mortality in women and although comprehensive management with surgery and chemotherapy at an advanced stage, the resistance rate is still low. GATA3 contributes to the progression of malignancy and its expression is one of the predictors in some malignancies, but the results are mixed in ovarian carcinoma. High GATA3 expression is associated with the aggressiveness of tumor growth and poor prognosis of ovarian carcinoma.   Methods This research is an cross-sectional descriptive-analytical study with 33 histological specimens diagnosed with ovarian carcinoma from medical records/archives at H. Adam Malik Hospital Medan. Each sample specimen was stain with GATA3, and several various histopathological subtypes of ovarian carcinoma.   Results From a total of 33 samples, 14 samples were serous carcinoma, 6 samples were mucinous carcinoma, 7 samples were endometrioid carcinoma, and 6 samples were clear cell carcinoma. GATA3 was expressed in 42.5% of serous carcinoma. Positive expression of GATA3 is mostly found in advanced ovarian carcinoma, older age, and histopathological type of serous carcinoma.    Conclusion Immunohistochemistry GATA3 expression was expressed in 42.4% of serous carcinoma, 21.2% in endometrioid carcinoma, 18.2% in clear cell carcinoma, and 18.2% in mucinous carcinoma.   Keywords: ovarian carcinoma, GATA3, immunohistochemistry
Correlation between GATA3 Immunohitsochemistry and TP53 on some Ovarium Carcinoma Histopathology Subtype Alamanda, Intan Nefia; Betty, Betty; Delyuzar, Delyuzar; Chrestella, Jessy; Soekimin, Soekimin
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.665

Abstract

Background Ovarian carcinoma is a cancer with high mortality in women, although comprehensive treatment with surgery and chemotherapy is at an advanced stage, survival rates are still low. GATA3 and p53 are predictors of some malignancies, but results vary in ovarian carcinoma. Objective To examine correlation between immunohistochemical expression of GATA3 and p53 in patients with ovarian carcinoma with various histopathological subtypes. Materials and Methods Cross sectional design is the method of this study conducted on slides of 28 ovarian carcinoma patients in several subtypes of hitopathology. Each slide was stained with hematoxylin and eosin (H&E) to assesses hitopathological subtypes and stained with GATA3 and p53 antibodies. Expression GATA3 was assessed using H-score and p53 quick score. A logistic regression assay (p<0.005) was used to assessed the association of GATA3 and TP53 immunohistochemical expression in several histopathological subtypes of ovarian carcinoma. Statistical analysis between GATA3 and p53 was performed using the eta correlation test is used because the data is nominal-ordinal. Results Among 28 specimens in patients with ovarian carcinoma, Cases was most prevalent in the age group >50-60 years (age range 58 years), history of nullipara parity, and most in the group of stage III ovarian malignancy. Positive immunohistochemical p53 expression is more prevalent in serous carcinoma. Positive GATA3 immunohistochemical expression is more prevalent in serous carcinoma. Conclusion There is no significant relationship. Immunohistochemical expression of GATA3 and TP53 in some histopathological subtypes of ovarian carcinoma. However, immunohistochemical expression of GATA3 high p53 positive tends to be found in high-grade serous carcinoma. Keywodrs: GATA3, p53, karsinoma ovarium, Serous carcinoma, Mucinous carcinoma, Endometrioid carcinoma, Clear cell carcinoma.
CFD Sehat: Skrining tekanan darah, gula darah, dan edukasi PTM di Selong Faradila, Faradila; Rahman, Arief; Harahap, Andi Nizam; Angga, Ero Ari; Alamanda, Intan Nefia; Ramadlan, Lalu; Amaani, Raania; Haritani, Hartini
ABSYARA: Jurnal Pengabdian Pada Masayarakat Vol 6 No 2 (2025): ABSYARA: Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/ab.v6i2.33347

Abstract

Car Free Day (CFD) events offer a practical venue for health promotion and early detection of noncommunicable diseases (NCDs). This community service program aimed to conduct blood pressure and random blood glucose screening while delivering brief NCD prevention education to the public at CFD Taman Rinjani, Selong. The activity was implemented on 30 November 2025 and involved 80 participants. The program included on-site measurements of blood pressure and random blood glucose, descriptive grouping of results by age and sex, and short counseling on NCD prevention and recommended follow-up. The findings indicated an age-related increase in mean systolic blood pressure, with the highest proportion of hypertension observed among older adults. Across younger and mid-adult groups, hypertension tended to be more frequent in men than in women. Elevated random blood glucose was uncommon overall but appeared mainly among women and was more noticeable in the older-age group. In summary, integrating screening and education in a public setting can help identify at-risk groups and encourage regular check-ups. Regularly scheduled CFD-based programs supported by selective referral pathways and strengthened lifestyle education may contribute to NCD risk reduction.
Edukasi deteksi dini kanker payudara dan serviks berbasis komunitas pada Muslimat NWDI Angga, Ero Ari; Rahman, Arief; Harahap, Andi Nizam; Alamanda, Intan Nefia; Ramadlan, Lalu; Amaani, Raani; Faradila, Faradila; Haritani, Hartini
ABSYARA: Jurnal Pengabdian Pada Masayarakat Vol 6 No 2 (2025): ABSYARA: Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/ab.v6i2.33561

Abstract

Cancer education is an essential effort to improve public awareness and understanding, particularly among women, regarding the early detection of breast and cervical cancer. This community service activity aimed to provide education on cancer awareness, the importance of early detection, and the adoption of healthy lifestyles among Muslimat NWDI in East Lombok, West Nusa Tenggara. The activity was conducted through health education sessions combined with interactive discussions and an evaluation of participants’ understanding using a simple assessment instrument. The educational materials covered an introduction to breast and cervical cancer, breast self-examination (BSE), the importance of Pap smear screening, and lifestyle-related factors associated with cancer prevention. The results indicated that most participants demonstrated good to very good levels of understanding of the presented materials. Higher levels of understanding were observed among pre-elderly participants and those with a higher educational background. However, psychosocial barriers such as feelings of shame, fear, and cultural stigma related to reproductive health examinations were still identified. This socialization activity contributed positively to increasing participants’ awareness of the importance of early cancer detection. Nevertheless, continuous assistance and improved access to health services are needed to ensure the practical implementation of early detection behaviors within the community
Co-Authors Amaani, Raani Amaani, Raania Angga, Ero Ari Arief Rahman betty betty Chrestela, Jessy Chrestella, Jessy Delyuzar, Delyuzar Faradila, Faradila Harahap, Andi Nizam Hartini Haritani Laksmi, Lidya Imelda Ramadlan, Lalu Soekimin Soekimin, Soekimin