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All Journal JURNAL PENGABDIAN KEPADA MASYARAKAT Universa Medicina JURNAL IBNU SINA BIOMEDIKA Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Abdimas Universal JURNAL ILMIAH MAKSITEK Bioscientia Medicina : Journal of Biomedicine and Translational Research
Delyuzar, Delyuzar
Universitas Sumatera Utara
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PERBANDINGAN ANTARA NEOPLASMA JINAK DAN GANAS PADA PAYUDARA BERDASARKAN PEMERIKSAAN FISIK DIAGNOSTIK DAN BIOPSI ASPIRASI JARUM HALUS Chairani, Rizki; Delyuzar, Delyuzar
JURNAL IBNU SINA BIOMEDIKA Vol 1, No 2 (2017)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.058 KB) | DOI: 10.30596/isb.v1i2.1655

Abstract

Latar Belakang. Tumor ganas (kanker) payudara merupakan keganasan pada wanita yang paling umum terjadi hampir semua negara dengan kejadian yang disesuaikan menurut umur tertinggi di negara maju sebanyak 73% dan termasuk 23% dari semua kanker. Pada masyarakat khususnya pada wanita kanker payudara merupakan kanker kedua paling banyak setelah kanker serviks. Tumor ganas (kanker) payudara umumnya menyerang wanita yang telah berumur >40 tahun. Namun demikian, wanita dengan usia muda bisa terserang kanker ini, tetapi pada usia muda lebih sering terkena tumor jinak payudara. Pada masyarakat khususnya pada wanita. Tujuan. Penelitian ini bertujuan untuk mengetahui perbandingan antara neoplasma jinak dan ganas pada payudara berdasarkan pemeriksaan fisik diagnostik dan pemeriksaan biopsi aspirasi jarum halus. Metode. Penelitian ini bersifat deskriptif analitik dengan desain cross-sectional. Sampel adalah pasien di RSUD Deli Serdang, yang berjumlah 25 orang. Teknik pegambilan sampel dengan metode total sampling. Analisis penelitian menggunakan uji fisher exact test. Hasil. Distribusi frekuensi yang terbanyak berdasarkan pekerjaan 21 orang (84%) dan terendah berdasarkan usia 14 orang (82,4%) dari faktor fisiko kanker payudara. Kesimpulan. Didapatkan bahwa tumor jinak dan ganas paling banyak terjadi pada ibu rumah tangga.Kata kunci: pemeriksaan fisik payudara, faktor risiko kanker, pemeriksaan biopsi aspirasi jarum halus
PENGARUH PEMBERIAN EKSTRAK BUAH PARE (MOMORDICA CHARANTIA) TERHADAP GAMBARAN HISTOPATOLOGI ORGAN TRAKEA PADA TIKUS WISTAR YANG DIINDUKSI OBAT NYAMUK BAKAR Utami, Tania Mulia; Lubis, Humairah Medina Liza; Delyuzar, Delyuzar; Sutysna, Hendra
JURNAL IBNU SINA BIOMEDIKA Vol 2, No 1 (2018)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (564.5 KB) | DOI: 10.30596/isb.v2i1.1907

Abstract

Background: indonesia is a tropical country and has two seasons, there are summer and rainy season. This condition will  increase the population of mosquito especially in transition period. The producer of insect-repellent use this opportunity to make mospuito coil. In fact, mosquito coil is dangerous for the healthy of trachea. There are many herbs has been investigated, including pare, because it contains antioxidant. Objective: This experiment is about the effect of pare’s extract (Momordica charantia) in  histopathology of trachea in wistar mouse which is induced by mosquito coil. Method : laboratoric experiment with posttest only with control group design. Mouses divide into 4 groups and will be treat for 30 days. After that, the extract will be given in250mg/bw and500mg/bw. This experiment will examine the histopathology of trachea with HE and  light microscope. The data will be analyzed with Kruskal-wallis post Hoc Mann-Whitney. Result: there are significant diffrentiation  in degeneration, metaplasia, necrosis, and mucose thickening score in experiment and control group. Giving 250mg/bw and 500mg/bw of pare’s extract show improvement in trachea tissue. Conclusion: giving mosquito coil can induce the damage of trachea tissue with degeneration, metaplasia, necrosis and mucose thickening process. Giving pare’s extract as antioxidant show the improvement of trachea histopathologyKeywords: pare’s extract, mosquito coil, trachea histopathology, flavonoid.
Hubungan antara Ekspresi CD-10 dan Grading Histopatologi Karsinoma Payudara Invasif Fitri Dewi Ismida; Soekimin; Delyuzar
Majalah Patologi Indonesia Vol 28 No 2 (2019): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (387.905 KB)

Abstract

Latar belakangKarsinoma payudara invasif merupakan suatu keganasan epitelial payudara yang ditandai oleh invasi sel-selepitel ke dalam stroma. Secara global, insidensi karsinoma payudara invasif menduduki peringkat tertinggi danterus meningkat dari tahun ke tahun. Pada jaringan payudara normal, ekspresi CD-10 terlokalisir pada sel-selmioepitel dan tidak teridentifikasi pada stroma. Demikian juga, pada ductal carcinoma in situ (DCIS), CD-10tidak terekspresi pada stroma. Namun pada karsinoma payudara invasif CD-10 akan terekspresi pada stroma.CD-10 merupakan suatu cell-surface zinc-dependent metalloproteinase yang sering direkomendasikan sebagaimarker leukemia limfoblastik. Beberapa penelitian telah dilakukan untuk menilai hubungan antara ekspresi CD10 dan grading histopatologi karsinoma payudara invasif, namun sampai kini hasilnya masih kontroversi.Tujuan penelitian ini untuk menganalisis hubungan antara ekspresi imunohistokimia CD-10 dan gradinghistopatologi karsinoma payudara invasif.MetodePenelitian ini merupakan penelitian deskriptif analitik dengan pendekatan cross sectional. Sampel penelitianadalah blok parafin, berasal dari jaringan payudara yang didiagnosis secara histopatologi sebagai karsinomapayudara invasif. Sampel dipulas dengan teknik immunohistokimia menggunakan CD-10; dan kemudianekspresi CD-10 dianalisis dengan uji Kruskal-Wallis.HasilBerdasarkan analisa statistik Kruskal-Wallis terhadap 60 sampel kasus karsinoma payudara invasif mengujihubungan ekspresi imunohistokimia CD-10 dengan grading histopatologi karsinoma payudara invasif, diperolehp-value=0,0001 (p<0,05).KesimpulanEkspres
Hubungan Jumlah Sel Mast dengan Tampilan Ekspresi Vascular Endothelial Growth Factor (VEGF) pada Cutaneous Squamous Cell Carcinoma Edi Kerina Sembiring,; Delyuzar; Soekimin
Majalah Patologi Indonesia Vol 28 No 3 (2019): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (400.943 KB)

Abstract

BackgroundThe most common non-melanocytic skin cancers are basalioma and squamous cell carcinoma. Squamouscell carcinoma is a malignancy of squamous epithelium. Mast cells stimulate neovascularization andangiogenesis in multiple tumors. One of the main factors of angiogenesis in squamous cell carcinoma isthe Vascular Endothelial Growth Factor (VEGF). The aim of this study is to investigate the associationbetween number of mast cells with the expression of VEGF of cutaneous squamous cell carcinoma.MethodsThis is an analytical descriptive study with cross sectional approach. The sample of this study are paraffinblocks of skin tissue which diagnose histopathologically as squamous cell carcinoma. Then the sampleswill be stained with immunohistochemistry CD117 (Novocastra®) to count the number of mast cells andVEGF (Dako®) to see angiogenesis. Their expression will be analyzed with Fisher’s Exact Test statisticalanalysis to investigate the association between number of mast cells with expression of VEGF ofcutaneous squamous cell carcinoma.ResultsThe number of mast cells ≥15 cells were 7 cases (23.3%). Expressed VEGF positive expression in 30cases (100%). Suitability test Fischer's Exact Test has value not significant (p> 0.05).ConclusionThere is no conformance relationship between the number of mast cells with VEGF expression of p-value.
Hubungan Ekspresi Imunohistokimia Cyclooxygenase-2 (COX-2) dengan Derajat Histopatologi Meningioma Indri Mahrani; Delyuzar; Joko S. Lukito
Majalah Patologi Indonesia Vol 28 No 3 (2019): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

ABSTRAKLatar belakangMeningioma adalah neoplasma intrakranial primer yang umum pada orang dewasa, berasal dari sel arachnoid(meningothelial). Gambaran histologis meningioma adalah prediktor penting untuk perilaku tumor.Cyclooxygenase-2 (COX-2) adalah enzim yang diekspresikan dalam berbagai jenis tumor dan diketahui terkaitdengan perilaku ganas tumor. Tujuan dari penelitian ini untuk mengevaluasi ekspresi imunohistokimia COX-2pada meningioma dan mencari hubungannya dengan derajat histopatologik.MetodePenelitian Ini merupakan penelitian deskriptif analitik dengan pendekatan cross sectional. Sampel penelitian iniadalah 22 blok parafin dengan diagnosis meningioma yang ditentukan derajat histopatologiknya dan diwarnaidengan imunohistokimia COX-2. Penilaian dilihat berdasarkan intensitas warna dan persentase sel yangterwarnai pada sitoplasma. Intensitas warna: 1 (lemah), 2 (sedang), 3 (kuat). Persentasi sel yang positif=0(0%), 1 (<10%), 2 (10-50%), 3 (>50%). Penilaian merupakan penjumlahan intensitas warna dan persentasipositif (>4), negatif (<4).HasilDuapuluh dua kasus meningioma: usia rerata=41 tahun, perempuan=90,9%, meningothelial=22,7%, derajatI=77,3%). Ekspresinya. COX-2: negatif: 17 kasus (77,3%) semuanya merupakan derajat I. COX-2 positif: 5kasus (22,7%) (4 kasus derajat II, 1 kasus derajat III). Ekspresi COX-2 pada meningioma berhubungan denganderajat histopatologik berdasarkan WHO (p=0,001).KesimpulanPada penelitian ini terdapat hubungan antara ekspresi imunohistokimia COX-2 dengan derajat histopatologik, dimana COX-2 lebih terekspresi pada derajat II dan III.
Hubungan Ekspresi CD117 dan Epidermal Growth Factor Receptor (EGFR) terhadap Grading Histopatologi Adenoid Cystic Carcinoma pada Kelenjar Liur Ren Astrid Allail Siregar; T. Ibnu Alferraly; Delyuzar
Majalah Patologi Indonesia Vol 29 No 1 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.861 KB) | DOI: 10.55816/mpi.v29i1.402

Abstract

BackgroundTend to have adenoid cystic carcinoma (AdCC) is one of malignant epithelial tumor of the salivary gland poor prognosis, localrecurrence and metastases. Histopathological grading system according Weert, et al. observed from presence or absence solidcomponent of AdCC. CD117 is a transmembrane tyrosine kinase receptor usually strong expression in AdCC. EGFR belongs to theErbB family of receptor tyrosine kinases associated with cell proliferation, angiogenesis and metastases. Patients with advanceddisease may benefit from targeted therapy besides conventional management. Expression of CD117 and EGFR may give proposaltherapy through difference histology pattern of AdCC based on histopathological grading.MethodsThis is an analytical descriptive study with cross sectional approach. Formalin-fixed paraffin-embedded sections from 35 adenoidcystic carcinomas were obtained for histopathological grading and for immunostained of CD117 and EGFR using monoclonalantibodies. The staining intensity and percentage of cells with membranous and cytoplasmic of CD117 and EGFR expression werescored and then grouped according to the parameters of the Allred scoring system.ResultsChi-square test between CD117, EGFR expression and histopathological grading of AdCC showed no sigficant differences.Besides, McNemar test between CD117 and EGFR expression and histopathological grading AdCC showed significant differences,p-value=0.03 (p<0.05).ConclusionsCD117 and EGFR could be used to detected salivary gland AdCC
Identifikasi Polimorfisme Gen CYP1A1 pada Karsinoma Sel Skuamosa dan Adenokarsinoma Serviks Hilda Fitriyani; Delyuzar; Hidayat
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.482 KB) | DOI: 10.55816/mpi.v29i2.410

Abstract

BackgroundCervical cancer is the third most common cancer in women with risk factor of smoking, high parity, long term use of oralcontaception that are associated with chemical carcinogenesis. Chemical carcinogenesis require biotransfor-mation of lipophilicsubstrates to hydrophilic metabolites, therefore facilitating their secretion from the human body. Cytochrome P450 (CYP) is one ofgenes that have important role in this process. Benzo[α]pyrene and estrogen have a common biotransformation process which ismetabolized by CYP, particularly CYP1A1. The objectives to identify the frequency and distribution of CYP1A1 gene polymorphismin squamous cell carcinoma and adenocarcinoma of the cervix.MethodsThis is an analytical descriptive study with cross sectional approach. CYP1A1 gene polymorphism (3801T/C or Ile462Val) wasanalyzed using PCR-RFLP method followed by gel electrophoresis.ResultsCYP1A1 gene polymorphisms (3801TC) in squamous cell carcinoma were 50% heterozygote T/C, 36% wild-types T/T and 14%homozygote C/C. CYP1A1 gene polymorphisms (3801TC) in adenocarcinoma were 60% heterozygote T/C and 40% wild-types T/T.CYP1A1 gene polymorphisms (Ile462Val) in squamous cell carcinoma were 97.2% heterozygote Ile/Val, and 2.8% homozygoteVal/Val. CYP1A1 gene polymorphisms (Ile462Val) in adenocarcinoma were 100% heterozygote Ile/ValConclusionThe most common type of CYP1A1 gene polymorphism (3801TC and Ile462Val) in squamous cell carcinoma and adenocarcinomaof the cervix were heterozygote.
Analisis Gambaran Morfologi Limfadenitis Tuberkulosis Menggunakan Metode Biopsi Aspirasi Jarum Halus dan Polymerase Chain Reaction Dedy Suryadi; Delyuzar; Soekimin
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.968 KB) | DOI: 10.55816/mpi.v29i2.419

Abstract

BackgroundIndonesia is the 2nd largest of tuberculous (TB) cases in the world. Therefore, TB must be controlled by increasing the capacity anddeveloping universal access needed for TB diagnose accurately and quickly. Progression in controlling TB and decreasing theconsequence can be accelerated through early detection and promt treatment. This study used PCR test as gold standard, albeitthe high cost. Thus, quick, accurate and low cost diagnostic method is needed. In this case morphologic features requirementinclude the existence of epithelioid and necrosis in FNAB smears. Objective was to analyze morphologic features of tuberculosislymphadenitis using FNAB and PCR methods.MethodsThis study is a cross sectional analysis. N samples are all kind of lymphadenitis tuberculosis. Morphologic features in FNABcytology must be confirmed using PCR test and performing chi-square test respectively.ResultsEpitheloid and necrosis features of TB lymphadenitis on FNAB showed 100% positive on PCR methods. This study divided intothree groups. Statistic analyses between group I and II, group II and III showed in significant differences (p=0.074); while betweengroup I and III showed significant differences (p<0.05).ConclusionsPCR method could confirmed morphologic features (epitheloid and necrosis) of TB lymphadenitis
The Presence of Helicobacter pylori in cases of Chronic Tonsillitis in Medan Harahap, Rini Syahrani; Delyuzar; Jessy Chrestella
Sumatera Medical Journal Vol. 3 No. 1 (2020): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v3i1.2044

Abstract

Background: Helicobacter pylori is a well known pathogen which is recognized as the most frequent infection of individuals. Helicobacter pylori plays important role in the etiology og gastritis, gastric and duodenal ulcers. We investigated the presence of Helicobacter pylori as an extragastric reservoir in the tonsilectomy specimens. Aim: To determine the presence of Helicobacter pylori in cases of chronic tonsillitis in tonsilectomy specimens. Methods: This is a descriptive study with cross sectional which the sample will be obtained using consecutive sampling method. We collect 43 cases with chronic tonsilitis were examined in tonsillectomy specimens for which available tissue for routin staining could be retrieved were histopathology chronic tonsillitis. The colonization of the helicobacter pylori have been evaluated with hematoxylin & Eosin and Giemsa stains under the light microscope. Results: With H&E staining, Helicobacter pylori has been detected in 23 cases (53,48%) of the tonsil-lectomy specimens in total. No colonization has been observed in the remaining 20 cases (46,51%). With giemsa staining Helicobacter pylori has been detected in 29 cases (67,74%) of the tonsillectomy specimens in total. No colonization has been observed in the remaining 14 cases (32,55%). Keywords: Helicobacter pylori, Chronic Tonsillitis, H&E, Giemsa.
Nilai Numerik Sitomorfometri Keliling dan Densitas Inti pada Fibroadenoma, Karsinoma Duktus dan Karsinoma Lobular Payudara fitriani Lumongga; Muhammad Nadjib D Lubis; Delyuzar
Majalah Patologi Indonesia Vol 19 No 1 (2010): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.998 KB)

Abstract

ABSTRAKLatar BelakangPemeriksaan sitologi biopsi aspirasi jarum halus penting dalam diagnosa preoperatif lesi payudara. Sampai saatini interpretasi sediaan sitologi sering bersifat subjektif. Untuk mendapatkan diagnosa yang lebih objektif,diperlukan aplikasi tambahan dengan menggunakan komputer melalui images analysis. Morfometri yangdilakukan dengan komputerisasi dan analisa gambar dapat digunakan untuk menghitung ukuran sel, sepertikeliling inti (perimeter) dan densitas inti.TujuanTujuan studi ini membandingkan ukuran perimeter dan densitas inti antara fibroadenoma, karsinoma duktus dankarsinoma lobular payudara dengan menggunakan image analysis.Bahan dan CaraPenelitian menggunakan studi potong lintang dengan jumlah sampel 10 pada setiap kelompok. Sediaan hasilbiopsi aspirasi diwarnai Diff-Quik dan dilakukan pengukuran morfometri dengan pewarnaan Fuelgen. Penilaianmorfometri inti menggunakan MCID Analysis software pada 50 sel tiap slide dan dinyatakan dengan angka yangdapat dipindahkan ke dalam bentuk histogram. Perbedaan beberapa variabel diuji statistik dengan tesBonferroniHasilRata-rata keliling inti fibroadenoma mammae: 0,513 µm, karsinoma duktus : 0,887 µm, karsinoma lobular: 0,634µm. Rata-rata densitas inti fibroadenoma 0,45006: Relative optical density (ROD) dan karsinoma duktus: ROD.0,5338KesimpulanPada hasil penelitian terdapat perbedaan rata-rata keliling inti pada lesi fibroadenoma, karsinoma duktus dankarsinoma lobular payudara serta terdapat perbedaan densitas inti lesi payudara fibroadenoma dan karsinomaduktus dengan menggunakan pewarnaan Fuelgen.
Co-Authors Ahyar Riza Alamanda, Intan Nefia Alferraly, T. Ibnu betty betty Chairani, Rizki Chrestela, Jessy Chrestella, Jessy CINDY CLARA AWE Dedy Suryadi Diana Rizki DITA ANNISA DIARA NASUTION Dr. Endang Sjamsudin, drg, Sp.BMMF, Subsp.TMF-TMJ[K] Edi Kerina Sembiring, Edy Fachrial Eka Airlangga Emita Sabri Feby Yanti Harahap Fiandani, Fatma Fitri Dewi Ismida fitriani Lumongga Harahap, Rini Syahrani HENDRA SUTYSNA Hidayat Hidayat Hidayat Hilda Fitriyani Humairah Medina Liza Lubis Ibnu Alferally Indri Mahrani Indriani Saragih, Septina intan nefia alamanda Intan, T. Kemala Jessy Chrestella Joko S. Lukito Kharismawaty, Dina Laksmi, Lidya Imelda Lidya Imelda Laksmi Lita Feriyawati Lokot Donna Lubis Lubis, Fahrurrozi Lubis, Nenni Dwi Aprianti Lukito, Joko S. M. Nadjib D. Lubis Mariedina, Causa Trisna Muhammad Nadjib D Lubis Muhammad Ramli Nadjib Dahlan Lubis Nasution, Annio Indah Lestari Nurcahaya Sinaga Nurlela Nurlela P. Poida B. Gurning Ren Astrid Allail Siregar Reza Aditya Digambiro Rita Juliana Pohan Roza Rita S Lukito, Joko Sihotang, Marisi Cintya Debby sinambela, Roy Herbon Soekimin Soekimin Soekimin Soekimin Soekimin Soekimin Soekimin, Soekimin Sri Amelia, Sri Sufitni Sunarti Sunarti Syafruddin Ilyas T Kemala Intan T. Ibnu Alferally T. Ibnu Alferally T. Ibnu Alferraly tengku ibnu alferraly Tri Widyawati Urip Harahap Utami, Tania Mulia