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All Journal Majalah Patologi Indonesia International Journal of Nasopharyngeal Carcinoma Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Chrestella, Jessy
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Humanities Health Professions Medicine & Pharmacology Public Health

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CORRELATION OF TNF-Α EXPRESSION TO CLINICAL STADIUM IN NASOPHARYNGEAL CARCINOMA Susilo, Riko; Farhat; Asnir, Rizalina A; Yudhistira, Ashri; Daulay, Elvita Rahmi; Chrestella, Jessy
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA (IJNPC) Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3503

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in Indonesia with over 13.000 new cases reported yearly, especially in the male. The TNF-? serum is reported as a new biomarker to predict bone invasion, post-therapy distant metastasis, and poor life sustainability in NPC. Objective: To identify the expression of TNF-? in regards to the clinical stage of NPC. Material and methods: This is an analytic study with 126 NPC samples of patients in Haji Adam Malik General Hospital. Results: NPC mostly found in age group 41-60 years (57.1%), male (71.4%),non-keratinizing SCC (79.4%), and stage IV group (54.8%). In immunohistochemistry evaluation, most of TNF-? overexpressed in non-keratinizing SCC(68.0%), T3-T4 (50.8%), N2-N3 (62.7%) and clinical stage III-IV (69.9%). Spearman's test for categorical correlation yield a p-value of <0,001. Conclusion: There is a significant correlation between TNF-? expression and the stage of NPC.
Correlation between Reactive Stromal Expression and Histochemical Trichrome Masson Staining with Histopathological Grading in Prostate Adenocarcinoma at Adam Malik Haji Center General Hospital Medan Basrul, Mohd. Yuwanda; Laksmi, Lidya Imelda; Mariedina, Causa Trisna; Lubis, M. Nadjib Dahlan; Intan, T. Kemala; Chrestella, Jessy
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.584

Abstract

Background Adenocarcinoma of the prostate is an invasive carcinoma, composed of neoplastic prostatic epithelial cells with differentiation and secretion arranged in various histomorphological patterns.Quantitative analysis of the elements that make up the stroma in casesprostate adenocarcinomahas been linked to prognostic factors and the Gleason score, which correlates with progression and metastasis, and may contribute to new prognostic feature approaches.   Method Descriptive analytic study with 33 paraffin block samples diagnosed as prostate adenocarcinoma at Haji Adam Malik General Hospital Medan.Assessment is done forsee the relationship between reactive stromal expression using Trichrome Masson and histopathological grading gleason score then determine the scoring score for the stroma around the prostate gland adenocarcinoma lesion stained blue with trichrome masson, a positive score of one (+): if 0-15% stroma is stained blue, positive two (++): if >15%-<50% stroma is stained and triple positive (+++): if >50% stroma is stained blue. The histopathological grading was categorized into grade I (well differentiated: Gleason score ≤6), grade II (moderately differentiated: Gleason score 7 (3+4)), and grade III (poorly differentiated: Gleason score 7 (4+3) and 8 -10).   Results: Reactive stromal expression the most found was positive three (+++) (69.7%) and the most common histopathological grading was grade III (69.7%). There was a significant correlation between reactive stromal expression and histopathological grading in prostate adenocarcinoma (p-value=0.044), namely the worse the cell differentiation, the higher the positive score of reactive stromal expression.   Conclusion Assessment of reactive stromal expression associated with histopathological grading can be used as an indication of prognosis in patients with prostate adenocarcinoma.
Hubungan Ekspresi Transforming Growth Factor-β1, Fibroblast Activated Protein, pola Tumor-Associated Collagen Signature dan derajat Tumor-Infiltrating Lymphocytes terhadap Grading International Society of Urological Pathology pada Clear Cell Renal Cell Ca Kharismawaty, Dina; Delyuzar, Delyuzar; Betty, Betty; S Lukito, Joko; Chrestella, Jessy
Majalah Patologi Indonesia Vol. 32 No. 1 (2023): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i1.568

Abstract

BackgroundClear cell renal cell carcinoma (ccRCC) is a very aggressive cancer and is often diagnosed at an advanced stage. The stromal component around the tumor is thought to have contributed greatly to these findings.MethodsAnalytical study with cross sectional design on 23 histological specimens diagnosed by ccRCC based on data from medical records/pathology archives in 2012-2021. Each specimen was stained with hematoxylin and eosin, TGF-β and FAP immunohistochemistry and Masson's trichrome. Fisher's exact test (p<0.05) was used to assess the association between the expressions of all variables with the ISUP grading.ResultsMost cases were high grade ccRCC (87%) samples, of which 73.9% samples expressed strong TGF-β, 82.7% samples expressed positive intratumoral FAP, 78.3% samples expressed positive stromal FAP, 47.8% showed a TACS-3-pattern, 56.5% of samples with positive stromal TILs and 47.8% of samples with negative intratumoral TILs. There was no significant association between all of these variables and the ISUP grading of the ccRCC (p<0.05).ConclusionExpression of TGF-β1, intratumoral and stromal FAP, TACS pattern and the degree of intratumoral and stromal TILs were not significantly associated with ISUP grading in ccRCC.
PEMERIKSAAN IMUNOHISTOKIMIA CLAUDIN-4 PADA PREPARAT CELL BLOCK CAIRAN EFUSI PLEURA BERDASARKAN KATEGORI DIAGNOSTIK THE INTERNATIONAL SYSTEM FOR REPORTING SEROUS FLUID CYTOPATHOLOGY: IMMUNOHISTOCHEMICAL EXAMINATION OF CLAUDIN-4 ON CELL BLOCK PREPARATIONS OF PLEURAL EFFUSION FLUIDS BASED ON DIAGNOSTIC CATEGORIES OF THE INTERNATIONAL SYSTEM FOR REPORTING SEROUS FLUID CYTOPATHOLOGY Kuncara, Dede Bisma; Mariedina, Causa Trisna; Betty; Lukito, Joko S; Chrestella, Jessy
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 24 No. 2 (2025): Juli 2025
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v24i2.746

Abstract

Efusi pleura mencerminkan kondisi patologis seperti gangguan paru, pleura, sistemik, hingga keganasan. Pemeriksaan sitologi dan imunohistokimia (IHK) cairan efusi pleura bertujuan untuk menilai keterlibatan pleura terhadap metastasis dan meningkatkan ketepatan diagnosis serta penilaian prognostik. Claudin-4, protein transmembran, diketahui terekspresi secara konsisten pada adenokarsinoma metastatik. Penelitian ini bertujuan mengetahui ekspresi IHK Claudin-4 pada sediaan cell block cairan efusi pleura berdasarkan The International System for Reporting Serous Fluid Cytopathology. Penelitian ini merupakan studi deskriptif analitik dengan pendekatan potong lintang terhadap 49 sampel cairan efusi pleura yang diproses menjadi cell block, kemudian dilakukan pewarnaan Hematoksilin-Eosin dan IHK Claudin-4 di RS Pendidikan Prof. dr. Chairuddin Panusunan Lubis USU. Hasil menunjukkan kelompok usia terbanyak 41–50 tahun (32,65%), laki-laki lebih banyak (55,10%), cairan transudat (57,14%), dan volume efusi 11–20 mL (30,61%). Diagnosis sitologi terbanyak adalah kategori NFM (85,72%) dan MAL (14,28%). Ekspresi Claudin-4 positif ditemukan pada seluruh sampel kategori MAL (7/7) dan negatif pada kategori NFM (42/42). Simpulan: Ekspresi Claudin-4 positif pada semua kasus MAL dan negatif pada NFM, menunjukkan potensi Claudin-4 sebagai penanda diagnostik untuk efusi pleura maligna.
Comparison of Examination Results of Cytocentrifuge Cytology and Cell Block Methods on Pleural Fluid Confirmed with Calretinin Immunohistochemistry as Mesothelial Cell Marker Fitri Desimilani, Fitri Desimilani; Mariedina, Causa Trisna; Betty, Betty; Soekimin, Soekimin; Chrestella, Jessy
Majalah Patologi Indonesia Vol. 34 No. 1 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.627

Abstract

Background Pleural effusion is an abnormal accumulation of fluid in the pleural cavity, which occurs as a result of disturbance in the balance between production and reabsorption. Cytologycal examination is important as diagnosis, determining the stage, guiding further treatment for malignancy. Effusion fluid is often processed using cytocentrifuge cytology or cell block methods which have their advantages and disadvantages. Calretinin as mesothelial cell marker valuable for establishing a more definitive cytopatholgical diagnosis. Methods Analytic observational study with a cross-sectional approach of 49 samples cytologically diagnosed pleural fluid specimens at private hospital in Medan. Examination method cytocentrifuge cytology and cell block followed calretinin immunohistochemistry. Data analysis was tested with Chi-square test. Results The result of pleural effusion examination were confirmed by calretinin immunohistochemistry, which showed positive mesothelial cell in 45 cases (91,8%), while those who did not show or negative mesothelial cell were 4 cases (8,2%). Conclusion There was a significant different between the result of the cytocentrifuge cytology and cell block methods with a p-value < 0,001.
The Correlation of Immunohistochemical Expression of Matrix Metalloproteinase-9 with Tumor Budding Index and Histopathological Grading in Endometrial Carcinoma Nafilah Yuzar, Devi; Chrestella, Jessy; Ibnu Alferraly, T.; Soekimin, Soekimin; Trisna Mariedina, Causa; Nadjib Dahlan Lubis, M.
Majalah Patologi Indonesia Vol. 34 No. 1 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.643

Abstract

ABSTRACT Background Malignancies of the uterine corpus are the sixth most common malignancy in women, where endometrial carcinoma accounts for the largest number of these cases. Tumor budding has been described as a sign of cancer cell motility and as an early step in the metastatic process. One of the most important aspects of the metastatic process is the correlation between tumor budding and the epithelial mesenchymal transition (EMT), that are characterized by an increase matrix metalloproteinases. One of MMPs is Matrix Metalloproteinase-9 (MMP-9) which plays a role in degrading the extracellular matrix and basement membrane, which is a prerequisite for the process of invasion and metastasis. Method This is an analytic study with a cross sectional approach on 38 surgical samples diagnosed as endometrial carcinoma and then performed with MMP-9 immunohistochemical staining. The statistical analysis was performed to analyze the correlation of immunohistochemical expression of MMP-9 with tumor budding index and histopathological grading in endometrial carcinoma. Results Based on statistical analysis for 38 samples of endometrial carcinoma patients, there was a significant correlation between the immunohistochemical expression of MMP-9 with tumor budding index with p-value: 0.021 and histopathological grading with p-value: 0.005. Conclusion There was a significant correlation between the immunohistochemical expression of MMP-9 with tumor budding index and histopathological grading in endometrial carcinoma, where the immunohistochemical expression of MMP-9 increased at high tumor budding index and histopathological grading as well.
The Correlation of Clinicopathological Characteristics in Clear Cell Renal Cell Carcinoma (ccRCC) with Immunohistochemical Expression of Light Chain 3 B (LC3-B) Dewi Sri Rezeki, Dewi Sri Rezeki; Alferraly, T. Ibnu; Chrestella, Jessy; l, Lidya Imelda; Lukito, Joko S.
Majalah Patologi Indonesia Vol. 34 No. 2 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype in RCTs. This tumor is very aggressive and is often diagnosed at an advanced stage. LC3-B is a specific autophagy marker that plays a role in ccRCC. Research regarding the relationship between clinicopathological characteristics of ccRCC and LC3-B expression is still very limited and controversial. Objective: To assess the relationship between clinicopathological characteristics of ccRCC and LC3-B immunohistochemical expression. Materials and methods: This study used 22 slide samples/paraffin blocks of ccRCC cases that had been diagnosed histopathologically at the Anatomic Pathology Unit of H. Adam Malik General Hospital, Medan from January 2017 to April 2023. All clinicopathological data was taken from medical records/pathology archives. LC3-B expression was assessed in the cytoplasm of tumor cells with assessment semiquantitatively based on the multiplication of intensity and percentage of expressed tumor cells. Statistical analysis was carried out using Fischer's Exact and Kruskal Wallis tests. Results: Among the 22 ccRCC samples, weak expression of LC3-B was found in the age group ≤60 years, male gender, tumor size >10 cm, positive LVI, negative PNI, grade IV, severe stromal TILs, mild intratumoral TILs and low budding in intratumoral budding tumors. Fischer's Exact and Kruskal Wallis statistical tests showed that there was no significant relationship between gender, tumor size, LVI, PNI, ISUP grading, TILs and peritumoral tumor budding with LC3-B expression. Conclusion: There was no significant relationship between clinicopathological characteristics of ccRCC with LC3-B expression (The Null Hypothesis is accepted (H0 ρ=0)). Key words: clinicopathology, ccRCC, LC3-B
Correlation between GATA3 Immunohitsochemistry and TP53 on some Ovarium Carcinoma Histopathology Subtype intan nefia alamanda; Betty, Betty; Delyuzar, Delyuzar; Chrestella, Jessy; Soekimin, Soekimin
Majalah Patologi Indonesia Vol. 34 No. 3 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Ovarian carcinoma is a cancer with high mortality in women, although comprehensive treatment with surgery and chemotherapy is at an advanced stage, survival rates are still low. GATA3 and p53 are predictors of some malignancies, but results vary in ovarian carcinoma. Objective To examine correlation between immunohistochemical expression of GATA3 and p53 in patients with ovarian carcinoma with various histopathological subtypes. Materials and Methods Cross sectional design is the method of this study conducted on slides of 28 ovarian carcinoma patients in several subtypes of hitopathology. Each slide was stained with hematoxylin and eosin (H&E) to assesses hitopathological subtypes and stained with GATA3 and p53 antibodies. Expression GATA3 was assessed using H-score and p53 quick score. A logistic regression assay (p<0.005) was used to assessed the association of GATA3 and TP53 immunohistochemical expression in several histopathological subtypes of ovarian carcinoma. Statistical analysis between GATA3 and p53 was performed using the eta correlation test is used because the data is nominal-ordinal. Results Among 28 specimens in patients with ovarian carcinoma, Cases was most prevalent in the age group >50-60 years (age range 58 years), history of nullipara parity, and most in the group of stage III ovarian malignancy. Positive immunohistochemical p53 expression is more prevalent in serous carcinoma. Positive GATA3 immunohistochemical expression is more prevalent in serous carcinoma. Conclusion There is no significant relationship. Immunohistochemical expression of GATA3 and TP53 in some histopathological subtypes of ovarian carcinoma. However, immunohistochemical expression of GATA3 high p53 positive tends to be found in high-grade serous carcinoma. Keywodrs: GATA3, p53, karsinoma ovarium, Serous carcinoma, Mucinous carcinoma, Endometrioid carcinoma, Clear cell carcinoma.
Co-Authors Alferraly, T. Ibnu Asnir, Rizalina A Basrul, Mohd. Yuwanda Betty betty betty Daulay, Elvita Rahmi Delyuzar, Delyuzar Dewi Sri Rezeki, Dewi Sri Rezeki Farhat Fitri Desimilani, Fitri Desimilani Ibnu Alferraly, T. intan nefia alamanda Intan, T. Kemala Kharismawaty, Dina Kuncara, Dede Bisma l, Lidya Imelda Laksmi, Lidya Imelda Lubis, M. Nadjib Dahlan Lukito, Joko S Lukito, Joko S. Mariedina, Causa Trisna Nadjib Dahlan Lubis, M. Nafilah Yuzar, Devi S Lukito, Joko Soekimin Soekimin, Soekimin Susilo, Riko Trisna Mariedina, Causa Yudhistira, Ashri