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Sinaga, Naomi Juliana
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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GATA3 Expression in Breast Carcinoma: Associations with Clinicopathological Features Sriwidyani, Ni Putu; Dewi, I Gusti Ayu Sri Mahendra; Sinaga, Naomi Juliana; Dewi, Ni Putu Wulan Tantri
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1183

Abstract

Background: Breast carcinoma is a heterogeneous disease, morphologically and molecularly. GATA binding protein 3 (GATA3) is an important marker in breast cancer origin. GATA3 expression and its prognostic value in breast carcinoma are inconsistent. Tumor budding is a small cluster of malignant cells in the invasive edge of the tumor. Breast carcinoma with highgrade tumor budding has an unfavorable prognosis. The objective of this study was to determine whether there is a relationship between GATA3 expression and clinicopathological parameters in breast carcinoma including with tumor budding grade. Another objective of this study was to determine the association between GATA3 expression and other clinicopathological factors with nodal status. Methods: This was a cross-sectional study involving breast carcinoma patients at Prof. Dr. I.G.N.G Ngoerah Hospital during the year 2022 who underwent mastectomy and axillary node dissection. GATA3 expression was determined by immunohistochemistry and categorized into weak and strong expression. Tumor budding was evaluated in Hematoxylin Eosin slides and categorized into low and high grades. The association between GATA3 expressions and clinicopathological parameters, and the association between GATA3 expression and clinicopathological parameters with nodal status, were assessed with a chi-square test with a significance level determined at p 0.05. Results: There were 61 breast carcinoma patients with mastectomy and axillary node dissection that fulfilled inclusion and exclusion criteria. GATA3 expression was significantly associated with the histological type (p = 0.012) and molecular subtype (p 0.001) of the tumor. There was an association between nodal status and molecular subtype of tumor (p = 0.012), tumor stage (p = 0.005), and tumor budding grade (p = 0.024), but there was no association between GATA3 expression and nodal status (p = 0.066). Conclusion: GATA3 expression is associated with the histological type and molecular subtype of tumor in breast carcinoma, but not with nodal status. Nodal status was associated with molecular subtype, T stage, and tumor budding grade of tumor.
Incidental Histopathologic Findings of Uterine Leimyosarcoma in a 58-year-old Woman: A Rare Case Report Paskarani, Putu Erika; Hutapea, N. Yuliance Nurhawati; Widiyanti, Endang Sri; Nini, Cheryl; Sinaga, Naomi Juliana
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1335

Abstract

Introduction: Leiomyosarcoma accounts for (~40–50%) of all uterine sarcomas, but only 1-2% of all uterine malignancies. The incidence of leiomyosarcoma increases with age, reaching its peak in the seventh decade of life. Here, we proposed the importance of macroscopic and microscopic criteria of leiomyosarcoma to ensure clinical diagnosis.Case Presentation: A 58-year-old woman came with vaginal bleeding for 3 weeks before admission to the hospital.  The ultrasonography (USG) examination showed enlargement of the uterus and was clinically diagnosed as a leiomyoma. However, on histopathological examination, a proliferation of anaplastic cells was revealed, forming fasciculi that intersect each other and infiltrate into the connective tissue stroma. Mitosis 15/50 HPF and abnormal mitosis with abrupt coagulative necrosis are easily found. The histopathologic examination concluded that the patient had uterine leiomyosarcoma (pT1a), FIGO stage 1B.Conclusion: Histopathological examination and a clinicoradiological approach are key to identifying leiomyosarcoma. In most cases, although it is confined to the uterus, it has a poor prognosis. Otherwise, this case has a more favorable outcome due to the pathological and clinical stage, with 5-year survival rates of 40 – 70%
Co-Authors Dewi, Ni Putu Wulan Tantri Endang Sri Widiyanti Hutapea, N. Yuliance Nurhawati I Gusti Ayu Sri Mahendra Dewi Ni Putu Sriwidyani Nini, Cheryl Paskarani, Putu Erika