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All Journal Jurnal Sains Teknologi dan Lingkungan (JSTL) Indonesian Journal of Cancer
Nini, Cheryl
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Immunology & microbiology Medicine & Pharmacology Public Health

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Incidental Histopathologic Findings of Uterine Leimyosarcoma in a 58-year-old Woman: A Rare Case Report Paskarani, Putu Erika; Hutapea, N. Yuliance Nurhawati; Widiyanti, Endang Sri; Nini, Cheryl; Sinaga, Naomi Juliana
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1335

Abstract

Introduction: Leiomyosarcoma accounts for (~40–50%) of all uterine sarcomas, but only 1-2% of all uterine malignancies. The incidence of leiomyosarcoma increases with age, reaching its peak in the seventh decade of life. Here, we proposed the importance of macroscopic and microscopic criteria of leiomyosarcoma to ensure clinical diagnosis.Case Presentation: A 58-year-old woman came with vaginal bleeding for 3 weeks before admission to the hospital.  The ultrasonography (USG) examination showed enlargement of the uterus and was clinically diagnosed as a leiomyoma. However, on histopathological examination, a proliferation of anaplastic cells was revealed, forming fasciculi that intersect each other and infiltrate into the connective tissue stroma. Mitosis 15/50 HPF and abnormal mitosis with abrupt coagulative necrosis are easily found. The histopathologic examination concluded that the patient had uterine leiomyosarcoma (pT1a), FIGO stage 1B.Conclusion: Histopathological examination and a clinicoradiological approach are key to identifying leiomyosarcoma. In most cases, although it is confined to the uterus, it has a poor prognosis. Otherwise, this case has a more favorable outcome due to the pathological and clinical stage, with 5-year survival rates of 40 – 70%
Gambaran Ekspresi Cluster of Differentiation 44 (CD44) Pada Meningothelial Meningioma di RSUD Provinsi Nusa Tenggara Barat Santosa, Hilda; Nini, Cheryl; Sabariah, Sabariah; Perdana, Muhammad Astro
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 10 No. 1 (2024): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jstl.v10i1.610

Abstract

Meningiomas are mostly benign tumors that grow slowly and are very common compared to other intracranial tumors with the most frequent subtype being meningothelial meningioma. Cluster of differentiation 44 is a cell surface glycoprotein that has an important role in cellular adhesion, migration, angiogenesis, proliferation and inflammation. This study aims to examine the description of CD44 expression in meningothelial meningioma at West Nusa Tenggara Provincial Hospital. This study is a quantitative descriptive analysis research, sample 27 cases of meningothelial meningioma CD44 expression was evaluated by immunohistochemistry. Quantitative descriptive analysis to determine the percentage of the study sample. The results obtained were 19 (70.40%) age range 41-50 years. CD44 expression in meningothelial meningioma was found to be mild in 3 (11.10%), moderate expression in 5 (18.50%) and strong in 19 (70.40%). In conclusion, most of the percentages of tumor cells that were smeared were in the severe category (percentage value of more than 50 percent).
Co-Authors Endang Sri Widiyanti Hutapea, N. Yuliance Nurhawati Paskarani, Putu Erika Perdana, Muhammad Astro Sabariah Sabariah Santosa, Hilda Sinaga, Naomi Juliana