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All Journal Jurnal Anestesiologi Indonesia Jurnal Anestesi Perioperatif
Ramud, Samawi Husein
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Education Health Professions Medicine & Pharmacology Public Health

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PERBANDINGAN FLUOKSETIN 20 MG DENGAN AMITRIPTILIN 12,5 MG SEBAGAI ADJUVAN KOMBINASI PARASETAMOL DAN MORFIN DALAM MENGURANGI NYERI PADA PASIEN NYERI KANKER Ramud, Samawi Husein; Hamdi, Tasrif; Bangun, Chrismas Gideon; Yunanda, Yuki
Jurnal Anestesi Perioperatif Vol 12, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15851/jap.v12n3.3628

Abstract

Data WHO menunjukkan bahwa 30–40% pasien kanker mengalami nyeri sedang atau berat. Empat kelas obat antidepresan dapat dipakai dalam pengobatan nyeri neuropatik. Penelitian ini bertujuan untuk mengetahui perbandingan fluoksetin 20 mg dengan amitriptilin 12,5 mg sebagai adjuvant kombinasi parasetamol 1000 mg dalam mengurangi gejala nyeri pada pasien nyeri kanker. Penelitian dilaksanakan sejak Juli–September 2023 di klinik nyeri Rumah Sakit Umum Pusat Haji Adam Malik Medan. Penelitian ini adalah uji klinis acak tersamar. Sebanyak 40 subjek dibagi dalam 2 kelompok. Kelompok A (n=20) mendapat fluoksetin, morfin dan parasetamol, sedangkan kelompok B (n=20) mendapat amitriptilin, morfin dan parasetamol. Skor nyeri pada subjek diukur dengan menggunakan PainDETECT. Data dianalisis secara univariat dan bivariat. Data bivariat dianalisis dengan uji Chi-Square, T-Test Independent, T-Test Paired dan Mann-Whitney. Terdapat penurunan skor numeric rating scale dan PainDETECT yang signifikan antara sebelum dan setelah pemberian fluoksetin maupun amitriptilin dengan nilai p<0,05. Kelompok fluoksetin maupun amitriptilin dapat menurunkan skor numeric rating scale dan PainDETECT secara statistik, akan tetapi tidak bermakna secara klinis.
Comparison of Fluoxetine (20 Mg) and Amitriptyline (12.5 Mg) As Adjuvants for The Combination of Paracetamol and Morphine in Cancer Patients' Pain Relief Ramud, Samawi Husein; Hamdi, Tasrif; Bangun, Chrismas Gideon; Yunanda, Yuki
JAI (Jurnal Anestesiologi Indonesia) Vol 17, No 1 (2025): JAI (Jurnal Anestesiologi Indonesia)
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.59070

Abstract

Background: Pain is one of the most common symptoms in cancer which affects 30–50% of patients on average and rises to 70–90% in cases of advanced disease. As cancer advances, so does the frequency of discomfort associated with the illness. When cancer is detected in its terminal stage, 30–40% of patients report experiencing moderate pain, and 60–100% report experiencing severe pain. Tricyclic antidepressants (TCAs), selective serotonin and norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAOIs) are the four families of antidepressant medications that have been investigated for use in the treatment of neuropathic pain.Objective: This research was conducted at the pain clinic of Adam Malik Hospital, this study intends to compare the effectiveness of fluoxetine with amitriptyline as an adjuvant to the combination of paracetamol and morphine in reducing pain symptoms in cancer patients.Methods: This study was designed as a randomized, double-blind clinical experiment. The study was carried out in 2023 between July and September. Two groups of forty research participants receiving outpatient care at the pain clinic were formed. Fluoxetine, morphine, and paracetamol were administered to group A (n = 20), whereas amitriptyline, morphine, and paracetamol were administered to group B (n = 20). PainDETECT was used to measure the subjects' pain scores. Both univariate and bivariate data analysis was done. The Chi-Square test, Independent T-test, Paired T-test, and Mann-Whitney were used to examine the bivariate data.Result: The delivery of amitriptyline and fluoxetine resulted in a substantial reduction in PainDETECT scores, with a p-value of less than 0.05.Conclusion: This study show that PainDETECT score was statistically reduced in both the fluoxetine and amitriptyline groups but the reduction was not clinically meaningful because the target score drop was less than 4 on a scale of 0–10, or a 50% reduction in pain.
Co-Authors Bangun, Chrismas Gideon Hamdi, Tasrif Yunanda, Yuki