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All Journal MDJ (Makassar Dental Journal)
Thalib, Alqarama Mahardhika
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Dentistry

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Potential Stichopus hermanii as a gingivitis inhibitor: Potensi Stichopus hermanii sebagai penghambat gingivitis Amin, Asmawati; Aryadifa, Muhammad Arif; Rajab, Nur Indasari; Thalib, Alqarama Mahardhika; Thalib, Bahruddin; Zaizafun, Ainiyyah Fildza; Reni, Delvi Sintia
Makassar Dental Journal Vol. 13 No. 3 (2024): Volume 13 Issue 3 Desember 2024
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v13i3.1096

Abstract

Gingivitis is a response to the buildup of bacterial plaque, characterized by symptoms such as bleeding, swelling, redness, and exudate. One of the marine biotas widely found in Indonesia is the golden sea cucumber (Stichopus hermanii), which contains va-rious bioactive components such as proteins, hyaluronic acid, chondroitin sulfate, EPA, DHA, and flavonoids. This systematic re-view aims to reveal the potential of Stichopus hermanii as a gingivitis inhibitor. The method used follows a systematic review ap-proach, adhering to the guidelines of the preferred reporting items for systematic reviews and meta-analyses (PRISMA). A total of 8 studies met the eligibility criteria to be included in this systematic review. It is concluded that the use of Stichopus hermanii has the potential to effectively reduce gingivitis.
Morphological description of tooth surfaces after application of casein phosphopeptide-amorphous calcium phosphate paste : Gambaran morfologi permukaan gigi pasca-aplikasi pasta casein phosphopeptide-amorphus calcium phosphate Said, Annisa Rahma; Amin, Asmawati; Talib, Bahruddin; Thalib, Alqarama Mahardhika
Makassar Dental Journal Vol. 14 No. 3 (2025): Volume 14 Issue 3 December 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v14i3.1293

Abstract

The use of hydrogen peroxide bleaching agents can disrupt tissue permeability, causing lesions due to the demineralisation pro-cess caused by the acidic nature of the bleaching agent. A remineralisation agent is required. Casein phosphopeptide-amorph-ous calcium phosphate (CPP-ACP) is a widely used material in preventive dentistry and has been proven to provide protection against acid. This article provides an overview of the surface morphology of teeth treated with CPP-ACP paste. The study was an experimental laboratory design with a pre-posttest and control group. Ten samples were evenly divided into two groups: control and treatment. The control samples were immersed in artificial saliva for 24 hours and then rinsed with distilled water. The treat-ment samples were treated with 35% hydrogen peroxide for 2 hours, then cleaned with distilled water and observed using SEM. Subsequently, CPP-ACP paste was applied every 8 hours for 14 consecutive days, followed by SEM observation. CPP-ACP paste was found to help inhibit demineralisation and enhance the remineralisation process of teeth. It was concluded that teeth treated with CPP-ACP paste appeared smooth with minimal shallow scratches and exhibited porosity around them with small pore sizes.
Potential of Stichopus hermanni as a scaffold material in dental tissue engineering: Potensi Stichopus hermanni sebagai bahan penyangga dalam rekayasa jaringan gigi Amin, Asmawati; Thalib, Alqarama Mahardhika; Thalib, Bahruddin; Fauzan, Muhammad Fadil; Sambara, Eser Suryanti
Makassar Dental Journal Vol. 14 No. 3 (2025): Volume 14 Issue 3 December 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v14i3.1398

Abstract

This article evaluates Stichopus hermanni as a scaffold for dental tissue engineering, focusing on biocompatibility, osteogenesis, angiogenesis, and immunomodulation. A systematic literature was conducted through PubMed/MEDLINE, Scopus, ScienceDi- rect, Google Scholar, and national databases. Studies were selected using the PICOS framework, covering both in vitro and in vivo research. The results showed that S.hermanni-based scaffolds, either alone or in combination with hydroxyapatite or chito-san, exhibited high biocompatibility, non-toxicity, increased osteogenic markers (CD44, IL-10, osteocalcin, bFGF), angiogenesis, and woven bone formation. This scaffold also reduced osteoclast activity through immunomodulatory effects. It was concluded that S.hermanni has strong potential as a biomaterial scaffold in dental tissue engineering, supporting the safe and effective re-generation of hard and soft tissues.
Co-Authors Amin, Asmawati Aryadifa, Muhammad Arif Bahruddin Thalib Fauzan, Muhammad Fadil Rajab, Nur Indasari Reni, Delvi Sintia Said, Annisa Rahma Sambara, Eser Suryanti Talib, Bahruddin Zaizafun, Ainiyyah Fildza