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All Journal MDJ (Makassar Dental Journal)
Sambara, Eser Suryanti
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Dentistry

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Potential of Stichopus hermanni as a scaffold material in dental tissue engineering: Potensi Stichopus hermanni sebagai bahan penyangga dalam rekayasa jaringan gigi Amin, Asmawati; Thalib, Alqarama Mahardhika; Thalib, Bahruddin; Fauzan, Muhammad Fadil; Sambara, Eser Suryanti
Makassar Dental Journal Vol. 14 No. 3 (2025): Volume 14 Issue 3 December 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v14i3.1398

Abstract

This article evaluates Stichopus hermanni as a scaffold for dental tissue engineering, focusing on biocompatibility, osteogenesis, angiogenesis, and immunomodulation. A systematic literature was conducted through PubMed/MEDLINE, Scopus, ScienceDi- rect, Google Scholar, and national databases. Studies were selected using the PICOS framework, covering both in vitro and in vivo research. The results showed that S.hermanni-based scaffolds, either alone or in combination with hydroxyapatite or chito-san, exhibited high biocompatibility, non-toxicity, increased osteogenic markers (CD44, IL-10, osteocalcin, bFGF), angiogenesis, and woven bone formation. This scaffold also reduced osteoclast activity through immunomodulatory effects. It was concluded that S.hermanni has strong potential as a biomaterial scaffold in dental tissue engineering, supporting the safe and effective re-generation of hard and soft tissues.
Co-Authors Amin, Asmawati Bahruddin Thalib Fauzan, Muhammad Fadil Thalib, Alqarama Mahardhika