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All Journal MPI (Media Pharmaceutica Indonesiana) Jurnal Inovasi Teknik Kimia
Lasmono, Roisa Zakia Zahra
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Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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The Efficacy of Watermelon (Citrullus lanatus) Rind Extract in Healing Burns in Balb/C Male Mice Megahandayani, Siti Wahyuputri; Mahastari, Nur Lailiyah Yoan; Lasmono, Roisa Zakia Zahra; Jannah, Siti Nur; Affifah, Virmin Rahma; Siddiq, Hadi Barru Hakam Fajar
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 1 (2023): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i1.5241

Abstract

Burns are skin tissue damage that occurs as a result of direct contact with a heat source. One of the natural treatments for burns is watermelon (Citrullus lanatus) rind. Watermelon rind contains citrulline, an alkaloid that plays a role in wound healing. This study aims to explore the potential of watermelon rind to become extract gel as a burn remover in male Balb/C strain mice. This research method is a true experiment that begins with the preparation of watermelon rind extract by maceration with ethanol. Furthermore, the polyphenol, flavonoid, saponin, and alkaloid content of the extract was identified through the phytochemical screening. The next stage was the preparation of a gel with three variations of extract concentrations, namely 25%, 50%, and 75% w/v. The gels were characterized by organoleptic, pH, and spreadability. The final stage tested the gel’s activity as a burn wound healing in male Balb/C strain mice. The results showed that the extract contained saponins, polyphenols, flavonoids, and alkaloids. The spreadability test results of the gel showed that all gels met the requirements. All gels had activity against burns in male Balb/C strain mice. Thus, watermelon rind extract can be used as a medicine for burns.
Green Synthesis dan Karakterisasi Nanopartikel Emas Sebagai Antioksidan Peredam Radikal Bebas Paramita, Denok Risky Ayu; Siddiq, Hadi Barru Hakam Fajar; Lasmono, Roisa Zakia Zahra
Jurnal Inovasi Teknik Kimia Vol. 11 No. 2 (2026): APRIL | INTEKA - Jurnal Inovasi Teknik Kimia
Publisher : Fakultas Teknik Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/inteka.v11i2.13258

Abstract

Gold nanoparticles (AuNPs) have significant potential in healthcare due to their antioxidant activity. However, conventional physical and chemical synthesis methods are costly and generate hazardous waste. Green synthesis offers a more economical and environmentally friendly alternative. In this study, katuk leaf extract was used for the first time as a reducing agent in the green synthesis of AuNPs, owing to its rich phenolic content. The aim of this research was to synthesize and characterize AuNPs using katuk leaf extract and to evaluate their antioxidant activity against free radicals. UV–Vis spectrophotometry showed an optimum wavelength at 530 nm, indicating the formation of wine-red AuNPs. SEM analysis revealed spherical particles with sizes ranging from 28 to >100 nm. XRD results, based on JCPDS No. 04-0784, confirmed a face-centered cubic (FCC) crystalline structure with Bragg reflections at 2θ values of 38.03°, 44.15°, 64.25°, and 77.25°, corresponding to (111), (200), (220), and (311) planes. DPPH analysis yielded an IC₅₀ value of 53.37, indicating strong antioxidant activity and potential applications in the health sector.
Co-Authors Affifah, Virmin Rahma Denok Risky Ayu Paramita Hadi Barru Hakam Fajar Siddiq Mahastari, Nur Lailiyah Yoan Megahandayani, Siti Wahyuputri Siti Nur Jannah