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All Journal Jurnal Health Sains DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN
Amma, Fuad
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Effect of Ashitaba Extract on Cholesterol in Wistar Rats given a high-fat diet and computational lethal dose test Widyaningsih, Indah; Sugiharto, Natsya Nurulita; Rahmawati, Febtarini; Amma, Fuad; Simamora, Dorta
Dunia Keperawatan: Jurnal Keperawatan dan Kesehatan Vol 12 No 2 (2024): Dunia Keperawatan: Jurnal Keperawatan dan Kesehatan
Publisher : School of Nursing, Faculty of Medicine and Health Science, Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jdk.v12i2.570

Abstract

High levels of cholesterol in the blood can cause various health problems, namely atherosclerosis, stroke, coronary heart disease, to hypertension. One drug option for someone with hypercholesterolemia is simvastatin. In addition to the use of the drug simvastatin, can take medicinal plants. A medicinal plant that can help lower high cholesterol levels is Ashitaba leaf extract (Angelica keiskei). One of the ingredients in ashitaba extract is xanthoangelol E, Ashitaba chalcones, which can reduce cholesterol synthesis. The purpose of this study was to determine the effect of ashitaba extract (Angelica keiskei) on the cholesterol levels of Wistar rats (Rattus novergiccus) given a high-fat diet. In this study, a computational lethal dose test was also carried out. The population in this study was male white rats of the Wistar strain with samples taken from as many as 30 heads. Data analysis of this study used the One Way Anova statistical test. The results showed that giving ashitaba extract 150mg/kg body weight, 300mg/kg body weight, and 600mg/kg body weight did not affect the cholesterol levels of Wistar rats given a high-fat diet. This is proven by the results of the ANOVA test obtained a significance value of 0.761 > 0.05. Research on the toxic effects of ashitaba extract needs to be done for further research.
Effect of Ashitaba Extract on Cholesterol in Wistar Rats Given a High-Fat Diet and Computational Lethal Dose Test Widyaningsih, Indah; Nurulita Sugiharto, Natasya; Rahmawati, Febtarini; Amma, Fuad; Simamora, Dorta
Jurnal Health Sains Vol. 5 No. 10 (2024): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i10.1365

Abstract

High cholesterol levels in the blood can cause various health problems, namely atherosclerosis, stroke, coronary heart disease, and hypertension. One drug option for someone with hypercholesterolemia is simvastatin. Apart from using simvastatin, you can consume medicinal plants. A medicinal plant that can help reduce high cholesterol levels is Ashitaba (Angelica keiskei) leaf extract. One of the ingredients in Ashitaba extract is xanthoangelol E, Ashitaba chalcones, which can reduce cholesterol synthesis. The aim of this research was to determine the effect of ashitaba (Angelica keiskei) extract on the cholesterol levels of Wistar rats (Rattus novergiccus) given a high-fat diet. In this study, a computational lethal dose test was also carried out. The population in this study was male white rats of the Wistar strain with 30 samples taken. Analysis of this research data uses the One Way Anova statistical test. The results of the study showed that giving ashitaba extract 150mg/kg BW, 300mg/kg BW, and 600mg/kg BW had no effect on the cholesterol levels of Wistar rats given a high-fat diet. This is proven by the results of the Anova test which obtained a significance value of 0.761 > 0.05. Research regarding the toxic effects of ashitaba extract needs to be carried out for further research.
Co-Authors Dorta Simamora Febtarini Rahmawati Indah Widyaningsih Nurulita Sugiharto, Natasya Sugiharto, Natsya Nurulita