Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Berkala Ilmiah Kimia Farmasi Jurnal Pengembangan Ilmu dan Praktik Kesehatan
Priolaningsih, Dhela Rahma
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
UJI MUTU FISIK DAN STABILITAS SEDIAAN TRANSDERMAL ANTIPIRETIK EKSTRAK ETANOL DAUN DADAP SEREP (Erythrina Subumbrans (Hassk.) Merr) Priolaningsih, Dhela Rahma; Susilowati, Arikha Ayu; Wulandari, Raden Roro Sri
Pengembangan Ilmu dan Praktik Kesehatan Vol. 3 No. 6 (2024): Volume 3, Nomor 6, Desember 2024
Publisher : STIKES Dian Husada Mojokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56586/pipk.v3i6.411

Abstract

Naiknya temperatur tubuh (febris) merupakan salah satu gejala dari suatu penyakit, yang dapat diobati secara farmakologi dan non farmakologi, sebagian lebih memilih secara non farmakologi karena untuk menghindari gangguan penyerapan obat di saluran pencernaan. Daun dadap serep (Erythrina subumbrans (Hassk.) Merr) dengan kandungan saponin, flavonoid, tanin, dan alkaloid berpotensi untuk menurunkan temperatur tubuh. Tujuan penelitian ini membuat formulasi sediaan transdermal Ekstrak Etanol Daun Dadap Serep (EEDDS) ekstraksi sokletasi dengan hasil konsentrasi 10%, 20%, dan 40%. Penelitian ini merupakan eksperimental laboratorium, evaluasi sediaan menggunakan uji mutu fisik dan uji stabilitas dengan metode freeze-thaw. Hasil penelitian menunjukkan uji mutu fisik dan stabilitas keseragaman bobot rata-rata %CV 2,50 dan 3,25, ketebalan 0,0867 dan 0,0967, ketahanan lipat ≥300 dan ≥300, pH 6,8 dan 6,9. Evaluasi sediaan transdermal EEDDS menunjukkan kestabilan yang baik bahkan setelah dilakukan uji stabilitas mutu fisik dengan metode freeze-thaw. Disimpulkan formulasi sediaan transdermal EEDDS yang paling baik pada konsentrasi 40%
Uji Efektivitas Transdermal Patch Antipiretik Ekstrak Daun Dadap Serep (Erythrina Subumbrans (Hassk.) Merr) terhadap Mencit Putih (Mus Musculus) Model Hipertermia Priolaningsih, Dhela Rahma; Susilowati, Arikha Ayu; Cahyaningrum, Yanuar As’hari
Berkala Ilmiah Kimia Farmasi Vol. 12 No. 1 (2025): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v12i1.61759

Abstract

Dadap serep leaves (Erythrina subumbrans (Hassk.) Merr) contained saponins, flavonoids, tannins, and alkaloids which had the potential to lower body temperature. This research aimed to formulate a stable transdermal patch of Dadap Serep Leaf Extract (EDDS) and evaluate this transdermal patch based on temperature changes in white mice (Mus musculus) hyperthermia models at 17, 20, and 40%. This research was an experimental laboratory with a pre- and post-test control group design to test the effectiveness of the EDDS transdermal patch. Evaluation of the patch used physical quality stability tests using the freeze-thaw method including organoleptic, weight uniformity, thickness, folding resistance, and pH. Then the effectiveness test of this EDDS transdermal patch was tested on a white mouse hyperthermia model. The treatment group consisted of positive control (marketed compress product), negative control (peptone induction), and transdermal patch with EDDS extract at 17, 20, and 40% for 2 hours with monitoring every 30 minutes. The results showed that the transdermal patch preparation had good stability after physical quality stability testing using the freeze-thaw method. It was concluded that the most effective EDDS transdermal patch formulation in reducing temperature in white mice was a concentration of 40% with a temperature reduction percentage of 84.5%.   Keywords:  Transdermal Patch, Hipertermia, Dadap Serep Leaves, Soxhletation, Freeze-thaw
Co-Authors Cahyaningrum, Yanuar As’hari Susilowati, Arikha Ayu Wulandari, Raden Roro Sri