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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Berkala Ilmiah Kimia Farmasi
Cahyaningrum, Yanuar As’hari
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience

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FORMULASI DAN STABILITAS SERUM WAJAH SARANG BURUNG WALET PUTIH (Collocalia fuchiphaga) SEBAGAI ANTIAGING Olipiya, Olipiya; Nurmaulawati, Rina; Cahyaningrum, Yanuar As’hari
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p8-16

Abstract

White swallow's nest (Collocalia fuchiphaga) is known to have benefits as an antioxidant so it can prevent skin aging. Serum preparations have advantages as skin care cosmetics because they contain active substances in high concentrations, are light and easy to apply. This study aims to make formulations, test physical quality, physical stability, irritation in test animals and test antioxidant activity using the DPPH method (2,2-diphenyl-1-picrylhydrazyl) as a facial serum containing white swallow's nest (Collocalia fuchiphaga) . In this study, a facial serum formulation containing white swallow's nest (Collocalia fuchiphaga) was prepared with various concentrations of 10%, 20% and 30%. The results showed that the 3 formulations had good physical quality tests based on the results of tests carried out in accordance with the standards. Based on the results of the physical stability test, the test results on pH, spreadability and viscosity showed no change in storage for 28 days. The antioxidant activity test results of the 3 formulations yielded IC50 values ​​of F1 (52.523 ppm), F2 (52.181 ppm), and F3 (51.165 ppm). The formulation of white swallow's nest serum (Collocalia fuchiphaga) does not cause primary irritation to rabbit test animals. Based on the results of the data analyzed statistically with a confidence level of 95%, the data obtained was p> 0.05 so that the 3 formulas showed no significant difference. It can be concluded from this study that facial serum containing white swallow's nest (Collocalia fuchiphaga) can be used as an antiaging preparation and does not irritate the skin.
Uji Efektivitas Transdermal Patch Antipiretik Ekstrak Daun Dadap Serep (Erythrina Subumbrans (Hassk.) Merr) terhadap Mencit Putih (Mus Musculus) Model Hipertermia Priolaningsih, Dhela Rahma; Susilowati, Arikha Ayu; Cahyaningrum, Yanuar As’hari
Berkala Ilmiah Kimia Farmasi Vol. 12 No. 1 (2025): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v12i1.61759

Abstract

Dadap serep leaves (Erythrina subumbrans (Hassk.) Merr) contained saponins, flavonoids, tannins, and alkaloids which had the potential to lower body temperature. This research aimed to formulate a stable transdermal patch of Dadap Serep Leaf Extract (EDDS) and evaluate this transdermal patch based on temperature changes in white mice (Mus musculus) hyperthermia models at 17, 20, and 40%. This research was an experimental laboratory with a pre- and post-test control group design to test the effectiveness of the EDDS transdermal patch. Evaluation of the patch used physical quality stability tests using the freeze-thaw method including organoleptic, weight uniformity, thickness, folding resistance, and pH. Then the effectiveness test of this EDDS transdermal patch was tested on a white mouse hyperthermia model. The treatment group consisted of positive control (marketed compress product), negative control (peptone induction), and transdermal patch with EDDS extract at 17, 20, and 40% for 2 hours with monitoring every 30 minutes. The results showed that the transdermal patch preparation had good stability after physical quality stability testing using the freeze-thaw method. It was concluded that the most effective EDDS transdermal patch formulation in reducing temperature in white mice was a concentration of 40% with a temperature reduction percentage of 84.5%.   Keywords:  Transdermal Patch, Hipertermia, Dadap Serep Leaves, Soxhletation, Freeze-thaw
Co-Authors Nurmaulawati, Rina Olipiya, Olipiya Priolaningsih, Dhela Rahma Susilowati, Arikha Ayu