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Raymond R Tjandrawinata
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Nyeri Neuropati: Tantangan dan Perkembangan dalam Manajemen Berbasis Bukti Raymond R Tjandrawinata
MEDICINUS Vol. 38 No. 4 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/fqbssh75

Abstract

Nyeri neuropati merupakan kondisi kronis akibat disfungsi sistem saraf somatosensori yang memerlukan pendekatan terapi multimodal untuk mengoptimalkan manajemen nyeri. Pregabalin, sebagai agen farmakoterapi utama, bekerja dengan menurunkan eksitabilitas neuron melalui modulasi kanal kalsium tipe alfa-2-delta, menunjukkan efektivitas dalam mengurangi gejala nyeri neuropati dengan profil farmakokinetik yang lebih unggul dibandingkan gabapentin. Pendekatan nonfarmakologis, seperti cognitive behavioral therapy (CBT) dan stimulasi listrik noninvasif, juga berperan dalam meningkatkan kualitas hidup pasien. Dengan berkembangnya penelitian terhadap agen terapi baru seperti cannabinoid dan mirogabalin, serta pendekatan berbasis personalisasi, strategi manajemen nyeri neuropati terus mengalami inovasi untuk meningkatkan efektivitas dan tolerabilitas terapi.
Tiga Pilar Pertahanan Tubuh Terhadap Influenza: Vaksin, Terapi Antivirus, dan Imunomodulator dalam Perspektif Kedokteran Preventif dan Kuratif Raymond R Tjandrawinata
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/dkbt5b68

Abstract

Influenza is an acute respiratory infection that continues to pose a global health threat due to its high morbidity and mortality burden. In order to overcome this challenge effectively, an integrative approach is required, encompassing three main pillars: annual vaccination adapted to virus mutation dynamics, the use of antiviral agents targeting viral RNA replication, and immune system strengthening through herbal-based immunomodulators and essential micronutrients. This paper emphasizes the importance of synergy between preventive and curative efforts in modern public health strategies.Immunomodulation, which includes a combination of phytocomponents with vitamin C and zinc, has been shown to enhance innate and adaptive immune responses, improve protection to infection, and support recovery processes.An evidence-based approach integrating these three elements is considered the most relevant strategy for addressing influenza virus evolution and strengthening the population's immunological resilience.
Co-Authors Teguh Prasetyo