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All Journal Eksakta : Berkala Ilmiah Bidang MIPA Science Education and Application Journal Pena Medika : Jurnal Kesehatan
Ahmad, Nouman
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Energy Engineering Environmental Science Health Professions Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Climate Change Shapes the Dengue Landscape: A Narrative Review Ahmad, Nouman; Ahmad, Hamdan
Pena Medika : Jurnal Kesehatan Vol. 14 No. 2 (2024): PENA MEDIKA: JURNAL KESEHATAN
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/pmjk.v14i2.5401

Abstract

Introduction: Climate change is a critical driver of vector-borne diseases, notably dengue. Rising global temperatures, altered precipitation patterns, and increased extreme weather events enhance Aedes mosquitoes' habitats, the primary vectors of dengue. The pathogenesis of dengue, driven by any of the four serotypes of the dengue virus (DENV-1 to DENV-4), is exacerbated by climate-induced changes that support mosquito breeding and survival. Methods: This review analyzes selective studies from the last decade, integrating epidemiological data and climate models to explore the impacts of climatic variables on dengue dynamics. Adaptation strategies, including vaccination, vector control, and community-based interventions, were evaluated for their effectiveness in mitigating dengue transmission Results: Epidemiological data indicate approximately 390 million annual infections globally, with rapid urbanization and inadequate vector control compounding the issue. Climate models highlight significant increases in dengue incidence and shifts in its geographic distribution, particularly in regions such as the Americas, Asia, and potentially Europe. Promising adaptation strategies, such as the Communication for Behavioral Impact (COMBI) plan and constrained optimization models, have demonstrated efficacy in enhancing dengue prevention and control. Discussion: As climate change continues to alter ecosystems, integrating climatic data into public health strategies is essential for adaptive responses. Comprehensive and region-specific approaches, robust public health infrastructures, and international cooperation are paramount to address the rising threat of dengue. A need for international cooperation and robust public health infrastructure is necessary to address the multifaceted challenges posed by climate change on dengue transmission
6-Gingerol Slightly Reduces Hepatic Endoplasmic Reticulum Stress Markers in Rats with High-Fat, High-Fructose Diet-Induced Metabolic Syndrome Ahmad, Nouman; Syarifah Dewi; Soetikno, Vivian
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 01 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss01/581

Abstract

Metabolic syndrome (MetS) is linked to hepatic endoplasmic reticulum (ER) stress. This study evaluated 6-gingerol’s potential to alleviate ER stress in a high-fat high-fructose (HFHF)-induced MetS rat model. Male Sprague-Dawley rats (8 weeks, 180–220 g) were assigned to five groups: Normal, HFHF, and HFHF with 6-gingerol (50, 100, or 200 mg/kg). The Normal group received a standard diet, while others had HFHF for 16 weeks. From Week 8, intervention groups received 6-gingerol daily. Except for Normal, other groups also received Streptozotocin (22mg/kg, i.p.) at Week 8. At Week 16, rats were euthanized, and liver tissues collected to assess ER stress markers (GRP78, IRE1, TRAF2, PERK, CHOP) via qPCR and apoptotic markers (Bax, Bcl-2) via ELISA. 6-Gingerol slightly reduced liver ER stress markers, including GRP78 (P=0.392), CHOP (P=0.798), IRE1 (P=0.419), TRAF2 (P=0.470), and PERK (P=0.357), but these changes were not significant. Similarly, apoptotic markers Bax and Bcl-2 showed no significant differences, though the Bax/Bcl-2 ratio decreased (P=0.186). These results indicate that 6-gingerol had only a slight effect on ER stress and apoptosis within the parameters of this experiment.
Antiviral Properties and Potential of Ginger (Zingiber Officinale) and Its Derivatives: A Systematic Review Ahmad, Nouman; Ahmad, Hamdan; Dewi Syarifah; Vivian Soetikno
Science Education and Application Journal Vol 7 No 2 (2025): Science Education and Application Journal
Publisher : Program Studi Pendidikan IPA, Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/seaj.v7i2.1205

Abstract

Antiviral Properties and Potential of Ginger (Zingiber Officinale) and Its Derivatives: A Systematic Review. Ginger has long been valued in traditional medicine for its therapeutic benefits. Recently, its antiviral capabilities have attracted significant interest, highlighting its potential as a natural antiviral agent. This systematic review seeks to thoroughly evaluate the antiviral effects of ginger and its active compounds, providing valuable insights to support future research and clinical applications in natural antiviral therapies. A comprehensive electronic search was undertaken across PubMed, Embase, and Scopus databases, employing MeSH terms, Emtree, and relevant synonyms to capture studies on ginger and its antiviral effects. The initial search yielded 531 records, which were de-duplicated and subsequently screened by title and abstract using Rayyan software. Fourteen studies specifically addressing antiviral effects against human pathogens met the inclusion criteria. This systematic review was conducted in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure rigorous reporting of findings. The majority of included studies were in vitro, revealing anti-viral effects of ginger against various viruses, including Influenza A, Chikungunya, Dengue, hRSV, HSV-2, and SARS-CoV-2 in different cell lines across various concentrations. In addition, Ginger extracts also demonstrated efficacy against Influenza A in both in vivo and in ovo studies, and a randomized controlled trial showcased encouraging antiviral effects targeting SARS-CoV-2. Ginger shows promising antiviral effects in most of the in vitro studies. Translating these findings to in vivo models is imperative for clinical relevance. Further in vivo research is essential before progressing to human studies to ascertain ginger's potential as an effective antiviral agent
Co-Authors Dewi Syarifah Hamdan Ahmad Syarifah Dewi Vivian Soetikno