Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Medical Journal of Indonesia Acta Pharmaciae Indonesia : Acta Pharm Indo
Shah Faisal
Sarhad University of Science and Information Technology Peshawar Khyber PakhtunKhwa
Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Potential drug-drug interactions in elderly patients in a renal ward: a single-center retrospective study in Pakistan Ahmad, Nouman; Ramadhan, Andika Yusuf; Mahmood, Asif; Faisal, Shah
Acta Pharmaciae Indonesia Vol 12 No 2 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.2.15510

Abstract

Background: The increasing prevalence of kidney disease among elderly populations has led to a rise in potential drug-drug interactions (pDDIs), particularly due to widespread polypharmacy use in this demographic. Objective: This study aims to retrospectively analyze pDDIs and identify their prevalence and associated factors among elderly patients in a renal ward. Methods: This retrospective observational study was conducted at Saidu Group of Teaching Hospital in Swat, Pakistan, from January to December 2022. Data were obtained from the Patients Records Office using a conventional paper-based record system. A sample of 43 elderly patients (age ≥60 years) was selected through consecutive sampling. Drug interactions were assessed using freely available online tools: Drugs.com and Medscape Drug Checker, selected for their user-friendly accessibility and suitability in resource-limited settings. Results: Among the 43 elderly subjects with balanced gender distribution, the mean age was 66.53 ± 7.68 years. Comorbidities were present in 74.4% of patients, and each patient was prescribed an average of 4.58 medications. According to Medscape, 62.79% of patients experienced one or more potential drug interactions, while Drugs.com identified interactions in 67.44% of cases. Notably, 15% of these interactions were classified as high-risk by both tools. Logistic regression analysis indicated a significantly higher risk of potential drug interactions with increasing numbers of prescribed medications (OR = 4.515, p = 0.033). Conclusion: This study identified a high prevalence of pDDIs among elderly patients with kidney disease in Pakistan. The majority had comorbidities necessitating multiple medications, thereby increasing the risk of adverse drug reactions (ADRs). Mitigating these risks requires accurate prescribing practices, reliable electronic surveillance systems, and clinical pharmacist support.
Factors contributing to the prevalence of potential drug-drug interactions among hospitalized elderly patients in a tertiary hospital in Eastern Java, Indonesia Faisal, Shah; Khotib, Junaidi; Wibisono, Cahyo; Hamidah, Khusnul Fitri; Utomo, Febriansyah Nur; Zairina, Elida
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257888

Abstract

BACKGROUND Drug-drug interactions (DDIs) are the primary cause of adverse drug events. However, studies on potential DDIs (pDDIs) in hospitalized older adult patients in Indonesia remain limited. Therefore, this study aimed to investigate the prevalence and potential risk factors of pDDIs in this population. METHODS A prospective observational study assessing the medical profiles of hospitalized elderly patients was conducted at Universitas Airlangga Hospital from September 2023 to February 2024. Patient characteristics were recorded, and Micromedex® Drug-Reax software was used to check the pDDIs. Ethical approval was obtained for this study (No. 078/KEP/2023). Data were analyzed using SPSS software (version 26). RESULTS Of the 409 patients, 41.9% of the prescriptions contained pDDIs. Furthermore, 73 prescriptions (17.1%) had at least one pDDI, with 1–6 interactions per prescription. Of the 369 identified pDDIs, 209 (56.6%) were major interactions. Logistic regression analysis revealed increased odds of pDDIs in patients with previous medication use (adjusted odds ratio [aOR] = 2.254; crude odds ratio (cOR] = 1.771), polypharmacy (aOR = 16.309; cOR = 11.709), circulatory diseases (aOR = 4.082; cOR = 4.788), and genitourinary diseases (aOR = 1.819; cOR = 1.855). Conversely, patients with digestive system diseases had a significantly lower risk (aOR = 0.573; cOR = 0.608). CONCLUSIONS This study found a high prevalence of pDDIs (41.1%) among older hospitalized patients in Indonesia. Modifiable factors, such as polypharmacy and previous medication use, can reduce the risk of pDDIs and avoid adverse events.
Co-Authors Ahmad, Nouman Elida Zairina Hamidah, Khusnul Fitri Junaidi Khotib Mahmood, Asif Ramadhan, Andika Yusuf Utomo, Febriansyah Nur Wibisono, Cahyo