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All Journal Media Farmasi Indonesian Journal of Pharmacology and Therapy
Rasyidah, Jamiatur
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Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Media Farmasi

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In-Silico Analysis of Momordica charantia L. As Antidiabetic Agents Through Activation of Human UDP-Galactose 4-Epimerase Receptors Pramesthi, Asri Dwi Endah Dewi; Suwarno, Kafka Navisa; Pratama, Aldo; Rasyidah, Jamiatur; I Wayan Surya Rahadi; Rasida, Rima
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.1002

Abstract

This study investigates the antidiabetic potential of compounds found in Momordica charantia L., commonly known as bitter melon, through molecular docking and ADME (Absorption, Distribution, Metabolism, and Excretion) analysis. Utilizing in silico methods, several bioactive compounds from bitter melon, such as charantin, vicine, momordenol, momordicilin, and momordicoside, were evaluated for their ability to interact with the human UDP-Galactose 4-Epimerase receptor, a key enzyme involved in glucose metabolism. The docking results indicate that these compounds exhibit strong binding affinities, suggesting their role in glucose regulation. Further ADME analysis revealed that the compounds generally comply with the Lipinski Rule of Five, indicating favorable drug-like properties, though some compounds exhibited potential toxicities requiring further investigation. These findings highlight the potential of Momordica charantia as a source of antidiabetic agents, warranting additional in vivo and clinical studies to confirm their efficacy and safety in managing diabetes mellitus.
Co-Authors Alfiannur, Muhammad Rizky Amalia, Nadhifah Suci Chaerul Fadly Mochtar Damis, Nur Lutfiah Hamzah, Hasyrul I Wayan Surya Rahadi Indriyani, Juniar Rakhmatia Muh Irham Bakhtiar Pramesthi, Asri Dwi Endah Dewi Pratama, Aldo Putri, Nur Octaviany Rasida, Rima Suwarno, Kafka Navisa