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All Journal Jurnal Teknik Kimia USU Narra J Jurnal Teknik Kimia USU
Pratama, Muhammad A.
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Neuroprotective and inflammatory biomarkers in pediatric drug-resistant epilepsy: Interplay between GDNF, IL-1β and vitamin D 25-OH Saing, Johannes H.; Sari, Dina K.; Supriatmo, Supriatmo; Fithrie, Aida; Rusda, Muhammad; Amin, Mustafa M.; Pratama, Muhammad A.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1581

Abstract

Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegeneration. Vitamin D 25-OH exerts neuroprotective effects, while glial cell line-derived neurotrophic factor (GDNF) and the proinflammatory cytokine interleukin-1β (IL-1β) are implicated in the mechanisms of neuroinflammation and epileptogenesis. The aim of this study was to investigate the relationship between vitamin D 25-OH, IL-1β, and GDNF levels with seizure severity and frequency in children with drug-resistant epilepsy. A cross-sectional study was conducted at Adam Malik Hospital, Medan, Indonesia, among children with drug-resistant epilepsy. Vitamin D 25-OH, IL-1β and GDNF levels were measured using enzyme-linked immunosorbent assay (ELISA). Epilepsy severity was assessed using the Hague Seizure Severity Scale (HASS), while seizure frequency was assessed using the Global Assessment of Severity of Epilepsy (GASE). The present study identified a significant correlation between GDNF levels and epilepsy severity, as measured by the HASS score (r=0.318; p=0.006). However, no significant correlation was observed between vitamin D 25-OH or IL-1β levels and epilepsy severity or seizure frequency (p>0.05). IL-1β levels correlated significantly with GDNF levels (r=0.525; p=0.001), but IL-1β did not directly correlate with seizure frequency or epilepsy severity. In conclusion, GDNF levels significantly correlated with epilepsy severity, suggesting that GDNF may serve as a potential biomarker for assessing epilepsy severity. However, further studies investigating the role of GDNF as a potential neurotrophic factor in the pathophysiology of epilepsy and its possible application as a therapeutic target are important.
Penyediaan Biofilm Berbasis Pektin Kulit Buah Cempedak (Artocarpus champaden L.) Terisi Carboxymethyl Cellulose dengan Variasi Konsentrasi Gliserol Untuk Menurunkan Susut Bobot Buah Mangga Batu Bara, Fachreza Amri; Pratama, Muhammad A.; Ginting, Muhammad Hendra S.; Harahap, Hamidah; Dalimunthe, Nisaul Fadilah; Al Fath, Muhammad Thoriq
Jurnal Teknik Kimia USU Vol. 14 No. 1 (2025): Jurnal Teknik Kimia USU
Publisher : Talenta Publisher (Universitas Sumatera Utara)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jtk.v14i1.18721

Abstract

Cempedak peel contains 38.85% pectin compounds and has the potential to become biofilm raw material. The characteristics of pectin-based biofilm can be improved by the addition of a glycerol plasticizer. This study aims to determine the effect of variations in glycerol concentration (0%; 3%; 5%; 7% and 9%) on biofilm charactersitics and biofilm application on the shelf life of mango fruit. Pectin was extracted using 5% citric acid at 85°C or 90 minutes. Biofilms were applied on mango fruit for 8 days. Analysis of pectin compounds showed a yield 22.09%; ash content 7.40%; equivalent weight 588.235 mg; methoxyl content 6.20%; galacturonic acid content 36.12%. Analysis of physical properties and biofilm application on mango fruit showed a density value of 2.833 g/mL; water solubility 79.41%; mango weight loss of 33.47%; and a deacrease in vitamin C of 5%. SEM-EDX analysis showed the pectin particles were homogeneous fine grains and dominated by the element of oxygen (O) 88.84%. FTIR analysis of cempedak fruit peel pectin and biofilm showed functional groups of O-H; C-H (methyl); C=O; C-O; C-C.
Penyediaan Biofilm Berbasis Pektin Kulit Buah Cempedak (Artocarpus champaden L.) Terisi Carboxymethyl Cellulose dengan Variasi Konsentrasi Gliserol Untuk Menurunkan Susut Bobot Buah Mangga Batu Bara, Fachreza Amri; Pratama, Muhammad A.; Ginting, Muhammad Hendra S.; Harahap, Hamidah; Dalimunthe, Nisaul Fadilah; Al Fath, Muhammad Thoriq
Jurnal Teknik Kimia USU Vol. 14 No. 1 (2025): Jurnal Teknik Kimia USU
Publisher : Talenta Publisher (Universitas Sumatera Utara)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jtk.v14i1.18721

Abstract

Cempedak peel contains 38.85% pectin compounds and has the potential to become biofilm raw material. The characteristics of pectin-based biofilm can be improved by the addition of a glycerol plasticizer. This study aims to determine the effect of variations in glycerol concentration (0%; 3%; 5%; 7% and 9%) on biofilm charactersitics and biofilm application on the shelf life of mango fruit. Pectin was extracted using 5% citric acid at 85°C or 90 minutes. Biofilms were applied on mango fruit for 8 days. Analysis of pectin compounds showed a yield 22.09%; ash content 7.40%; equivalent weight 588.235 mg; methoxyl content 6.20%; galacturonic acid content 36.12%. Analysis of physical properties and biofilm application on mango fruit showed a density value of 2.833 g/mL; water solubility 79.41%; mango weight loss of 33.47%; and a deacrease in vitamin C of 5%. SEM-EDX analysis showed the pectin particles were homogeneous fine grains and dominated by the element of oxygen (O) 88.84%. FTIR analysis of cempedak fruit peel pectin and biofilm showed functional groups of O-H; C-H (methyl); C=O; C-O; C-C.
Co-Authors Al Fath, Muhammad Thoriq Amin, Mustafa M. Batu Bara, Fachreza Amri Dalimunthe, Nisaul Fadilah Fithrie, Aida Hamidah Harahap, Hamidah Ida Ayu Putu Sri Widnyani Johannes H. Saing, Johannes H. Muhammad Hendra S Ginting Rusda, Muhammad Sari, Dina K. Supriatmo Supriatmo, Supriatmo