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All Journal Narra J Jurnal Penyakit Dalam Indonesia
Supriatmo Supriatmo, Supriatmo
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Korelasi Skor Get with The Guidelines-Heart Failure dan Rasio Platelet Limfosit pada Pasien Rawat Inap dengan Gagal Jantung Panjaitan, Samuel Hendryk; Dalimunthe, Naomi Niari; Supriatmo, Supriatmo; Pradana, Andika
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Abstract

Introduction. The Get with the Guidelines-Heart Failure (GWTG-HF) risk score is a widely utilized and validated tool for assessing prognosis in patients with heart failure. Inflammation significantly contributes to the pathophysiology of heart failure, evidenced by platelet activation and a reduction in lymphocyte counts. Consequently, the platelet-to-lymphocyte ratio (PLR) may function as a prognostic biomarker in this population. This study aims to investigate the correlation between the GWTG-HF risk score and PLR as an inflammatory marker in patients hospitalized with heart failure. Methods. This cross-sectional study utilized medical records of heart failure patients admitted to Adam Malik Hospital in Medan from January 2022 to July 2023. Total GWTG-HF scores and PLR values were recorded at the time of patient admission. Correlation analyses were conducted to assess the relationship between the two variables. Results. The study evaluated 106 patient records, with male patients comprising 72.64% and a mean age of 55.84 (SD 14.09) years. The median GWTG-HF score was 37.5, while the median PLR was 137.14. Correlation analysis yielded a coefficient of r = 0.249 (p < 0.05), indicating a statistically significant association.Conclusion. A weak positive correlation exists between the GWTG-HF score and PLR in patients with heart failure, suggesting that PLR may serve as a supplementary inflammatory marker in prognostic assessments.
Comparison of total and partial parenteral nutrition to achieve calorie target among treated children in the intensive care unit Widyastuti, Syafrida; Trisnawati, Yunnie; Supriatmo, Supriatmo
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.766

Abstract

The achievement of recommended calorie targets for parenteral nutrition in pediatric patients receiving treatment in the pediatric intensive care unit (PICU) in Indonesia remains suboptimal, necessitating cautious implementation of this nutritional intervention alone. The aim of this study was to compare the effectiveness of total parenteral nutrition (TPN) and partial parenteral nutrition (PPN) in achieving the calorie requirements of pediatric patients receiving treatments in the PICU. A cross-sectional study was conducted in the PICU at H. Adam Malik General Hospital, Medan, Indonesia, among patients aged between 28 days to 18 years. The consecutive sampling method was employed to collect samples based on predetermined inclusion and exclusion criteria. The assessments of recommended calorie achievement targets were conducted up to 240 hours after initial nutrition treatment. Other possible factors associated with the achievement of the nutrition target were also assessed between groups, such as demographic data, length of treatment, nutritional status, and underlying diseases. A total of 30 patients were included in each group (TPN and PPN). There were no significant differences in age, weight, height, sex, or underlying diseases between groups. All patients in both groups achieved the target calorie requirements after 168 hours. Our data indicated that the percentage of patients who met the target calorie requirements was significantly different at initial treatment, 72 hours, and 120 hours post-treatment between groups (all had p<0.001). The percentages of patients who met the nutritional requirements (carbohydrate and protein) were also significantly different between the TPN and PPN groups (all had p<0.001). This study highlights that the administration of PPN to children resulted in faster achievement of calorie targets compared to TPN.
Neuroprotective and inflammatory biomarkers in pediatric drug-resistant epilepsy: Interplay between GDNF, IL-1β and vitamin D 25-OH Saing, Johannes H.; Sari, Dina K.; Supriatmo, Supriatmo; Fithrie, Aida; Rusda, Muhammad; Amin, Mustafa M.; Pratama, Muhammad A.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1581

Abstract

Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegeneration. Vitamin D 25-OH exerts neuroprotective effects, while glial cell line-derived neurotrophic factor (GDNF) and the proinflammatory cytokine interleukin-1β (IL-1β) are implicated in the mechanisms of neuroinflammation and epileptogenesis. The aim of this study was to investigate the relationship between vitamin D 25-OH, IL-1β, and GDNF levels with seizure severity and frequency in children with drug-resistant epilepsy. A cross-sectional study was conducted at Adam Malik Hospital, Medan, Indonesia, among children with drug-resistant epilepsy. Vitamin D 25-OH, IL-1β and GDNF levels were measured using enzyme-linked immunosorbent assay (ELISA). Epilepsy severity was assessed using the Hague Seizure Severity Scale (HASS), while seizure frequency was assessed using the Global Assessment of Severity of Epilepsy (GASE). The present study identified a significant correlation between GDNF levels and epilepsy severity, as measured by the HASS score (r=0.318; p=0.006). However, no significant correlation was observed between vitamin D 25-OH or IL-1β levels and epilepsy severity or seizure frequency (p>0.05). IL-1β levels correlated significantly with GDNF levels (r=0.525; p=0.001), but IL-1β did not directly correlate with seizure frequency or epilepsy severity. In conclusion, GDNF levels significantly correlated with epilepsy severity, suggesting that GDNF may serve as a potential biomarker for assessing epilepsy severity. However, further studies investigating the role of GDNF as a potential neurotrophic factor in the pathophysiology of epilepsy and its possible application as a therapeutic target are important.
Co-Authors Amin, Mustafa M. Andika Pradana Dalimunthe, Naomi Niari Fithrie, Aida Johannes H. Saing, Johannes H. Panjaitan, Samuel Hendryk Pratama, Muhammad A. Rusda, Muhammad Sari, Dina K. Widyastuti, Syafrida Yunnie Trisnawati, Yunnie