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All Journal Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia
Setiyawan, Sukamto Jodi
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Chemistry Medicine & Pharmacology

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REVIEW: ANALYTICAL NARRATIVE IN-DEPTH UNDERSTANDING OF FORMULATION METHODS AND TRANSFERSOME CHARACTERIZATION FOR THERAPEUTIC APPLICATIONS Setiyawan, Sukamto Jodi; Astuti, Ika Yuni; Hariyanti , Hariyanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1293

Abstract

Transdermal drug delivery systems offer a non-invasive method for drug penetration through the skin but face significant challenges, especially in the stratum corneum layer, which inhibits drug penetration. Transfersome, an elastic vesicle developed from one of the nanocarriers, liposomes, has proven effective in increasing transdermal drug penetration. To examine manufacturing methods, evaluate potential safety aspects, and apply transfersomes to increase transdermal penetration of active ingredients. The results of the article search showed that transfersomes have advantages in terms of adsorption efficiency, elasticity, and the ability to carry drugs with various vesicle sizes. Several transfersome manufacturing methods have been developed, such as thin-film hydration, reverse evaporation, high-level homogenization, sonication, and ethanol injection, each with advantages and disadvantages. The thin-film hydration method is often used in research because it results in high adsorption efficiency, superior penetration ability, and good compatibility. Transfersomes have proven to be effective elastic vesicle delivery systems with phospholipids and surfactants. In transdermal applications, transfersome successfully improve the penetration and therapeutic effectiveness of antioxidant, anticancer, corticosteroid, and anti-inflammatory drugs, in the context of increasing drug penetration and therapeutic effectiveness. Transfersomes are promising drug delivery systems for transdermal applications, offering increased penetration, bioavailability, and therapeutic effectiveness. Appropriate formulation methods and in-depth characterization are needed to optimize the therapeutic potential of transfersomes for various medical applications. Keywords: Transfersomes, transdermal delivery, lipid vesicles, entrapment efficiency, vesicle deformability, transfersome manufacturing method.
Optimization of Phosphatidylcholine and Tween 80 Composition in the Formulation of Icariin Transfersome as a Transdermal Delivery System using Design-Expert Setiyawan, Sukamto Jodi; Astuti, Ika Yuni; Hariyanti, Hariyanti
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Icariin is the main flavonoid of Epimedium sp. and has phosphodiesterase type-5 inhibitor (PDE5I) activity; however, its low water solubility and membrane permeability limit its oral bioavailability. The transferosome-based transdermal drug delivery system approach is considered promising because it can increase skin penetration and avoid the first-pass metabolism. This study aims to optimize the composition of phosphatidylcholine and Tween 80 in icariin-loaded transfersome vesicles to produce optimal physicochemical characteristics for transdermal applications. Method: Icariin transfersome was formulated using a thin-film hydration method with variations in phosphatidylcholine and Tween 80 concentrations. Optimization is performed using the Simplex Lattice Design (SLD) in Design Expert 13 software. The observed responses included particle size, polydispersity index (PDI), zeta potential, and Entrapment efficiency (EE%). The results of this study are the optimal formula of icariin transfersome, with a ratio of phosphatidylcholine and Tween 80 of 95%: 5%, resulting in ideal vesicle characteristics, namely a particle size of 106.15 nm, a zeta potential of -22.67 mV, a Polydispersity Index (PDI) of 0.37, and an Entrapment efficiency of 86.96%.
Co-Authors Hariyanti , Hariyanti Hariyanti Hariyanti Ika Yuni Astuti