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All Journal BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Nur Atika Astriani
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Religion Agriculture, Biological Sciences & Forestry Humanities Dentistry Education Environmental Science Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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PENELUSURAN AKTIVITAS ANTIBIOFILM DAN FORMULASI SPONS Petrosia sp. SEBAGAI NANOGEL PENYEMBUH LUKA ULKUS DIABETIKUM AKIBAT INFEKSI BIOFILM Staphylococcus aureus Arifin Nur Fahdianto; Virgiawan Yoga Pratama; Hasyrul Hamzah; Indra Yudhawan; Nur Atika Astriani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1804

Abstract

Diabetic ulcers are known to be one of the most feared complications and account for 80% of hospital admissions in patients with Diabetes Mellitus (DM). Diabetic ulcers occur due to bacterial infections, exacerbated by the formation of biofilm in the wounds. Nanotechnology presents a new alternative strategy for inhibiting biofilm formation, one of which is nanogel. The richness of marine biota that has the potential as an anti-biofilm candidate includes Petrosia sp. This study aims to extract and test the anti-biofilm activity of the Petrosia sp. formulation as a nanogel for healing diabetic ulcers caused by biofilm infection of Staphylococcus aureus. The extraction method used is maceration with 96% ethanol as a solvent, and biofilm activity is determined using the microtiter broth method. The procedure for creating incisional wounds on male mice induced with diabetes by alloxan is performed after shaving the fur in the area to be incised, followed by the application of 2% lidocaine cream as a local anesthetic. Subsequently, a preclinical trial on male mice is conducted by monitoring the stages of S. aureus biofilm wounds in both the test group and the positive control group. The results show that the nanogel formula from Petrosia sp. can inhibit up to 78.04% ± 0.01 on diabetic ulcer wounds with S. aureus biofilm over a period of 10 days and is highly potential to be developed as a new anti-biofilm candidate for diabetic ulcers caused by S. aureus biofilm.
PEMBUATAN TEH BUNGA TELANG (Clitoria ternatea L.) DAN AKAR KAYU BAJAKAH (Spatholobus littoralis H.) SEBAGAI ANTIDIABETES DI KAMPUNG KETUPAT KECAMATAN SAMARINDA Hamzah, Hasyrul; Mentarry Bafadal; Rahman Anshari; Nur Atika Astriani; Syayid Al Manar; Ahmad Faqih; Lila Zulfa Kamila; Norma Feti Farida; Jamiatur Rasyidah; Nur Halimah
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 2 (2025)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v6i2.11629

Abstract

Bunga telang (Clitoria ternatea L.) dan akar kayu bajakah (Spatholobus littoralis H.) memiliki kandungan senyawa kimia seperti tanin, flavonoid, dan saponin, yang berpotensi memberikan efek farmakologi, termasuk sebagai antidiabetes dan antioksidan. Namun, pemanfaatan kedua tanaman ini di masyarakat, khususnya di Kampung Ketupat, masih minim. Oleh karena itu, dilakukan kegiatan pengabdian masyarakat yang bertujuan untuk meningkatkan pengetahuan dan keterampilan ibu-ibu PKK di desa Kampung Ketupat mengenai pembuatan teh herbal dari kombinasi bunga telang dan akar kayu bajakah. Kegiatan ini meliputi penyuluhan dan pelatihan yang diakhiri dengan kuesioner untuk mengukur peningkatan pengetahuan peserta. Hasilnya menunjukkan peningkatan pemahaman masyarakat hingga 100%
Co-Authors Ahmad Faqih Anshari, Rahman Arifin Nur Fahdianto Bafadal, Mentarry Hamzah, Hasyrul Indra Yudhawan Jamiatur Rasyidah Lila Zulfa Kamila Norma Feti Farida Nur Halimah Syayid Al Manar Virgiawan Yoga Pratama