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All Journal Jurnal Ilmu Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Indra Yudhawan
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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PENELUSURAN AKTIVITAS ANTIBIOFILM DAN FORMULASI SPONS Petrosia sp. SEBAGAI NANOGEL PENYEMBUH LUKA ULKUS DIABETIKUM AKIBAT INFEKSI BIOFILM Staphylococcus aureus Arifin Nur Fahdianto; Virgiawan Yoga Pratama; Hasyrul Hamzah; Indra Yudhawan; Nur Atika Astriani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1804

Abstract

Diabetic ulcers are known to be one of the most feared complications and account for 80% of hospital admissions in patients with Diabetes Mellitus (DM). Diabetic ulcers occur due to bacterial infections, exacerbated by the formation of biofilm in the wounds. Nanotechnology presents a new alternative strategy for inhibiting biofilm formation, one of which is nanogel. The richness of marine biota that has the potential as an anti-biofilm candidate includes Petrosia sp. This study aims to extract and test the anti-biofilm activity of the Petrosia sp. formulation as a nanogel for healing diabetic ulcers caused by biofilm infection of Staphylococcus aureus. The extraction method used is maceration with 96% ethanol as a solvent, and biofilm activity is determined using the microtiter broth method. The procedure for creating incisional wounds on male mice induced with diabetes by alloxan is performed after shaving the fur in the area to be incised, followed by the application of 2% lidocaine cream as a local anesthetic. Subsequently, a preclinical trial on male mice is conducted by monitoring the stages of S. aureus biofilm wounds in both the test group and the positive control group. The results show that the nanogel formula from Petrosia sp. can inhibit up to 78.04% ± 0.01 on diabetic ulcer wounds with S. aureus biofilm over a period of 10 days and is highly potential to be developed as a new anti-biofilm candidate for diabetic ulcers caused by S. aureus biofilm.
Phytochemical Screening and Thin Layer Chromatography Analysis of Ethanol Extract of Bangle Rhizome (Zingiberis cassumunar Roxb.) Ananda Choirinisa Eka Putri; Perdana Priya Haresmita; Indra Yudhawan; Diyah Tri Utami; Alfian Syarifuddin
Jurnal Ilmu Kesehatan Vol 13 No 1 (2025): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

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Bangle rhizome (Zingiber cassumunar Roxb.) is a part of the plant that is widely used in traditional medicine because its diverse secondary metabolites have great potential in treating various diseases. The aim of this research is to identify the content of curcumin and active compounds found in bangle rhizome (Zingiber cassumunar Roxb.) qualitatively and quantitatively using Thin Layer Chromatography and UV-Vis Spectrophotometry methods. The maceration method was used to extract the bangle rhizome with 70% ethanol solvent, resulting in an extract yield of 7.92%. The results of the study from qualitative analysis using Thin Layer Chromatography (TLC) with 3 different mobile phases, namely chloroform: ethanol (95:5), chloroform: methanol: glacial acetic acid (94:5:1), and chloroform: n-hexane: methanol (1:1:0.1), indicate that the ethanol extract from the bangle rhizome positively contains polyphenolic compounds, terpenoids, and glycosides. Quantitative analysis of curcumin using UV-Vis Spectrophotometry at a wavelength of 437 nm resulted in a linear equation y = 0.026x + 0.1026 with an R² value of 0.9958 and r = 0.997898. The absorbance values from the 3 replicates of the bangle rhizome ethanol extract sample solution obtained in this study were 0.35 nm; 0.38 nm; 0.392 nm, indicating the presence of curcumin in all three replicates of the bangle rhizome ethanol extract solution. Based on the research results, it can be concluded that the ethanol extract of bangle rhizome (Zingiber cassumunar Roxb.) positively contains polyphenolic compounds, terpenoids, glycosides, and curcumin.
Co-Authors Alfian Syarifuddin Ananda Choirinisa Eka Putri Arifin Nur Fahdianto Diyah Tri Utami Hamzah, Hasyrul Nur Atika Astriani Perdana Priya Haresmita Virgiawan Yoga Pratama