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All Journal agriTECH Jurnal Mandala Pharmacon Indonesia
Umar, Abd. Halim
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Agriculture, Biological Sciences & Forestry Medicine & Pharmacology

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Fingerprint Metabolite of Miana (Coleus sp.) Leaf Infusion and Juice: Authentication Based on FTIR Spectroscopy and Multivariate Analysis Syahruni, Reny; Umar, Abd. Halim; Matasik, Lois Christfani
agriTECH Vol 44, No 4 (2024)
Publisher : Faculty of Agricultural Technology, Universitas Gadjah Mada, Yogyakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/agritech.88706

Abstract

Miana (Coleus sp.) is a plant belonging to the Lamiaceae family and has been widely used in traditional medicine. Despite the potential of the plant, the quality and quantity of chemical components that can be extracted are dependent on various factors, such as varieties and extraction techniques. Therefore, this study aimed to discriminate miana based on varieties and extraction techniques as well as identify its marker functional groups. The 4 different leaf varieties of the plant, including purple, green, batik, and color combination were extracted using the infusion method, both with and without the addition of water. FTIR (Fourier transform infrared) fingerprint metabolite of each extract was then analyzed with IRPal 2.0 software for functional group interpretation and multivariate data analysis (PCA and PLS-DA) using MetaboAnalyst 5.0. The results showed that the chromatogram profile of all varieties and extraction techniques had similar patterns. The PCA (principal component analysis) score plot yielded a total PC value of 98.5%, which could effectively discriminate the samples. In addition, the O–H group’s VIP score value (greater than 1) was a significant functional group that characterized the samples. Based on these results, the combination of FTIR spectroscopy and multivariate analysis could be used to discriminate miana based on varieties and extraction techniques, as well as identify functional groups serving as marker.
Penentuan Profil Metabolit dan Uji Aktivitas Antioksidan Pada Fraksi Daun Sawo Duren (Chrysophyllum Cainito L.) Agiel, Fadillah Maryam Bau; Umar, Abd. Halim; Ulfa, Maria; Mus, Suwahyuni; Imrawati, Imrawati
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.702

Abstract

Sawo duren (Chrysophyllum cainito L.) merupakan tanaman yang banyak digunakan dalam pengobatan, diantaranya antiinflamasi, antidiabetes dan sebagai antioksidan. Daun sawo duren mengandung senyawa saponin, triterpenoid, flavonoid, fenolik, serta alkaloid dan steroid. Tujuan dari penelitian ini adalah untuk mengalisis dan membandingkan profil metabolit fraksi n-Butanol daun sawo duren berdasarkan analisis FTIR. Proses ekstraksi daun sawo duren dilakukan dengan metode maserasi menggunakan pelarut etanol kemudian difraksinasi menggunakan pelarut etanol, n-heksan dan n-butanol. tahapan selanjutnya fraksi n-butanol dipilih untuk analisis FTIR. Hasil dari analisis spektrum untuk sampel fraksi daun sawo duren memiliki O-H (Fenol), C-H (Alkana), C-O (Alkohol), C=O (Aldehida), C=C (Alkena) terdeteksi pada sampel. Berdasarkan hasil data FTIR menunjukkan adanya gugus fungsi O-H yang diprediksi merupakan senyawa fenol, saponin dan tanin; C-H alkana diprediksi senyawa terpenoid dan steroid; C-H aromatic diprediksi senyawa fenol; dan C-O diprediksi senyawa flavonoid, alkaloid dan tanin.
Co-Authors Agiel, Fadillah Maryam Bau Maria Ulfa Mar’atun Jannah, Imrawati, Muzakkir Baitz, Matasik, Lois Christfani Mus, Suwahyuni Reny Syahruni