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All Journal Jurnal Surya Masyarakat Pharmacy Reports
Amalia, Miranti
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Other

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Penyuluhan dan Pemberian Obat Cacing Tingkat TK di RA Muslimat NU Tarbiyatul Athfal Setyoningsih, Heni; Amalia, Miranti; Safuroh, Siti; Yudanti, Gendis Purno; Susiloningrum, Dwi; Wijaya, Hasty Martha; Palupi, Dian Arsanti
Jurnal Surya Masyarakat Vol 7, No 1 (2024): November 2024
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.7.1.2024.128-132

Abstract

Worms are still a health problem in Indonesian with a general prevalence that is still very high, varying between 2.5% - 62%. These worms can result in decreased health, nutrition, intelligence and productivity. Worms cause loss of carbohydrates and protein as well as blood loss, thereby reducing the quality of human resources. One way to control worms is by giving mass medication to prevent worms in vulnerable groups to stop the spread of worm eggs from suffers to the surrounding environment, in which case the drug albendazole is given. The method used to overcome this problem is by providing counselling and administering the drug albendazole at the RA Muslimat NU Tarbiyatul Athfal Kindergarten level. A total of 125 children received counselling and distribution of the drug albendazole. The result and conclusions obtained by administering worm medicine were appropriate because all children each received 1 tablet of albendazole.
Molecular docking analysis of guaiacin and chalcone from nutmeg (Myristica fragrans) as novel HSP90A inhibitors for skin cancer treatment Arrafi, Muhammad Zhafran; Cahyani, Ayu Sukma; Sitohang, Nada Nikita; Ulya, Salsa Nabila Ahlika; Anggraeni, Inggrid; Amalia, Miranti; Putri, Gladys Ellnora; Rajwa, Raihan M Dhiya; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 3 No. 3 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.73

Abstract

Skin cancer represents one of the most prevalent malignancies globally, with Indonesia reporting the third highest incidence among cancer types. Despite advances in treatment, there remains a critical need for novel therapeutic agents. Heat Shock Protein 90 Alpha (HSP90A) has emerged as a promising target for cancer therapy due to its critical role in stabilizing oncogenic proteins. This study aimed to evaluate the potential of guaiacin and chalcone from nutmeg (Myristica fragrans) as HSP90A inhibitors for skin cancer treatment through computational analysis. Molecular docking was performed using AutoDock Tools with the HSP90A crystal structure (PDB ID: 2VCJ). The compounds were assessed for binding affinity, molecular interactions, and drug-likeness properties according to Lipinski's Rule of Five. Redocking validation yielded an RMSD of 1.24 Å, confirming protocol reliability. Guaiacin demonstrated promising binding affinity (-7.40 kcal/mol) with key hydrogen bonds to Asp93 and Lys58, while chalcone showed moderate affinity (-5.99 kcal/mol) with a single hydrogen bond to Thr184. Both compounds exhibited favorable drug-like properties with high predicted gastrointestinal absorption. Guaiacin emerges as a promising natural HSP90A inhibitor candidate with binding energy exceeding the stability threshold (-7.00 kcal/mol) and interactions with critical residues in the ATP-binding pocket, providing a foundation for further development of nutmeg-derived compounds as potential anticancer agents.
Co-Authors Anggraeni, Inggrid Anjar Hermadi Saputro Arrafi, Muhammad Zhafran Cahyani, Ayu Sukma Dian Arsanti Palupi, Dian Arsanti Hasty Martha Wijaya Putri, Gladys Ellnora Rajwa, Raihan M Dhiya Safuroh, Siti Setyoningsih, Heni Sitohang, Nada Nikita Susiloningrum, Dwi Ulya, Salsa Nabila Ahlika Winni Nur Auli Yudanti, Gendis Purno