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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Rafflesia Journal of Natural and Applied Sciences (RJNAS)
Prima Yudha, Sal
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Telaah Pustaka Penggunaan Zat Aditif Sintetik dan Ekstrak Tumbuhan pada Pelapisan Tembaga secara Listrik elwarni, Fayza maya; Alvin Reagen, Muhamad; Wiradimafan, Khafit; Prima Yudha, Sal
RAFFLESIA JOURNAL OF NATURAL AND APPLIED SCIENCES Vol. 4 No. 2 (2024): Oktober
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/rjna.v4i2.39404

Abstract

Elektroplating tembaga adalah proses pelapisan logam dengan tembaga menggunakan arus listrik. Untuk mendapatkan lapisan tembaga berkualitas optimal dengan penambahan zat aditif baik sintetik maupun alami, sangat penting untuk mengontrol pertumbuhan kristal dan distribusi ion tembaga, sehingga menghasilkan lapisan tembaga dengan kilau yang tinggi, daya lekat yang kuat, dan ketahanan korosi yang baik. Penambahan PEG, DPS, SPS, IBDGE, PBDGE, Polyquaternium-2, HEDP dan berbagai ekstrak tumbuhan (kulit bakau, daun jambu biji, daun binahong, kulit buah kakao) serta gelatin dapat secara signifikan mempengaruhi morfologi, ketebalan, dan sifat khusus pada lapisan tembaga. Mekanisme kerja aditif melibatkan interaksi kompleks antara aditif, ionlogam, dan permukaan substrat.
Gastroprotective Effect of Chitosan- Based Formulation with Chromolaena odorata L. and Peperomia pellucida L. Extracts in Ethanol-Induced Gastric Injury in Rats Pertiwi, Reza; Prima Yudha, Sal; Notriawan, Doni; Giri Samudra, Agung; Hanuun, Aanisah; Prameswari, Florencaya Prameswari; Bekti Widiansyah, Alif; Saputra, Hendri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.29054

Abstract

Gastroprotection refers to the effect of compounds that protect the gastric mucosa. Peperomia pellucida L. and Chromolaena odorata L. have demonstrated gastroprotective activities. Chromolaena odorata L., in particular, shows inhibition of gastric mucosal damage due to the presence of secondary metabolites such as flavonoids, phenolics, and tannins. Chitosan is a drug carrier that enhances drug bioavailability and allows pharmacological effects to be achieved at lower doses. This study aims to evaluate the gastroprotective activity of chitosan-based formulations containing Peperomia pellucida L. and Chromolaena odorata L. leaf extracts in rats. The contribution of this research lies in demonstrating the synergistic potential of medicinal plant extracts with chitosan as a delivery system, thereby providing a safer, more effective, and innovative therapeutic strategy for gastric ulcer management. Chitosan formulations containing Peperomia pellucida L. and Chromolaena odorata L. extracts were prepared and tested on male rats. The rats were divided into seven groups: Group I (normal control), Group II (negative control), Group III (positive control, treated with sucralfate), Groups IV and V (treated with chitosan-Chromolaena odorata formulations at doses of 100 and 200 mg/kg BW), and Groups VI and VII (treated with chitosan-Peperomia pellucida formulations at doses of 100 and 200 mg/kg BW). Treatments were administered orally for 14 days. On day 14, one hour after the final treatment, all groups except the normal group received oral absolute ethanol at a dose of 5 mL/kg BW to induce gastric injury. Gastric ulcer index, protection ratio, and histopathological changes were evaluated. The ulcer index values for the negative control, positive control, and treatment groups with doses of 100, 200, and 400 mg/kg BW were 4.89, 0.89, 0.33, 0.11, 1.00, and 0.78, respectively. The chitosan-based formulations containing Chromolaena odorata L. and Peperomia pellucida L. extracts demonstrated significant gastroprotective effects in ethanol-induced gastric injury in rats.
Co-Authors Agung Giri Samudra Alvin Reagen, Muhamad Bekti Widiansyah, Alif elwarni, Fayza maya Hanuun, Aanisah Hendri Saputra Khafit Wiradimafan Notriawan, Doni Prameswari, Florencaya Prameswari Reza Pertiwi