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All Journal Pharmaciana: Jurnal Kefarmasian JSFK (Jurnal Sains Farmasi & Klinis)
Okta Nama Putra
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pharmacological Profile and Therapeutic Potential of Sungkai Plant (Peronema canescens Jack.): An Emerging Indonesian Herbal Medicine Kokom, Asep; Yasmiwar Susilawati; Sri Adi Sumiwi; Okta Nama Putra
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.95-102.2024

Abstract

This study aimed to summarize the pharmacological activities of the sungkai plant (Peronema canescens Jack.) as a potential Indonesian herbal medicine. A literature review was conducted using Google Scholar and Scopus, with keywords such as "pharmacology," "activity," "sungkai," and "Peronema canescens." Inclusion criteria were articles with these keywords, published between 2014 and 2024, in English or Indonesian. Exclusion criteria were review articles, articles not related to sungkai plants, and in vitro and in vivo studies not available in full text. The study identified seven pharmacological activities of the sungkai plant: antioxidant, antibacterial, analgesic, antidiabetic, antihyperuricemic, anti-inflammatory, and immunomodulatory. The antioxidant activity was demonstrated using Thin Layer Chromatography (TLC) and IC50 values. The antibacterial activity was shown through bacterial growth inhibition using the Kirby-Bauer disk diffusion method. The analgesic activity was tested using the writhing test and Hot Plate methods. The antidiabetic activity was studied with alloxan induction method. Overall, the sungkai plant exhibits various pharmacological activities, suggesting its potential as an herbal medicine for treating various diseases.
Formulation of paracetamol tablets using sodium starch glycolate (SSG) derived from pineapple stem starch (Ananas comosus (L.) Merr) as a super disintegrant using wet granulation Rahayyu, Annisa Maulidia; Novi Andreyani Safitri; Riri Fauziyya; Musa Musa; Novi Kuswardani; Okta Nama Putra
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30317

Abstract

The pineapple stem, a byproduct of the pineapple plant, contains a high starch content suitable for conversion into the super disintegrant sodium starch glycolate (SSG). The starch content of pineapple stems can be modified into the super-disintegrant sodium starch glycolate (SSG). This study aims to explore the potential of modified pineapple stem starch as SSG, evaluate its physicochemical characteristics, and determine the optimal tablet. Pineapple stem starch was modified into SSG through crosslinking and carboxymethylation. Tablets were then prepared using the wet granulation method, followed by physical evaluations of tablets (weight and size uniformity, disintegration time, hardness, and friability). Four formulations with varying super disintegrant concentrations were tested: F0 (4% imported SSG, control), F1 (2% pineapple stem SSG), F2 (4% pineapple stem SSG), and F3 (6% pineapple stem SSG). The tablet evaluations for all formulations met standard requirements for each test. The study's results concluded that pineapple stem starch can be modified into SSG, exhibiting a faster swelling ability compared to natural starch. The typical functional groups of SSG appear at peaks of 1410 cm-1, 1411 cm-1, and 1415 cm-1. The best formula, F3, which is based on the physical properties of the tablets, has met the requirements with the fastest disintegration time.
Co-Authors Kokom, Asep Musa Musa Novi Andreyani Safitri Novi Kuswardani Rahayyu, Annisa Maulidia Riri Fauziyya Sri Adi Sumiwi Yasmiwar Susilawati