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Factors Influencing the Success Rates of In Vitro Fertilization (IVF) in Indonesian Couples: A Multicenter Study Sony Sanjaya; Wisnu Wardhana Putra; Theresia Putri Sinaga; Tanvir Ahmed
Sriwijaya Journal of Obstetrics and Gynecology Vol. 2 No. 1 (2024): Sriwijaya Journal of Obstetrics and Gynecology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjog.v1i2.85

Abstract

Introduction: In vitro fertilization (IVF) has become an increasingly important assisted reproductive technology for infertile couples in Indonesia. However, success rates remain variable. This multicenter study aimed to identify the factors influencing IVF success rates in Indonesian couples. Methods: A retrospective cohort study was conducted involving 1,245 couples who underwent IVF at three fertility centers in Indonesia between January 2019 and December 2022. Data were collected on demographic characteristics, infertility diagnoses, IVF protocols, and treatment outcomes. The primary outcome was live birth rate per embryo transfer. Multivariable logistic regression analysis was performed to identify independent predictors of IVF success. Results: The overall live birth rate per embryo transfer was 32.7%. Female age was a significant predictor of live birth, with success rates declining steadily after age 35. Other factors associated with higher success rates included the use of intracytoplasmic sperm injection (ICSI), blastocyst transfer, and a higher number of oocytes retrieved. Male factor infertility, endometriosis, and a history of previous failed IVF attempts were associated with lower success rates. Conclusion: This study identified several key factors influencing IVF success rates in Indonesian couples. Female age, ICSI utilization, blastocyst transfer, and oocyte yield were significant predictors of live birth. These findings can help clinicians counsel patients and optimize treatment strategies to improve IVF outcomes.
Impact of Maternal Anxiety and Stress During Pregnancy on Fetal Neurodevelopment: A Longitudinal Cohort Study in Jakarta, Indonesia Leonardo Simanjuntak; Tomiola Owkwulu; Tanvir Ahmed; Reza Andrianto; Lestini Wulansari
Scientia Psychiatrica Vol. 6 No. 1 (2025): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v6i1.182

Abstract

Introduction: Maternal anxiety and stress during pregnancy are increasingly recognized as significant factors influencing fetal neurodevelopment. This study investigated the impact of maternal anxiety and stress levels during pregnancy on various aspects of fetal neurodevelopment in a cohort of pregnant women in Jakarta, Indonesia. Methods: A longitudinal cohort study was conducted at three major hospitals in Jakarta, involving 500 pregnant women in their first trimester. Maternal anxiety and stress levels were assessed using the State-Trait Anxiety Inventory (STAI) and the Perceived Stress Scale (PSS) at three time points: first trimester (10-14 weeks), second trimester (20-24 weeks), and third trimester (30-34 weeks). Fetal neurodevelopment was assessed using fetal movement counting, fetal heart rate variability (using Doppler ultrasound), and later, infant neurodevelopmental assessments at 6 and 12 months postpartum using the Bayley Scales of Infant Development III. Data analysis involved correlation and regression analyses to examine the relationship between maternal anxiety/stress and fetal/infant neurodevelopmental outcomes. Results: The study found a significant positive correlation between maternal anxiety and stress levels across all trimesters. Higher maternal anxiety and stress, particularly in the second and third trimesters, were associated with reduced fetal movement counts (p < 0.05) and altered fetal heart rate variability patterns (p < 0.01). Furthermore, higher maternal anxiety and stress during pregnancy were associated with lower scores on the cognitive and motor scales of the Bayley Scales at both 6 and 12 months (p < 0.001). Specifically, maternal anxiety in the third trimester was the strongest predictor of lower cognitive scores at 12 months. Conclusion: Maternal anxiety and stress during pregnancy, particularly in the second and third trimesters, have a demonstrable impact on fetal neurodevelopment and subsequent infant development. These findings highlight the importance of screening for and managing maternal anxiety and stress during pregnancy to promote optimal fetal and infant neurodevelopment. Interventions targeting stress reduction and anxiety management should be integrated into routine prenatal care.
First Trimester Ultrasound Biomarkers for Predicting Preeclampsia: A Prospective Cohort Study in Surabaya, Indonesia Reisha Notonegoro; Aline Hafidzah; Reza Andrianto; Tanvir Ahmed
Sriwijaya Journal of Obstetrics and Gynecology Vol. 3 No. 1 (2025): Sriwijaya Journal of Obstetrics and Gynecology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjog.v2i2.180

Abstract

Introduction: Preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity and mortality worldwide, particularly in developing countries like Indonesia. Early identification of high-risk women is crucial for timely intervention. This study aimed to evaluate the predictive performance of first-trimester ultrasound biomarkers, specifically uterine artery pulsatility index (UtA-PI) and mean arterial pressure (MAP), combined with maternal characteristics, for predicting PE in a cohort of pregnant women in Surabaya, Indonesia. Methods: This prospective cohort study enrolled pregnant women attending their first-trimester antenatal care visit at Private Hospital, Surabaya, between January 2022 and December 2023. Inclusion criteria were singleton pregnancies, gestational age between 11 and 13 weeks 6 days, and availability of complete follow-up data until delivery. Maternal characteristics (age, body mass index, parity, smoking history, family history of PE) were recorded. UtA-PI was measured using transabdominal Doppler ultrasound, and MAP was calculated from blood pressure measurements. The primary outcome was the development of PE, defined according to the International Society for the Study of Hypertension in Pregnancy (ISSHP) criteria. Logistic regression analysis was used to develop a prediction model, and its performance was assessed using receiver operating characteristic (ROC) curves and area under the curve (AUC). Results: A total of 850 pregnant women were included in the final analysis. The incidence of PE was 8.2% (n=70). The prediction model incorporating maternal age, BMI, prior history of PE, UtA-PI, and MAP demonstrated good predictive performance for overall PE (AUC = 0.85; 95% CI, 0.81-0.89). For early-onset PE (delivery <34 weeks), the AUC was 0.92 (95% CI, 0.87-0.97), and for late-onset PE (delivery ≥34 weeks), the AUC was 0.78 (95% CI, 0.73-0.83). UtA-PI and MAP were significant independent predictors of PE (p<0.001). A risk score was developed, with a cut-off value showing a sensitivity of 80% and specificity of 75% for overall PE. Conclusion: The combination of maternal characteristics, UtA-PI, and MAP in the first trimester provides a valuable tool for predicting PE in an Indonesian population. This model demonstrates particularly strong performance for predicting early-onset PE, which is associated with greater maternal and fetal morbidity. Early identification of high-risk women allows for targeted surveillance and potential preventative strategies.
Advancing Rural Education in Bangladesh: The Strategic Role of NGOs in Expanding Access and Addressing Developmental Challenges Md. Sobuj Mia; Md. Yeasir Arafat; Md. Ismail Hossen Imran; Fahmida , Fahmida; Mst. Sumaiya Akter; Tanvir Ahmed
ENGAGEMENT: Jurnal Pengabdian Masyarakat Vol. 4 No. 4 (2025)
Publisher : Perkumpulan Dosen Fakultas Agama Islam Indramayu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58355/engagement.v4i4.180

Abstract

SDG 4 stands for giving everyone good and equal education and chances to keep learning throughout life. Non-Governmental Organizations (NGOs) play an undeniable role in tackling educational challenges in rural Bangladesh, where poverty, lack of awareness, poor infrastructure, and social barriers limit access to quality education. This study reviews the work of NGOs over recent decades to understand how they have helped improve education in rural communities. It examines how NGOs have addressed issues such as enrollment, literacy, gender equality, community involvement, and sustainability. The findings show that NGOs have increased school attendance and literacy through community-based non-formal education, scholarships, teacher training, life skills programs, and digital learning initiatives. They have also promoted gender equality and encouraged local communities to take part in education programs. Despite their success, NGOs face challenges including funding shortages, weak infrastructure, technological gaps, social resistance, and coordination difficulties with government agencies. The study offers practical suggestions for improving collaboration with the government, securing funding, enhancing teacher support, expanding digital access, and building climate resilience into education programs. Overall, the study provides clear insights for policymakers, educators, and development practitioners aiming to strengthen rural education.